Proline dehydrogenase (oxidase) in cancer
BioFactors, 2012 AbstractProline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the proline degradative pathway, plays a special role in tumorigenesis and tumor development. Proline metabolism catalyzed by PRODH/POX is closely linked with the tricarboxylic acid (TCA) cycle and urea cycle.
Wei, Liu, James M, Phang
openaire +5 more sources
Regulation and function of proline oxidase under nutrient stress [PDF]
Journal of Cellular Biochemistry, 2009 AbstractUnder conditions of nutrient stress, cells switch to a survival mode catabolizing cellular and tissue constituents for energy. Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by ...
Jui, Pandhare +3 more
openaire +4 more sources
Regulation of proline oxidase activity by lactate. [PDF]
Proceedings of the National Academy of Sciences, 1977 We found that proline oxidase, the first enzyme of the proline degradative pathway, is inhibited by lactate. The Km of the enzyme for proline increases with increasing concentrations of lactate. Since proline can be a source for gluconeogenesis, regulation of proline degradation by lactate may serve as a mechanism for allocation of metabolic fuel ...
E M, Kowaloff +3 more
openaire +4 more sources
Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy. [PDF]
Mol Cell Biochem, 2020 Huynh TYL +4 more
europepmc +2 more sources
Physiological and biochemical characteristics of some therophyllous species of the Ficus genus in water stress conditions [PDF]
BIO Web of Conferences, 2021 The relevance of the search for physiological and biochemical parameters associated with the implementation of plant adaptation mechanisms to the combined action of high temperatures and water stress is dictated by frequent summer droughts in southern ...
Grebennikova Oksana, Pilkeviсh Ruslana
doaj +1 more source
A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor. [PDF]
Pharmacol Rep, 2020 Kazberuk A +3 more
europepmc +2 more sources
Effect of drought stress on biochemical contents and proline metabolizing enzymes of Pennisetum glaucum L. [PDF]
Innovations in Agriculture, 2021 Drought stress is one of the major environmental problem affecting agricultural production in arid and semi-arid regions of the world. In present study, the effect of drought stress on Pennisetum glaucum L. (Pearl millet) plants was studied.
S. Suganthi +3 more
doaj +3 more sources
PPARγ and Proline Oxidase in Cancer [PDF]
PPAR Research, 2008 Proline is metabolized by its own specialized enzymes with their own tissue and subcellular localizations and mechanisms of regulation. The central enzyme in this metabolic system is proline oxidase, a flavin adenine dinucleotide‐containing enzyme which is tightly bound to mitochondrial inner membranes.
Phang, James M. +3 more
openaire +2 more sources
Alleviation of Phytophthora capsici-induced oxidatıve stress by foliarly applied proline in Capsicum annuum L. [PDF]
Archives of Biological Sciences, 2017 Phytophthora capsici is a highly destructive pathogen of pepper. To examine whether proline modifies the levels of plant defense compounds produced in response to P. capsici-induced stress, pepper seedlings were infected with P.
Koç Esra
doaj +1 more source
Longevity Regulation by Proline Oxidation in Yeast
Microorganisms, 2021 Proline is a pivotal and multifunctional amino acid that is used not only as a nitrogen source but also as a stress protectant and energy source. Therefore, proline metabolism is known to be important in maintaining cellular homeostasis.
Akira Nishimura +5 more
doaj +1 more source