Results 31 to 40 of about 204,753 (161)

Beneficial Effect of Proline Supplementation on Goat Spermatozoa Quality during Cryopreservation

Animals, 2022
Sperm cryopreservation contributes to the extensive utilization of artificial insemination (AI) in the daily livestock industry. However, due to the presence of few sperm with good biological function in post-thaw goat sperm, its use has been limited for
Weijing Zhang, Lingjiang Min, Yajing Li, Yaning Lang, S. A. Masudul Hoque, Adedeji Olufemi Adetunji, Zhendong Zhu   +6 more
doaj   +1 more source

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. [PDF]

PLoS ONE, 2013
The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Ivan Raimondi, Yari Ciribilli, Paola Monti, Alessandra Bisio, Loredano Pollegioni, Gilberto Fronza, Alberto Inga, Paola Campomenosi   +7 more
doaj   +1 more source

Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline

Antioxidants, 2022
Mitochondrial complex I can produce large quantities of reactive oxygen species (ROS) by reverse electron transfer (RET) from the ubiquinone (UQ) pool.
Kevin Wang, Jonathan Hirschenson, Amanda Moore, Ryan J. Mailloux   +3 more
doaj   +1 more source

Emerging Roles of De Novo Proline Biosynthesis in Human Diseases. [PDF]

FASEB Bioadv
De novo proline synthesis, a multi‐step biochemical pathway starting from glutamate, supplies essential protein building blocks. It supports redox balance, cell proliferation, signal transduction, and nucleotide and protein biosynthesis. This tightly regulated pathway, governed by conserved mechanisms, is disrupted in diseases such as cancer and ...
Pei E, Ma J.
europepmc   +2 more sources

Mycorrhizal-mediated lower proline accumulation in Poncirus trifoliata under water deficit derives from the integration of inhibition of proline synthesis with increase of proline degradation. [PDF]

PLoS ONE, 2013
Proline accumulation was often correlated with drought tolerance of plants infected by arbuscular mycorrhizal fungi (AMF), whereas lower proline in some AM plants including citrus was also found under drought stress and the relevant mechanisms have not ...
Ying-Ning Zou, Qiang-Sheng Wu, Yong-Ming Huang, Qiu-Dan Ni, Xin-Hua He   +4 more
doaj   +1 more source

Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells

Biomolecules, 2021
It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh, Ilona Oscilowska, Jorge Sáiz, Magdalena Nizioł, Weronika Baszanowska, Coral Barbas, Jerzy Palka   +6 more
doaj   +1 more source

NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells

, 2022
Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activated
Arkadiusz Surazynski, Jerzy Palka, Katarzyna Bielawska, Adam Kazberuk, Magda Chalecka   +4 more
core   +1 more source

Supplementation of 2-Ap, Zn and La Improves 2-Acetyl-1-Pyrroline Concentrations in Detached Aromatic Rice Panicles In Vitro. [PDF]

PLoS ONE, 2016
Aromatic rice is highly prized by consumers worldwide due to its special aromatic character. 2-acetyl-1-pyrroline (2-AP) is considered to be the single most important volatile compound responsible for aroma in aromatic rice.
Zhaowen Mo, Jinxia Huang, Di Xiao, Umair Ashraf, Meiyang Duan, Shenggang Pan, Hua Tian, Lizhong Xiao, Keyou Zhong, Xiangru Tang   +9 more
doaj   +1 more source

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade

Cell Reports, 2016
Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders.
Gregg W. Crabtree, Alan J. Park, Joshua A. Gordon, Joseph A. Gogos   +3 more
doaj   +1 more source

Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by SHeterocycles

, 2021
Proline dehydrogenase (PRODH) is a flavoenzyme that catalyzes the first step of proline catabolism, the oxidation of l-proline to Δ1-pyrroline-5-carboxylate.
Austin R. Prater, Kent S. Gates, Alexandra N. Bogner (11456913), Ashley C. Campbell, Ashley C. Campbell (8594925), Austin R. Prater (5003903), Thomas P. Quinn (7851794), Alexandra N. Bogner, John J. Tanner, Kent S. Gates (1310250), John J. Tanner (1333191), Thomas P. Quinn, Donald F. Becker, Donald F. Becker (742832)   +13 more
core   +1 more source