PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer [PDF]
Pharmaceuticals, 2021 Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Wojciech Miltyk +2 more
exaly +7 more sources
P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions [PDF]
Frontiers in Plant Science, 2015 Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Maria Elena Alvarez +2 more
exaly +9 more sources
Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
Frontiers in Molecular Biosciences, 2022 Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Wojciech Miltyk +2 more
exaly +5 more sources
PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production [PDF]
EMBO ReportsNaive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Meihua Sui, Ying-Jie Wang, Cheng Chen
exaly +3 more sources
Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells [PDF]
Biomolecules, 2021 It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh +2 more
exaly +4 more sources
Frontiers in Immunology, 2023 BackgroundThe shortened life expectancy in schizophrenia (SCZ) patients may be correlated with most cancers, yet there is heterogeneity in the studies examining these correlations. This study explored the expression of SCZ-related genes (HTR2A, COMT, and
Jing Shen +7 more
exaly +3 more sources
Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase [PDF]
MoleculesThe proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks +3 more
doaj +2 more sources
Integrated Proteomics and Metabolomics Reveal Spermine Enhances Sperm Freezability via Antioxidant Pathways [PDF]
AntioxidantsSperm freezability exhibits marked individual variability, yet the mechanisms remain unclear. Using bulls as the experimental model, we integrated proteomic (sperm) and metabolomic (seminal plasma) analyses of high-freezability (HF) and control (CF ...
Lewei Guo +12 more
doaj +2 more sources
Genetic variations in amino acid metabolism-related genes are associated with risk of papillary thyroid carcinoma: a case-control study [PDF]
BMC Endocrine DisordersBackground Abnormal amino acid metabolic pathways, especially those of glutamine, serine and proline, are crucial to tumourigenesis and the development of papillary thyroid carcinoma (PTC).
Hongjing Meng +4 more
doaj +2 more sources
Frontiers in Oncology, 2023 Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Xiangyuan Xu +10 more
doaj +1 more source