Results 21 to 30 of about 2,628 (173)

Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells

Biology, 2021
It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Sylwia Lewoniewska, Ilona Oscilowska, Antonella Forlino, Jerzy Palka   +3 more
doaj   +1 more source

Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion. [PDF]

Cancer Med
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Yajima S, Tsukada Y, Yamashita R, Fujisawa T, Kuwata T, Watanabe R, Ishii G, Gabelia N, Juhl H, Koga Y, Yoshino T, Ito M, Masuda H.   +12 more
europepmc   +2 more sources

Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells

Frontiers in Molecular Biosciences, 2022
Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Thi Yen Ly Huynh, Ilona Oscilowska, Lukasz Szoka, Ewelina Piktel, Weronika Baszanowska, Katarzyna Bielawska, Robert Bucki, Wojciech Miltyk, Jerzy Palka   +8 more
doaj   +1 more source

Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities

Frontiers in Plant Science, 2020
Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton, Cécile Cabassa-Hourton, Arnould Savouré, Dietmar Funck, Giuseppe Forlani   +4 more
doaj   +1 more source

ACTCAT, a Novel cis-Acting Element for Proline- and Hypoosmolarity-Responsive Expression of theProDHGene Encoding Proline Dehydrogenase in Arabidopsis [PDF]

Plant Physiology, 2002
AbstractProline (Pro) is one of the most widely distributed osmolytes in water-stressed plants. We previously isolated from Arabidopsis a gene encoding Pro dehydrogenase (ProDH), a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid. The ProDH gene in Arabidopsis is up-regulated by rehydration after dehydration but
Rie, Satoh, Kazuo, Nakashima, Motoaki, Seki, Kazuo, Shinozaki, Kazuko, Yamaguchi-Shinozaki   +4 more
openaire   +2 more sources

Beneficial Effect of Proline Supplementation on Goat Spermatozoa Quality during Cryopreservation

Animals, 2022
Sperm cryopreservation contributes to the extensive utilization of artificial insemination (AI) in the daily livestock industry. However, due to the presence of few sperm with good biological function in post-thaw goat sperm, its use has been limited for
Weijing Zhang, Lingjiang Min, Yajing Li, Yaning Lang, S. A. Masudul Hoque, Adedeji Olufemi Adetunji, Zhendong Zhu   +6 more
doaj   +1 more source

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. [PDF]

PLoS ONE, 2013
The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Ivan Raimondi, Yari Ciribilli, Paola Monti, Alessandra Bisio, Loredano Pollegioni, Gilberto Fronza, Alberto Inga, Paola Campomenosi   +7 more
doaj   +1 more source

Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline

Antioxidants, 2022
Mitochondrial complex I can produce large quantities of reactive oxygen species (ROS) by reverse electron transfer (RET) from the ubiquinone (UQ) pool.
Kevin Wang, Jonathan Hirschenson, Amanda Moore, Ryan J. Mailloux   +3 more
doaj   +1 more source

Mycorrhizal-mediated lower proline accumulation in Poncirus trifoliata under water deficit derives from the integration of inhibition of proline synthesis with increase of proline degradation. [PDF]

PLoS ONE, 2013
Proline accumulation was often correlated with drought tolerance of plants infected by arbuscular mycorrhizal fungi (AMF), whereas lower proline in some AM plants including citrus was also found under drought stress and the relevant mechanisms have not ...
Ying-Ning Zou, Qiang-Sheng Wu, Yong-Ming Huang, Qiu-Dan Ni, Xin-Hua He   +4 more
doaj   +1 more source

Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells

Biomolecules, 2021
It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh, Ilona Oscilowska, Jorge Sáiz, Magdalena Nizioł, Weronika Baszanowska, Coral Barbas, Jerzy Palka   +6 more
doaj   +1 more source