Results 41 to 50 of about 204,753 (161)

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

Frontiers in Pharmacology, 2018
Propolis evokes several therapeutic properties, including anticancer activity. These activities are attributed to the action of polyphenols. Previously it has been demonstrated, that one of the most abundant polyphenolic compounds in ethanolic extracts ...
Katarzyna Celińska-Janowicz, Ilona Zaręba, Urszula Lazarek, Joanna Teul, Michał Tomczyk, Jerzy Pałka, Wojciech Miltyk   +6 more
doaj   +1 more source

Sources of superoxide/H2O2 during mitochondrial proline oxidation

Redox Biology, 2014
p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand   +5 more
doaj   +1 more source

L-Proline Activates Mammalian Target of Rapamycin Complex 1 and Modulates Redox Environment in Porcine Trophectoderm Cells

Biomolecules, 2021
L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu, Ying Yang, Xuemeng Si, Hai Jia, Yunchang Zhang, Da Jiang, Zhaolai Dai, Zhenlong Wu   +7 more
doaj   +1 more source

Exogenous Proline Alleviated Low Temperature Stress in Maize Embryos by Optimizing Seed Germination, Inner Proline Metabolism, Respiratory Metabolism and a Hormone Regulation Mechanism

Agriculture, 2022
Proline (Pro) is not only an important osmotic adjustment substance, but it also plays an important role in regulating plant abiotic stress resistance. The maize varieties, Xinxin 2 (low temperature insensitive) and Damin 3307 (low temperature sensitive),
Shiyu Zuo, Jing Li, Wanrong Gu, Shi Wei
doaj   +1 more source

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

The Effect of Salinity Concentration on Proline Dehydrogenase (ProDH) Gene Expression and Proline Accumulation in Black Rice and Red Rice

Discoveries in Agriculture and Food Sciences
The nutraceutical properties of the pigmented rice provide an opportunity to be widely cultivated. A tendency to grow rice on sub-optimal land such as saline soil is an alternative to support food security, but the adaptation under saline soil is still questionable. This study was performed to determine the stress resistance of black (var. Ketan Hitam),
Yosefine Fetik Rudiyanto, Wahyu Indra Duwi Fanata, Tri Agus Siswoyo   +2 more
openaire   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

Computational insights on the hydride and proton transfer mechanisms of L-proline dehydrogenase.

PLoS ONE, 2023
L-Proline dehydrogenase (ProDH) is a flavin-dependent oxidoreductase, which catalyzes the oxidation of L-proline to (S)-1-pyrroline-5-carboxylate. Based on the experimental studies, a stepwise proton and hydride transfer mechanism is supported. According
Ibrahim Yildiz
doaj   +1 more source

Seasonal shifts in mitochondrial and reactive oxygen species metabolism are linked to ultrastructural remodelling in honey bees (Apis mellifera)

The Journal of Physiology, Volume 604, Issue 12, Page 4745-4770, 15 June 2026.
Abstract figure legend Seasonal changes profoundly reshape honey bee mitochondrial metabolism. In winter, bees shift from complex I (CI)‐ to mitochondrial glycerol‐3‐phosphate dehydrogenase (mG3PDH)‐ and complex II (CII)‐linked respiration. Despite lower CI‐linked respiration ATP production is maintained, suggesting increased energetic efficiency in ...
Adèle Léger, Mélanie Aminot, Samuel Robichaud, Sarah Jorissen, Étienne Hébert‐Chatelain, Nicolas Pichaud   +5 more
wiley   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source