Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy [PDF]
Molecular and Cellular Biochemistry, 2020 AbstractIn stress conditions, as neoplastic transformation, amino acids serve not only as nutrients to maintain the cell survival but also as mediators of several regulatory pathways which are involved in apoptosis and autophagy. Especially, under glucose deprivation, in order to maintain the cell survival, proline and glutamine together with other ...
Thi Yen Ly Huynh +2 more
exaly +3 more sources
Proline dehydrogenase (PRODH) is a differentially expressed gene in brain metastatic human breast cancer. [PDF]
, 2021 Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
Shahan Mamoor
openaire +3 more sources
Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities [PDF]
Frontiers in Plant Science, 2020 Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton +4 more
doaj +2 more sources
Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis [PDF]
European Journal of Human Genetics, 2006 Schizophrenia is a devastating psychiatric disease that affects up to 1% of the population worldwide. Recent studies suggested that schizophrenia might result from the hypofunction of glutamatergic neurotransmission. Systematic positional, expression and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline ...
Lin He
exaly +3 more sources
Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells [PDF]
Biology, 2021 It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Sylwia Lewoniewska +3 more
doaj +2 more sources
Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Ilona Zareba +6 more
doaj +5 more sources
Production of Recombinant Proline Dehydrogenase Enzyme from Pseudomonas fluorescens pf-5 in E. coli System [PDF]
Journal of Sciences, Islamic Republic of Iran, 2011 Proline dehydrogenase (ProDH; 1.5.99.8) belongs to superfamily of amino acid dehydrogenase, which plays a significant role in the metabolic pathway from proline to glutamate. The goal of this research was gene cloning and characterization of ProDH enzyme
E. Omidinia
doaj +2 more sources
Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline [PDF]
Molecules, 2017 Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick +4 more
doaj +3 more sources
Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
Frontiers in Molecular Biosciences, 2022 Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Wojciech Miltyk +2 more
exaly +3 more sources
P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. [PDF]
PLoS ONE, 2013 The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Ivan Raimondi +7 more
doaj +3 more sources