Results 11 to 20 of about 88,584 (246)

Proline dehydrogenase (oxidase) in cancer. [PDF]

Biofactors, 2012
AbstractProline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the proline degradative pathway, plays a special role in tumorigenesis and tumor development. Proline metabolism catalyzed by PRODH/POX is closely linked with the tricarboxylic acid (TCA) cycle and urea cycle.
Liu W, Phang JM.
europepmc   +6 more sources

Biochemical characterization of proline dehydrogenase in Arabidopsis mitochondria [PDF]

The FEBS Journal, 2014
Proline has multiple functions in plants. Besides being a building block for protein biosynthesis proline plays a central role in the plant stress response and in further cellular processes. Here, we report an analysis on the integration of proline dehydrogenase (ProDH) into mitochondrial metabolism in Arabidopsis thaliana.
Peter, Schertl, Cécile, Cabassa, Kaouthar, Saadallah, Marianne, Bordenave, Arnould, Savouré, Hans-Peter, Braun   +5 more
openaire   +4 more sources

Sources of superoxide/H2O2 during mitochondrial proline oxidation

Redox Biology, 2014
p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand   +5 more
doaj   +3 more sources

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

Free Radical Biology and Medicine, 2012
Proline metabolism has an underlying role in apoptotic signaling that influences tumorigenesis. Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of ...
Natarajan, Sathish Kumar, Zhu, Weidong, Liang, Xinwen, Zhang, Lu, Demers, Andrew, Zimmerman, Matthew C., Simpson, Melanie A., Becker, Donald F.   +7 more
openaire   +5 more sources

Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis [PDF]

BMC Plant Biology, 2010
Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun, Eckard Sonja, Funck Dietmar   +2 more
doaj   +4 more sources

Proline dehydrogenase: a key enzyme in controlling cellular homeostasis

Frontiers in Bioscience, 2012
Proline dehydrogenase (ProDH), also called proline oxidase (POX), is a universal enzyme in living organisms. It catalyzes the oxidation of L-proline to delta1-pyrroline-5-carboxylate leading to the release of electrons, which can be transferred to either electron transfer systems or to molecular oxygen.
Caroline, Servet, Thanos, Ghelis, Luc, Richard, Aviah, Zilberstein, Arnould, Savoure   +4 more
openaire   +4 more sources

Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase. [PDF]

Org Biomol Chem, 2022
PRODH plays a central role in the metabolic rewiring of cancer cells. Analysis of 18 proline analogs using kinetics and crystallography revealed an unexpected synergism between inhibitor ring size and hydrogen bonding to an active site water molecule.
Bogner AN, Tanner JJ.
europepmc   +3 more sources

Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. [PDF]

Amino Acids, 2021
AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Palka J, Oscilowska I, Szoka L.
europepmc   +4 more sources

NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells. [PDF]

Int J Mol Sci, 2022
Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activated receptor-γ (PPARγ)-induced apoptosis independent of the COX-2 inhibition, and the process was ...
Kazberuk A, Chalecka M, Palka J, Bielawska K, Surazynski A.   +4 more
europepmc   +4 more sources

Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line. [PDF]

Int J Mol Sci, 2022
Oscilowska I, Rolkowski K, Baszanowska W, Huynh TYL, Lewoniewska S, Nizioł M, Sawicka M, Bielawska K, Szoka P, Miltyk W, Palka J.   +10 more
europepmc   +2 more sources