Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line [PDF]
Frontiers in Molecular Biosciences, 2023 Cancer of the corpus uteri and cervix uteri, collectively ranks second among new cancer cases in women after breast cancer. Therefore, investigation of new anticancer agents and identifying new molecular targets presents a challenge to improve ...
Valery Isidorov +2 more
exaly +6 more sources
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line. [PDF]
PLoS ONE, 2018 L-Proline is a multifunctional amino acid that plays an essential role in primary metabolism and physiological functions. Proline is oxidized to glutamate in the mitochondria and the FAD-containing enzyme proline oxidase (PO) catalyzes the first step in ...
Pamela Cappelletti +5 more
doaj +6 more sources
NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells [PDF]
International Journal of Molecular Sciences, 2022 Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activated
Magda Chalecka +2 more
exaly +6 more sources
Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line [PDF]
International Journal of Molecular Sciences, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells.
Wojciech Miltyk +2 more
exaly +7 more sources
Involvement of proline oxidase (PutA) in programmed cell death of Xanthomonas. [PDF]
PLoS ONE, 2014 Xanthomonas campestris strains have been reported to undergo programmed cell death (PCD) in a protein rich medium. Protein hydrolysates used in media such as nutrient broth comprise of casein digest with abundance of proline and glutamate. In the current
Surbhi Wadhawan +2 more
doaj +4 more sources
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy [PDF]
Amino Acids, 2021 AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Ilona Oscilowska +2 more
exaly +5 more sources
Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells [PDF]
Amino Acids, 2021 Izabela Prokop-Bielenia +2 more
exaly +2 more sources
Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy [PDF]
Molecular and Cellular Biochemistry, 2020 Thi Yen Ly Huynh +2 more
exaly +2 more sources
A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor [PDF]
Pharmacological Reports, 2020 Ilona Oscilowska +2 more
exaly +2 more sources
Physiological and biochemical characteristics of some therophyllous species of the Ficus genus in water stress conditions [PDF]
BIO Web of Conferences, 2021 The relevance of the search for physiological and biochemical parameters associated with the implementation of plant adaptation mechanisms to the combined action of high temperatures and water stress is dictated by frequent summer droughts in southern ...
Grebennikova Oksana, Pilkeviсh Ruslana
doaj +1 more source