Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line. [PDF]
PLoS ONE, 2018 L-Proline is a multifunctional amino acid that plays an essential role in primary metabolism and physiological functions. Proline is oxidized to glutamate in the mitochondria and the FAD-containing enzyme proline oxidase (PO) catalyzes the first step in ...
Pamela Cappelletti +5 more
doaj +6 more sources
NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells [PDF]
International Journal of Molecular Sciences, 2022 Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activated
Adam Kazberuk +2 more
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Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line [PDF]
International Journal of Molecular Sciences, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells.
Ilona Zaręba +2 more
exaly +7 more sources
Involvement of proline oxidase (PutA) in programmed cell death of Xanthomonas. [PDF]
PLoS ONE, 2014 Xanthomonas campestris strains have been reported to undergo programmed cell death (PCD) in a protein rich medium. Protein hydrolysates used in media such as nutrient broth comprise of casein digest with abundance of proline and glutamate. In the current
Surbhi Wadhawan +2 more
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Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line [PDF]
Frontiers in Molecular Biosciences, 2023 Cancer of the corpus uteri and cervix uteri, collectively ranks second among new cancer cases in women after breast cancer. Therefore, investigation of new anticancer agents and identifying new molecular targets presents a challenge to improve ...
Lukasz Szoka +3 more
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Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy [PDF]
Amino Acids, 2021 AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Jerzy Palka +2 more
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Longevity Regulation by Proline Oxidation in Yeast [PDF]
Microorganisms, 2021 Proline is a pivotal and multifunctional amino acid that is used not only as a nitrogen source but also as a stress protectant and energy source. Therefore, proline metabolism is known to be important in maintaining cellular homeostasis.
Akira Nishimura +5 more
doaj +4 more sources
Alleviation of Phytophthora capsici-induced oxidatıve stress by foliarly applied proline in Capsicum annuum L. [PDF]
Archives of Biological Sciences, 2017 Phytophthora capsici is a highly destructive pathogen of pepper. To examine whether proline modifies the levels of plant defense compounds produced in response to P. capsici-induced stress, pepper seedlings were infected with P.
Koç Esra
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The proline regulatory axis and cancer
Frontiers in Oncology, 2012 Studies in metabolism and cancer have characterized changes in core pathways involving glucose and glutamine, emphasizing the provision of substrates for building cell mass.
James Ming Phang
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Hepatocyte nuclear factors 1α and 4α control expression of proline oxidase in adult liver
FEBS Letters, 2004 Adult liver functions are regulated by several hepatocyte nuclear factors (HNFs). HNF4α and HNF1α are involved in metabolic functions in the liver. The expression of proline oxidase (PO) and proline dehydrogenase was downregulated in the HNF4α liver ...
Akihide Kamiya +2 more
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