Results 11 to 20 of about 47,460 (254)
Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. [PDF]
ACS Chem Biol, 2021 Proline dehydrogenase (PRODH) is a flavoenzyme that catalyzes the first step of proline catabolism, the oxidation of l-proline to Δ1-pyrroline-5-carboxylate. PRODH has emerged as a cancer therapy target because of its involvement in the metabolic reprogramming of cancer cells.
Campbell AC +6 more
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Proline Dehydrogenase Contributes to Pathogen Defense in Arabidopsis [PDF]
Plant Physiology, 2011 Abstract l-Proline (Pro) catabolism is activated in plants recovering from abiotic stresses associated with water deprivation. In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Ɗ1-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Ɗ1-pyrroline-5-carboxylate (P5C) as ...
Nicolás M. Cecchini +2 more
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Sources of superoxide/H2O2 during mitochondrial proline oxidation
Redox Biology, 2014 p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Renata L.S. Goncalves +5 more
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Agriculture, 2022 Proline (Pro) is not only an important osmotic adjustment substance, but it also plays an important role in regulating plant abiotic stress resistance. The maize varieties, Xinxin 2 (low temperature insensitive) and Damin 3307 (low temperature sensitive),
Shiyu Zuo, Jing Li, Wanrong Gu, Shi Wei
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Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline
Molecules, 2017 Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick +4 more
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Free Radical Biology and Medicine, 2012 Proline metabolism has an underlying role in apoptotic signaling that influences tumorigenesis. Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of ...
Natarajan, Sathish Kumar +7 more
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Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities [PDF]
Frontiers in Plant Science, 2020 Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton +4 more
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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate. [PDF]
ACS Chem Biol, 2020 Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Δ1-pyrroline-5-carboxylate. PRODH has emerged as a possible cancer therapy target, and thus the inhibition of PRODH is of interest.
Campbell AC +3 more
europepmc +5 more sources
The effect of water deficit and excess copper on proline metabolism in Nicotiana benthamiana
Biologia Plantarum, 2012 Fluctuation in proline content is a widespread phenomenon among plants in response to heavy metal stress. To distinguish between the participation of water deficit and copper on changes in proline metabolism, potted plants and floating leaf discs of ...
H. -M. Ku +5 more
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Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein [PDF]
Nature Structural Biology, 2003 The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilization genes. The human homolog of the PutA proline dehydrogenase (PRODH) domain is critical in p53-mediated apoptosis and schizophrenia.
Yong-Hwan, Lee +4 more
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