Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism [PDF]
Advanced Science, Volume 13, Issue 19, 2 April 2026.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +2 more sources
VK-2019 enhances gemcitabine’s antitumor activity in EBV-positive nasopharyngeal carcinoma by upregulating PRODH expression [PDF]
Cell Death DiscoveryNasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-driven malignancy, making the viral protein EBNA1 a pivotal therapeutic target. This study evaluates VK-2019, a clinical-stage EBNA1 inhibitor, for its potential to sensitize NPC cells to ...
Chengxun Li +4 more
doaj +2 more sources
Food and Energy SecurityRice‐crayfish system (RCS) is an integrated farming technology that benefits grain production, food safety, and green sustainable agricultural development.
Bin Du +8 more
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Proline–Nitrogen Metabolic Coordination Mediates Cold Priming-Induced Freezing Tolerance in Maize [PDF]
PlantsCold stress critically restricts maize seedling growth in Northeast China, yet the mechanism by which cold priming (CP) enhances cold tolerance through proline–nitrogen metabolic networks remains unclear.
Zhijia Gai +9 more
doaj +2 more sources
Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. [PDF]
PLoS ONE, 2013 Proline dehydrogenase (Prodh) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5Cdh) are two key enzymes in the cellular biogenesis of glutamate.
Ziting Yao +6 more
doaj +1 more source
Biology, 2021 It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Sylwia Lewoniewska +3 more
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Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
Frontiers in Molecular Biosciences, 2022 Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Thi Yen Ly Huynh +8 more
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ACTCAT, a Novel cis-Acting Element for Proline- and Hypoosmolarity-Responsive Expression of theProDHGene Encoding Proline Dehydrogenase in Arabidopsis [PDF]
Plant Physiology, 2002 AbstractProline (Pro) is one of the most widely distributed osmolytes in water-stressed plants. We previously isolated from Arabidopsis a gene encoding Pro dehydrogenase (ProDH), a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid. The ProDH gene in Arabidopsis is up-regulated by rehydration after dehydration but
Rie, Satoh +4 more
openaire +2 more sources
Frontiers in Plant Science, 2020 Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton +4 more
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P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. [PDF]
PLoS ONE, 2013 The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Ivan Raimondi +7 more
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