Results 41 to 50 of about 2,628 (173)

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

Frontiers in Pharmacology, 2018
Propolis evokes several therapeutic properties, including anticancer activity. These activities are attributed to the action of polyphenols. Previously it has been demonstrated, that one of the most abundant polyphenolic compounds in ethanolic extracts ...
Katarzyna Celińska-Janowicz, Ilona Zaręba, Urszula Lazarek, Joanna Teul, Michał Tomczyk, Jerzy Pałka, Wojciech Miltyk   +6 more
doaj   +1 more source

AtPAN: an integrated system for reconstructing transcriptional regulatory networks in Arabidopsis thaliana [PDF]

, 2012
Background Construction of transcriptional regulatory networks (TRNs) is of priority concern in systems biology. Numerous high-throughput approaches, including microarray and next-generation sequencing, are extensively adopted to examine transcriptional ...
Yi-An Chen, Ying-Chi Wen, Wen-Chi Chang
core   +2 more sources

Proline dehydrogenase (PRODH) is a differentially expressed gene in brain metastatic human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
openaire   +2 more sources

Electrochemical behavior of dye-linked L-proline dehydrogenase on glassy carbon electrodes modified by multi-walled carbon nanotubes

Beilstein Journal of Nanotechnology, 2010
A glassy carbon electrode (GC) was modified by multi-walled carbon nanotubes (MWCNTs). The modified electrode showed a pair of redox peaks that resulted from the oxygen-containing functional groups on the nanotube surface.
Haitao Zheng, Leyi Lin, Yosuke Okezaki, Ryushi Kawakami, Haruhiko Sakuraba, Toshihisa Ohshima, Keiichi Takagi, Shin-ichiro Suye   +7 more
doaj   +1 more source

SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants [PDF]

, 2015
Metabolic adjustment to changing environmental conditions, particularly balancing of growth and defense responses, is crucial for all organisms to survive.
Anrather, Dorothea, Baena González, Elena, Chaban, Christina, Dietrich, Katrin, Dröege-Laser, Wolfgang, Hanson, Johannes, Kirchler, Tobias, Mair, Andrea, Naegele, Thomas, Pedrotti, Lorenzo, Simeunovic, Andrea, Teige, Markus, Valerio, Concetta, Vicente Carbajosa, Jesus, Weckwerth, Wolfram, Weiste, Christoph, Wurzinger, Bernhard   +16 more
core   +1 more source

Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model

Cellular Physiology and Biochemistry, 2017
Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Ilona Zareba, Arkadiusz Surazynski, Marcin Chrusciel, Wojciech Miltyk, Milena Doroszko, Nafis Rahman, Jerzy Palka   +6 more
doaj   +1 more source

Structural and functional studies of proline catabolic enzymes and human aldehyde dehydrogenases [PDF]

Oxidation of amino acids, like proline catabolism, is a central part of energy metabolism. Proline is oxidized to glutamate by two enzymes: proline dehydrogenase (PRODH) and 1-pyrroline-5-carboxylate dehydrogenase (P5CDH).
Luo, Min
core   +1 more source

Disrupted working memory circuitry and psychotic symptoms in 22q11.2 deletion syndrome. [PDF]

, 2014
22q11.2 deletion syndrome (22q11DS) is a recurrent genetic mutation that is highly penetrant for psychosis. Behavioral research suggests that 22q11DS patients exhibit a characteristic neurocognitive phenotype that includes differential impairment in ...
Bearden, CE, Chow, C, Hilton, AE, Ibrahim, A, Jonas, RK, Karlsgodt, KH, Montojo, CA, Vesagas, TK   +7 more
core   +2 more sources

L-Proline Activates Mammalian Target of Rapamycin Complex 1 and Modulates Redox Environment in Porcine Trophectoderm Cells

Biomolecules, 2021
L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu, Ying Yang, Xuemeng Si, Hai Jia, Yunchang Zhang, Da Jiang, Zhaolai Dai, Zhenlong Wu   +7 more
doaj   +1 more source

Drought tolerance and antioxidant enzymatic activity in transgenic ?Swingle? citrumelo plants over-accumulating proline. [PDF]

, 2011
In this study we investigated the effects of the high endogenous proline level on water relations, gas exchange and antioxidant enzymatic activity in leaves of transgenic ?Swingle?
BESPALHOK FILHO, J. C., CAMPOS, M. K. F. de, CARVALHO, K. de, MARUR, C. J., PEREIRA, L. F. P., SOUZA, F. S. de, VIEIRA, L. G. E.   +6 more
core   +1 more source