Biomolecules, 2021 It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh +6 more
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Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion. [PDF]
Cancer MedA hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Yajima S +12 more
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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate [PDF]
, 2020 Proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the FAD-dependent 2-electron oxidation of l-proline to Δ1-pyrroline-5-carboxylate. PRODH has emerged as a possible cancer therapy target, and thus the inhibition of PRODH is of
Kent S. Gates (1310250) +3 more
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Troglitazone-Induced PRODH/POX-Dependent Apoptosis Occurs in the Absence of Estradiol or ERβ in ER-Negative Breast Cancer Cells [PDF]
, 2021 The impact of estradiol on troglitazone (TGZ)-induced proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied in wild-type and PRODH/POX-silenced estrogen receptor (ER) dependent MCF-7 cells and ER-independent MDA-MB-231 cells ...
Ilona Oscilowska +6 more
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Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade
Cell Reports, 2016 Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders.
Gregg W. Crabtree +3 more
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Supplementation of 2-Ap, Zn and La Improves 2-Acetyl-1-Pyrroline Concentrations in Detached Aromatic Rice Panicles In Vitro. [PDF]
PLoS ONE, 2016 Aromatic rice is highly prized by consumers worldwide due to its special aromatic character. 2-acetyl-1-pyrroline (2-AP) is considered to be the single most important volatile compound responsible for aroma in aromatic rice.
Zhaowen Mo +9 more
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Proteomic and functional analysis of proline dehydrogenase 1 link proline catabolism to mitochondrial electron transport in Arabidopsis thaliana [PDF]
, 2016 International audienceProline accumulates in many plant species in response to environmental stresses. Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase
Guivarc'H, Anne +16 more
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Comparative Study of the Mitochondrial Proteome From Mesophyll, Vascular, and Guard Cells in Response to Carbon Starvation. [PDF]
Physiol PlantABSTRACT A leaf is an organ composed of different tissues that fulfill specific functions. We hypothesized that since cells in vascular or mesophyll tissues as well as in stoma are developmentally tuned to operate their functions, mitochondria from these cells could exhibit significant metabolic differences.
Boussardon C, Hussain S, Keech O.
europepmc +2 more sources
Biomolecules, 2021 L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu +7 more
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, 2013 Abbreviations: PRO, proline; PRODH, proline oxidase (a.k.a. proline dehydrogenase); P5CR, pyrroline-5-carboxylate reductase; P5C, pyrroline-5-carboxylate; GSA, glutamic semialdehyde; P5CDH, pyrroline-5-carboxylate dehydrogenase; P5CS, pyrroline-5 ...
Brian Suárez Mantilla (435600) +8 more
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