Results 1 to 10 of about 2,628 (173)

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence. [PDF]

Int J Mol Sci
The identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and ...
Grossi S, Berno E, Chiofalo P, Chiaravalli AM, Cinquetti R, Bruno A, Palano MT, Gallazzi M, La Rosa S, Sessa F, Acquati F, Campomenosi P.   +11 more
europepmc   +7 more sources

Context of action of proline dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis. [PDF]

BMC Plant Biol, 2014
La proline (Pro) déshydrogénase (ProDH) potentialise l'éclatement oxydatif et la mort cellulaire de la réponse hypersensible (RH) de la plante par des mécanismes non encore élucidés. ProDH convertit Pro en ∆1 pyrroline-5-carboxylate (P5C) et peut agir conjointement avec la P5C déshydrogénase (P5CDH) pour produire Glu, ou avec la P5C réductase (P5CR ...
Monteoliva MI, Rizzi YS, Cecchini NM, Hajirezaei MR, Alvarez ME.   +4 more
europepmc   +7 more sources

Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line [PDF]

International Journal of Molecular Sciences, 2022
The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells. PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation of cancer cell survival/apoptosis. The enzyme is activated by AMP kinase (AMPK). It has been found that
Ilona Oscilowska, Karol Rolkowski, Weronika Baszanowska, Thi Yen Ly Huynh, Sylwia Lewoniewska, Magdalena Nizioł, Magdalena Sawicka, Katarzyna Bielawska, Paweł Szoka, Wojciech Miltyk, Jerzy Palka   +10 more
openaire   +5 more sources

SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression [PDF]

Disease Models & Mechanisms, 2017
Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear.
Liesbeth Zwarts, Veerle Vulsteke, Edgar Buhl, James J. L. Hodge, Patrick Callaerts   +4 more
doaj   +5 more sources

Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations [PDF]

The Ukrainian Biochemical Journal, 2020
Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes.
F. H. Moghadam, Z. H. A. Mehrabani, M. Amounajaf, S. Rahmanzadeh, F. Ghasemvand, A. S. Samghabadi, A. Nejadmoghaddam, E. Omidinia   +7 more
doaj   +2 more sources

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase [PDF]

Molecules
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks, Alexandra N. Bogner, Jay C. Nix, John J. Tanner   +3 more
doaj   +2 more sources

Proline–Nitrogen Metabolic Coordination Mediates Cold Priming-Induced Freezing Tolerance in Maize [PDF]

Plants
Cold stress critically restricts maize seedling growth in Northeast China, yet the mechanism by which cold priming (CP) enhances cold tolerance through proline–nitrogen metabolic networks remains unclear.
Zhijia Gai, Lei Liu, Na Zhang, Jingqi Liu, Lijun Cai, Xu Yang, Ao Zhang, Pengfei Zhang, Junjie Ding, Yifei Zhang   +9 more
doaj   +2 more sources

Application of sucrose modulates the expressions of genes involved in proline and polyamine metabolism in maize seedlings exposed to drought [PDF]

Biologia Plantarum, 2019
Sucrose, proline, and polyamines are compatible solutes accumulating in plant tissues and increasing cellular osmolarity under environmental stresses. These compatible solutes and hydrogen peroxide can function as signaling molecules in plants. There has
C. Altuntaş, A. Sezgin, M. Demiralay, R. Terzi, A. Sağlam, A. Kadioğlu   +5 more
doaj   +3 more sources

Exogenous dopamine ameliorates chilling injury of banana fruits during cold storage [PDF]

Scientific Reports
This study investigated postharvest dopamine treatment efficiency in ameliorating chilling injury of banana fruits during storage at 7 ºC for 21 days.
Javad Nazari, Amrollah Nabigol, Mousa Rasouli, Morteza Soleimani Aghdam   +3 more
doaj   +2 more sources

Respiratory electron transfer pathways in plant mitochondria [PDF]

, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Braun, Hans-Peter, Schertl, Peter
core   +13 more sources