Context of Action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis [PDF]
BMC Plant Biology, 2014 La proline (Pro) déshydrogénase (ProDH) potentialise l'éclatement oxydatif et la mort cellulaire de la réponse hypersensible (RH) de la plante par des mécanismes non encore élucidés. ProDH convertit Pro en ∆1 pyrroline-5-carboxylate (P5C) et peut agir conjointement avec la P5C déshydrogénase (P5CDH) pour produire Glu, ou avec la P5C réductase (P5CR ...
María Elena Alvarez +2 more
exaly +5 more sources
Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence [PDF]
International Journal of Molecular SciencesThe identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and mortality.
Maria Teresa Palano +2 more
exaly +5 more sources
Identification of a Candidate PRODH Allosteric Inhibitor MBTP-15324: Modulation of Proline Metabolite Profiles and ECM-Associated Gene-Expression Changes in Lung Cancer Cells. [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryCurrent proline dehydrogenase (PRODH) inhibitors lack scaffold diversity. Through virtual screening, microscale thermophoresis, and molecular dynamics simulations, we identified MBTP-15324 as a candidate novel PRODH allosteric inhibitor (Kd = 1.45 μM ...
Yonglong Han, Guo Cheng, Quanjun Yang
exaly +4 more sources
Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line [PDF]
International Journal of Molecular Sciences, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells. PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation of cancer cell survival/apoptosis. The enzyme is activated by AMP kinase (AMPK). It has been found that
Wojciech Miltyk +2 more
exaly +4 more sources
Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations [PDF]
The Ukrainian Biochemical Journal, 2020 Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes.
F. H. Moghadam +7 more
doaj +2 more sources
Understanding the Role of Key Amino Acids in Regulation of Proline Dehydrogenase/Proline Oxidase (Prodh/Pox)-Dependent Apoptosis/Autophagy as an Approach to Targeted Cancer Therapy [PDF]
Molecular and Cellular Biochemistry, 2020 AbstractIn stress conditions, as neoplastic transformation, amino acids serve not only as nutrients to maintain the cell survival but also as mediators of several regulatory pathways which are involved in apoptosis and autophagy. Especially, under glucose deprivation, in order to maintain the cell survival, proline and glutamine together with other ...
Thi Yen Ly Huynh +2 more
exaly +3 more sources
Frontiers in Oncology, 2023 Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Guang Ji, Guangtao Zhang
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Association Study of the G-Protein Signaling 4 (RGS4) and Proline Dehydrogenase (PRODH) Genes With Schizophrenia: A Meta-Analysis [PDF]
European Journal of Human Genetics, 2006 Schizophrenia is a devastating psychiatric disease that affects up to 1% of the population worldwide. Recent studies suggested that schizophrenia might result from the hypofunction of glutamatergic neurotransmission. Systematic positional, expression and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline ...
Lin He
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Cellular Physiology and Biochemistry, 2017 Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Wojciech Miltyk +2 more
exaly +3 more sources
Proline Dehydrogenase Gene TaProDH1 Positively Regulates Wheat Resistance to Stripe Rust Disease [PDF]
Journal of FungiProline dehydrogenase (ProDH) is a rate-limiting enzyme in the proline metabolism cycle that plays an important role in plant stress response and disease resistance. However, the function and mechanism of ProDH1 in the wheat–Puccinia striiformis f.
Haibin Zhao +4 more
doaj +2 more sources