Combinatorial control of Arabidopsis proline dehydrogenase transcription by specific heterodimerisation of bZIP transcription factors [PDF]
EMBO Journal, 2006 Proline metabolism has been implicated in plant responses to abiotic stresses. The Arabidopsis thaliana proline dehydrogenase (ProDH) is catalysing the first step in proline degradation.
Katrin Dietrich +2 more
exaly +2 more sources
Proline metabolism reprogramming in cancer reveals the regulation of PRODH/POX as target
Biomedicine and Pharmacotherapyexaly
Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence [PDF]
International Journal of Molecular SciencesThe identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and mortality.
Maria TERESA Palano +2 more
exaly +8 more sources
Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis [PDF]
BMC Plant Biology, 2014 La proline (Pro) déshydrogénase (ProDH) potentialise l'éclatement oxydatif et la mort cellulaire de la réponse hypersensible (RH) de la plante par des mécanismes non encore élucidés. ProDH convertit Pro en ∆1 pyrroline-5-carboxylate (P5C) et peut agir conjointement avec la P5C déshydrogénase (P5CDH) pour produire Glu, ou avec la P5C réductase (P5CR ...
Maria Elena Alvarez +2 more
exaly +9 more sources
Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line [PDF]
International Journal of Molecular Sciences, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells. PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation of cancer cell survival/apoptosis. The enzyme is activated by AMP kinase (AMPK). It has been found that
Wojciech Miltyk +2 more
exaly +6 more sources
Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations [PDF]
The Ukrainian Biochemical Journal, 2020 Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes.
F. H. Moghadam +7 more
doaj +4 more sources
Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy? [PDF]
Frontiers in Oncology, 2023 Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Zhang Guangtao, Ji Guang, Hanchen Xu
exaly +5 more sources
Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase [PDF]
MoleculesThe proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks +3 more
doaj +4 more sources