Results 1 to 10 of about 663 (113)

PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer

Pharmaceuticals, 2021
Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Wojciech Miltyk, Ilona Oscilowska, Jerzy Palka   +2 more
exaly   +4 more sources

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

EMBO Reports
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Meihua Sui, Ying-Jie Wang, Cheng Chen
exaly   +3 more sources

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions [PDF]

Frontiers in Plant Science, 2015
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Maria Elena Alvarez, Georgina Fabro, Mariela Inés Monteoliva   +2 more
exaly   +4 more sources

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. [PDF]

PLoS ONE, 2013
The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Ivan Raimondi, Yari Ciribilli, Paola Monti, Alessandra Bisio, Loredano Pollegioni, Gilberto Fronza, Alberto Inga, Paola Campomenosi   +7 more
doaj   +3 more sources

Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells

Biology, 2021
It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Sylwia Lewoniewska, Ilona Oscilowska, Antonella Forlino, Jerzy Palka   +3 more
doaj   +3 more sources

Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations [PDF]

The Ukrainian Biochemical Journal, 2020
Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes.
F. H. Moghadam, Z. H. A. Mehrabani, M. Amounajaf, S. Rahmanzadeh, F. Ghasemvand, A. S. Samghabadi, A. Nejadmoghaddam, E. Omidinia   +7 more
doaj   +3 more sources

Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model

Frontiers in Immunology, 2023
BackgroundThe shortened life expectancy in schizophrenia (SCZ) patients may be correlated with most cancers, yet there is heterogeneity in the studies examining these correlations. This study explored the expression of SCZ-related genes (HTR2A, COMT, and
Jing Shen, Qiang Wang, Fengquan Lu, Hua Xu, Peng Wang, Yu Feng, Yu Feng, Yu Feng   +7 more
exaly   +3 more sources

Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells

Frontiers in Molecular Biosciences, 2022
Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Wojciech Miltyk, Thi Yen Ly Huynh, Ewelina Piktel   +2 more
exaly   +3 more sources

Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells

Biomolecules, 2021
It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh, Ilona Oscilowska, Jorge Sáiz, Magdalena Nizioł, Weronika Baszanowska, Coral Barbas, Jerzy Palka   +6 more
doaj   +2 more sources

Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy?

Frontiers in Oncology, 2023
Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Xiangyuan Xu, Xiangyuan Xu, Guangtao Zhang, Yijia Chen, Weina Xu, Yujing Liu, Yujing Liu, Guang Ji, Guang Ji, Hanchen Xu, Hanchen Xu   +10 more
doaj   +1 more source