Results 31 to 40 of about 267,372 (195)

Proline metabolism.

, 2013
Abbreviations: PRO, proline; PRODH, proline oxidase (a.k.a. proline dehydrogenase); P5CR, pyrroline-5-carboxylate reductase; P5C, pyrroline-5-carboxylate; GSA, glutamic semialdehyde; P5CDH, pyrroline-5-carboxylate dehydrogenase; P5CS, pyrroline-5 ...
Brian Suárez Mantilla (435600), Maria Carolina Elias (243026), Lisvane Silva Paes (267021), Patrícia Diogo de Melo (435603), Erich B. Tahara (284264), Ariel Mariano Silber (167356), Elisabeth Mieko Furusho Pral (435602), Alicia J. Kowaltowski (284269), Flávia Menezes Zimbres (435601)   +8 more
core   +1 more source

Characterization of cis-4-hydroxy-D-proline dehydrogenase from Sinorhizobium meliloti

, 2018
The hypO gene from Sinorhizobium meliloti, located within the trans-4-hydroxy-L-proline metabolic gene cluster, was first successfully expressed in the host Pseudomonas putida.
Yasuo Watanabe, Fumiyasu Fukumori, Daichi Morimoto, Seiya Watanabe   +3 more
core   +1 more source

L-Proline Activates Mammalian Target of Rapamycin Complex 1 and Modulates Redox Environment in Porcine Trophectoderm Cells

Biomolecules, 2021
L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu, Ying Yang, Xuemeng Si, Hai Jia, Yunchang Zhang, Da Jiang, Zhaolai Dai, Zhenlong Wu   +7 more
doaj   +1 more source

Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis

BMC Plant Biology, 2010
Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun, Eckard Sonja, Funck Dietmar   +2 more
doaj   +1 more source

Proline and GABA biosynthesis pathway.

, 2018
For the figure legend refers to Fig 2. Abbreviations: GSA: glutamate-semialdehyde. P5C: L-1-Pyrroline-5-carboxylate. GABA: 4-aminobutanoate. P5CR: P5C reductase. P5CS1: glutamate-5-kinase. P5CS2: GSA dehydrogenase.
Lenny de Jaeger (5100551), Benoit M. Carreres (5100545), Vitor A. P. Martins Dos Santos (5100554), Gerrit Eggink (2084200), Rene H. Wijffels (5100548), Dirk E. Martens (3922190), Peter J. Schaap (216954), Jan Springer (91078)   +7 more
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Variability of leaf pubescence characteristics in transgenic tobacco lines with partial proline dehydrogenase gene suppression

Biologia Plantarum, 2022
Proline, an amino acid, plays an important role in plants, and it is involved in stress resistance and development. Earlier, to study the proline role in maintaining stress resistance in plants, we obtained genetically modified transgenic lines of ...
S.M. IBRAGIMOVA, M.A. GENAEV, A.V. KOCHETOV, D.A. AFONNIKOV   +3 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Involvement of the β3-α3 Loop of the Proline Dehydrogenase Domain in Allosteric Regulation of Membrane Association of Proline Utilization A

, 2016
Proline utilization A (PutA) from Escherichia coli is a membrane-associated trifunctional flavoenzyme that catalyzes the oxidation of proline to glutamate and moonlights as a transcriptional regulator.
Jie Y. Chan (1940824), John J. Tanner (1333191), Ashley M. Haile (1940830), Weidong Zhu (316428), John D. Larson (1940827), Danielle Smithen (1940821), Ranjan K. Singh (681647), Donald F. Becker (742832)   +7 more
core   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source