Results 41 to 50 of about 1,610 (139)

Electrochemical behavior of dye-linked L-proline dehydrogenase on glassy carbon electrodes modified by multi-walled carbon nanotubes

Beilstein Journal of Nanotechnology, 2010
A glassy carbon electrode (GC) was modified by multi-walled carbon nanotubes (MWCNTs). The modified electrode showed a pair of redox peaks that resulted from the oxygen-containing functional groups on the nanotube surface.
Haitao Zheng, Leyi Lin, Yosuke Okezaki, Ryushi Kawakami, Haruhiko Sakuraba, Toshihisa Ohshima, Keiichi Takagi, Shin-ichiro Suye   +7 more
doaj   +1 more source

SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression

Disease Models & Mechanisms, 2017
Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear.
Liesbeth Zwarts, Veerle Vulsteke, Edgar Buhl, James J. L. Hodge, Patrick Callaerts   +4 more
doaj   +1 more source

Catechol‐o‐methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression

Synapse, 2003
AbstractCatechol‐o‐methyltransferase (COMT) and proline dehydrogenase (PRODH) may both be susceptibility genes for schizophrenia. As part of the evaluation of their roles in psychosis, we used reverse transcription–polymerase chain reaction to measure COMT and PRODH mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, major ...
Tunbridge, E, Burnet, P, Sodhi, MS, Harrison, P   +3 more
openaire   +2 more sources

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

Molecules
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks, Alexandra N. Bogner, Jay C. Nix, John J. Tanner   +3 more
doaj   +1 more source

Sources of superoxide/H2O2 during mitochondrial proline oxidation

Redox Biology, 2014
p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Renata L.S. Goncalves, Daniel E. Rothschild, Casey L. Quinlan, Gary K. Scott, Christopher C. Benz, Martin D. Brand   +5 more
doaj   +1 more source

Advancing Thermotolerance in Beans: Integrating Physiology, Genomics, and Breeding for Climate Adaptation

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Rising global temperatures increasingly threaten bean production and the food security of millions of people who depend on these protein‐rich legumes. Heat stress during the reproductive stages induces pollen sterility, flower abscission, and disruptions in source–sink relationships, resulting in yield losses of 30%–40% or more when critical ...
Aastha Sharda, Shikha Chaudhary, Bhawna Kumari, Uday C. Jha, Mohar Singh, Inderjit Singh, Kamal Dev Sharma, Kadambot H. M. Siddique, P. V. Vara Prasad, Harsh Nayyar   +9 more
wiley   +1 more source

The Effect of Salinity Concentration on Proline Dehydrogenase (ProDH) Gene Expression and Proline Accumulation in Black Rice and Red Rice

Discoveries in Agriculture and Food Sciences
The nutraceutical properties of the pigmented rice provide an opportunity to be widely cultivated. A tendency to grow rice on sub-optimal land such as saline soil is an alternative to support food security, but the adaptation under saline soil is still questionable. This study was performed to determine the stress resistance of black (var. Ketan Hitam),
Yosefine Fetik Rudiyanto, Wahyu Indra Duwi Fanata, Tri Agus Siswoyo   +2 more
openaire   +1 more source

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

L-Proline Activates Mammalian Target of Rapamycin Complex 1 and Modulates Redox Environment in Porcine Trophectoderm Cells

Biomolecules, 2021
L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu, Ying Yang, Xuemeng Si, Hai Jia, Yunchang Zhang, Da Jiang, Zhaolai Dai, Zhenlong Wu   +7 more
doaj   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source