Understanding the Role of Key Amino Acids in Regulation of Proline Dehydrogenase/Proline Oxidase (Prodh/Pox)-Dependent Apoptosis/Autophagy as an Approach to Targeted Cancer Therapy [PDF]
Molecular and Cellular Biochemistry, 2020 Thi Yen Ly Huynh +2 more
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Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. [PDF]
Oncotarget, 2018 Proline degradation by proline dehydrogenase/proline oxidase (PRODH/POX) contributes to apoptosis or autophagy. The identification of specific pathway of apoptosis/survival regulation is the aim of this study. We generated knocked-down PRODH/POX MCF-7 breast cancer cells (MCF-7shPRODH/POX). PRODH/POX silencing did not affect cell viability. However, it
Zareba I +4 more
europepmc +4 more sources
Physiological and biochemical characteristics of some therophyllous species of the Ficus genus in water stress conditions [PDF]
BIO Web of Conferences, 2021 The relevance of the search for physiological and biochemical parameters associated with the implementation of plant adaptation mechanisms to the combined action of high temperatures and water stress is dictated by frequent summer droughts in southern ...
Grebennikova Oksana, Pilkeviсh Ruslana
doaj +1 more source
PPARγ and Proline Oxidase in Cancer [PDF]
PPAR Research, 2008 Proline is metabolized by its own specialized enzymes with their own tissue and subcellular localizations and mechanisms of regulation. The central enzyme in this metabolic system is proline oxidase, a flavin adenine dinucleotide‐containing enzyme which is tightly bound to mitochondrial inner membranes.
Phang, James M. +3 more
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Resolving the hydride transfer pathway in oxidative conversion of proline to pyrrole [PDF]
, 2021 Thiotemplated pyrrole is a prevailing intermediate in the synthesis of numerous natural products where the pyrrole is tethered to a carrier protein (CP). Biosynthesis of the pyrrole requires oxidation of an L-proline side chain.
Dongqi, Yi +4 more
core +2 more sources
Effect of drought stress on biochemical contents and proline metabolizing enzymes of Pennisetum glaucum L. [PDF]
Innovations in Agriculture, 2021 Drought stress is one of the major environmental problem affecting agricultural production in arid and semi-arid regions of the world. In present study, the effect of drought stress on Pennisetum glaucum L. (Pearl millet) plants was studied.
S. Suganthi +3 more
doaj +3 more sources
Alleviation of Phytophthora capsici-induced oxidatıve stress by foliarly applied proline in Capsicum annuum L. [PDF]
Archives of Biological Sciences, 2017 Phytophthora capsici is a highly destructive pathogen of pepper. To examine whether proline modifies the levels of plant defense compounds produced in response to P. capsici-induced stress, pepper seedlings were infected with P.
Koç Esra
doaj +1 more source
Proline-Aromatic Sequences Stabilize Turns via C–H/π interactions in both cis-Proline and trans-Proline [PDF]
, 2023 In proteins, proline-aromatic sequences exhibit increased frequencies of cis-proline amide bonds, via proposed C–H/π interactions between the aromatic ring and either the proline ring or the backbone C–Hα of the residue prior to proline.
Michael B., Elbaum +2 more
core +2 more sources
Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
Frontiers in Molecular Biosciences, 2022 Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Thi Yen Ly Huynh +8 more
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Proline Oxidase and Water Stress-induced Proline Accumulation in Spinach Leaves [PDF]
Plant Physiology, 1979 Spinach (Spinacia oleracea L.) leaf discs accumulated free proline when exposed to polyethylene glycol solutions of water potential less than -10 bars. At -20 bars, the accumulation was 11 micromoles per gram original fresh weight in a 24-hour period.When the leaf organelles were separated on a sucrose gradient, a proline oxidase was detected in the ...
A H, Huang, A J, Cavalieri
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