Proline dehydrogenase (oxidase) in cancer [PDF]
BioFactors, 2012 AbstractProline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the proline degradative pathway, plays a special role in tumorigenesis and tumor development. Proline metabolism catalyzed by PRODH/POX is closely linked with the tricarboxylic acid (TCA) cycle and urea cycle.
Liu W, Phang JM.
exaly +5 more sources
Putative mitochondrial α-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae [PDF]
Microbial Cell, 2016 The amino acid proline functions as a nitrogen source and as a stress protectant in the yeast Saccharomyces cerevisiae. However, utilization of proline as a carbon source in S. cerevisiae cells has not been studied yet.
Ikuhisa Nishida +2 more
doaj +2 more sources
Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. [PDF]
ACS Chem Biol, 2021 Proline dehydrogenase (PRODH) is a flavoenzyme that catalyzes the first step of proline catabolism, the oxidation of l-proline to Δ1-pyrroline-5-carboxylate.
Campbell AC +6 more
europepmc +4 more sources
Proline dehydrogenase is essential for proline protection against hydrogen peroxide induced cell death [PDF]
Free Radical Biology and Medicine, 2012 Proline metabolism has an underlying role in apoptotic signaling that impacts tumorigenesis. Proline is oxidized to glutamate in the mitochondria with the rate limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53
Zhu, Weidong +7 more
core +4 more sources
Proline Dehydrogenase Contributes to Pathogen Defense in Arabidopsis [PDF]
Plant Physiology, 2011 l-Proline (Pro) catabolism is activated in plants recovering from abiotic stresses associated with water deprivation. In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Ɗ1-pyrroline-5 ...
Nicolás Miguel Cecchini +2 more
core +4 more sources
Sources of superoxide/H2O2 during mitochondrial proline oxidation [PDF]
Redox Biology, 2014 p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Renata L.S. Goncalves +5 more
doaj +2 more sources
Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis [PDF]
BMC Plant Biology, 2010 Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun +2 more
doaj +4 more sources
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. [PDF]
Amino Acids, 2021 AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Palka J, Oscilowska I, Szoka L.
europepmc +4 more sources
The effect of water deficit and excess copper on proline metabolism in Nicotiana benthamiana
Biologia Plantarum, 2012 Fluctuation in proline content is a widespread phenomenon among plants in response to heavy metal stress. To distinguish between the participation of water deficit and copper on changes in proline metabolism, potted plants and floating leaf discs of ...
H. -M. Ku +5 more
doaj +2 more sources
Characterisation of proline dehydrogenase and its contribution to energy metabolism in Trypanosoma brucei [PDF]
, 2004 Both Leishmania major and Trypanosoma brucei undergo a complicated developmental cycle involving insect vectors and a mammalian host, subjecting these parasites to dramatic changes in their environment.
Lamour, Nadia
core +7 more sources