Results 41 to 50 of about 29,796 (189)

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate [PDF]

Amino Acids, 2015
Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship between PRODH/POX and regulation of ...
Hancock, Chad N., Liu, Wei, Alvord, W. Gregory, Phang, James M.   +3 more
openaire   +2 more sources

Croatian produced unifloral honey characterized according to the protein and proline content and enzyme activities

Journal of Apicultural Science, 2016
In honey, the content of proteins, including the enzymes, is relatively low and has a minor nutritive significance. On the other hand, the proteins, including the enzymes, are usually used as honey quality evaluation parameters.
Flanjak Ivana, Strelec Ivica, Kenjerić Daniela, Primorac Ljiljana   +3 more
doaj   +1 more source

Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model

Cellular Physiology and Biochemistry, 2017
Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Ilona Zareba, Arkadiusz Surazynski, Marcin Chrusciel, Wojciech Miltyk, Milena Doroszko, Nafis Rahman, Jerzy Palka   +6 more
doaj   +1 more source

Modulating the antioxidant defense systems and nutrients content by proline for higher yielding of wheat under water deficit

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023
Numerous plant metabolites, especially amino acids, are accumulated as a result of stress. These amino acids are crucial for plant metabolism and development and have historically been viewed as the building blocks of proteins. Several studies suggested
Maha L. HADID, Khaled M.A. RAMADAN, Hossam S. EL-BELTAGI, Amany A. RAMADAN, Ibrahim M. EL-METWALLY, Tarek A. SHALABY, Eslam S.A. BENDARY, Khairiah MUBARAK ALWUTAYD, Hani S. SAUDY   +8 more
doaj   +1 more source

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers [PDF]

Cancer Research, 2009
Abstract Tumor metabolism and bioenergetics have become important topics for cancer research and are promising targets for anticancer therapy. Although glucose serves as the main source of energy, proline, an alternative substrate, is important, especially during nutrient stress.
Yongmin, Liu, Gregory L, Borchert, Steven P, Donald, Bhalchandra A, Diwan, Miriam, Anver, James M, Phang   +5 more
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Pretreatment of Sesame Seed (Sesamum indicum L.) with Proline and its Effective on Seed Germination and Plant Physiological Defense Systems under Different Temperature Regimes [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2016
To study the effects of proline and temperature on the rates of antioxidant enzymes and germination index, a factorial laboratory experiment based on completely randomized design was conducted with three replications at the Mohaghegh Ardabili University ...
Nasibeh Tavakoli, Ali Ebadi, Hourieh Tavakoli, Payam Tizfahm   +3 more
doaj  

Comparative Proteomics Analysis between Maize and Sorghum Uncovers Important Proteins and Metabolic Pathways Mediating Drought Tolerance

Life, 2023
Drought severely affects crop yield and yield stability. Maize and sorghum are major crops in Africa and globally, and both are negatively impacted by drought. However, sorghum has a better ability to withstand drought than maize.
Ali Elnaeim Elbasheir Ali, Lizex Hollenbach Husselmann, David L. Tabb, Ndiko Ludidi   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source