Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis [PDF]
BMC Plant Biology, 2010 Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun +2 more
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Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. [PDF]
Amino Acids, 2021 AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Palka J, Oscilowska I, Szoka L.
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Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase. [PDF]
Org Biomol Chem, 2022 PRODH plays a central role in the metabolic rewiring of cancer cells. Analysis of 18 proline analogs using kinetics and crystallography revealed an unexpected synergism between inhibitor ring size and hydrogen bonding to an active site water molecule.
Bogner AN, Tanner JJ.
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NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells. [PDF]
Int J Mol Sci, 2022 Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activated receptor-γ (PPARγ)-induced apoptosis independent of the COX-2 inhibition, and the process was ...
Kazberuk A +4 more
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Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. [PDF]
ACS Chem Biol, 2021 Proline dehydrogenase (PRODH) is a flavoenzyme that catalyzes the first step of proline catabolism, the oxidation of l-proline to Δ1-pyrroline-5-carboxylate. PRODH has emerged as a cancer therapy target because of its involvement in the metabolic reprogramming of cancer cells.
Campbell AC +6 more
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Proline Dehydrogenase Contributes to Pathogen Defense in Arabidopsis [PDF]
Plant Physiology, 2011 Abstract l-Proline (Pro) catabolism is activated in plants recovering from abiotic stresses associated with water deprivation. In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Ɗ1-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Ɗ1-pyrroline-5-carboxylate (P5C) as ...
Nicolás M. Cecchini +2 more
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Rapid Reaction Kinetics of Proline Dehydrogenase in the Multifunctional Proline Utilization A Protein [PDF]
Biochemistry, 2011 The multifunctional proline utilization A (PutA) flavoenzyme from Escherichia coli catalyzes the oxidation of proline to glutamate in two reaction steps using separate proline dehydrogenase (PRODH) and Δ(1)-pyrroline-5-carboxylate (P5C) dehydrogenase domains.
Michael A, Moxley, Donald F, Becker
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Iranian Journal of Microbiology, 2011 Background and Objectives: Proline dehydrogenase (ProDH; 1.5.99.8) plays an important role in specific determination of plasma proline level in biosensor and diagnostic kits.
H Shahbaz- Mohammadi, E Omidinia
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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate. [PDF]
ACS Chem Biol, 2020 Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Δ1-pyrroline-5-carboxylate. PRODH has emerged as a possible cancer therapy target, and thus the inhibition of PRODH is of interest.
Campbell AC +3 more
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Altered Levels of Proline Dehydrogenase Cause Hypersensitivity to Proline and Its Analogs in Arabidopsis [PDF]
Plant Physiology, 2002 Abstract Pro dehydrogenase (PDH) catalyzes the first and rate-limiting step in the Pro catabolic pathway. In Arabidopsis, this enzyme is encoded byAt-PDH. To investigate the role of Pro catabolism in plants, we generated transgenic Arabidopsis plants with altered levels of PDH by sense (PDH-S plants) and antisense (PDH-AS plants ...
Mani, Srikrishnan +3 more
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