Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Arkadiusz Surazynski +6 more
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Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2003 People with deletion of the chromosome 22q11 region associated with velo cardio-facial syndrome (VCFS) have a remarkably high risk of developing schizophrenia.
N. Williams +15 more
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In silico Analysis of PRODH Mutations and their biological significance in disease etiology
Abasyn Journal Life Sciences, 2022 In the present study, we performed in silico analysis on all reported mutations of PRODH in order to investigate their biological significance. 3D models of wildtype and mutant PRODH were predicted using I-TASSER.
Abida Bibi +8 more
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The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD. [PDF]
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016 International audienceThe proline dehydrogenase (PRODH) gene maps to 22q11.2 in the region deleted in the velo-cardio-facial syndrome (VCFS). A moderate to severe reduction (>50%) in PRODH activity resulting from recessive deletions and/or missense ...
Betancur, Catalina +13 more
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Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence [PDF]
The identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and ...
Bruno, Antonino +23 more
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, 2013 A, Morphology of hypovirus-infected Δprodh and Δp5cdh mutants. The strains were cultured on PDA for 7 days; hypovirus was introduced into Δprodh and Δp5cdh from the hypovirus-infected strain EP713 by anastomosis.
Hui Zhou (13228) +6 more
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A Lysine to Alanine Mutant in Escherichia coli PutA Remarkably Reduces Its PRODH Activity
, 2018 The imino acid proline plays a critical function in the oxidative stress response in organisms. The catabolism of proline is catalyzed by two enzymes PRODH and P5CDH, which constitute a single protein known as PutA in gram-negative bacteria.
Thelen, Brandon
core
Intracellular Prodh activity of C. parasitica strains in various culture mediaa.
, 2013 aProdh activity was expressed as 1 μM of P5C formed per min per 100 mg of mycelium. The data are from three replicates.
Hui Zhou (13228) +6 more
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Diagram of the PRODH gene, representing the variants investigated in this study and their locations.
, 2014 Diagram of the PRODH gene, representing the variants investigated in this study and their locations.
Karen M. Yamada (519133) +16 more
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At least two p53 family members control the expression of PRODH in mammalian cells.
, 2013 A. Analysis of PRODH transcript levels after ectopic expression of p53 family members p53, p63β, p73β. Expression constructs for p53, p63β, p73β were transfected in HCT116 p53-/- cells and PRODH transcript induction was assayed by qPCR and compared to ...
Yari Ciribilli (218760) +7 more
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