Results 1 to 10 of about 4,962 (199)

Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells

Frontiers in Molecular Biosciences, 2022
Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK ...
Thi Yen Ly Huynh, Katarzyna Bielawska, Lukasz Szoka   +2 more
exaly   +5 more sources

PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer [PDF]

Pharmaceuticals, 2021
Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Magdalena Misiura, Jerzy Palka, Katarzyna Bielawska   +2 more
exaly   +5 more sources

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

EMBO Reports
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Qianyu Liu, Meihua Sui, Cheng Chen
exaly   +4 more sources

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions [PDF]

Frontiers in Plant Science, 2015
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Maria E Alvarez, Nicolás M Cecchini, Mariela Ines Monteoliva   +2 more
exaly   +6 more sources

Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells

Biomolecules, 2021
It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh, Ilona Zareba, Jorge Sáiz   +2 more
exaly   +3 more sources

Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model

Frontiers in Immunology, 2023
BackgroundThe shortened life expectancy in schizophrenia (SCZ) patients may be correlated with most cancers, yet there is heterogeneity in the studies examining these correlations. This study explored the expression of SCZ-related genes (HTR2A, COMT, and
Jing Shen, Qiang Wang, Fengquan Lu, Hua Xu, Peng Wang, Yu Feng, Yu Feng, Yu Feng   +7 more
exaly   +3 more sources

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase [PDF]

Molecules
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks, Alexandra N. Bogner, Jay C. Nix, John J. Tanner   +3 more
doaj   +2 more sources

Integrated Proteomics and Metabolomics Reveal Spermine Enhances Sperm Freezability via Antioxidant Pathways [PDF]

Antioxidants
Sperm freezability exhibits marked individual variability, yet the mechanisms remain unclear. Using bulls as the experimental model, we integrated proteomic (sperm) and metabolomic (seminal plasma) analyses of high-freezability (HF) and control (CF ...
Lewei Guo, Zhuoxuan Gu, Bing Wang, Yunuo Wang, Jiaorong Chen, Yitong Li, Qiuju Zheng, Jing Zhao, He Ding, Hongyu Liu, Yi Fang, Jun Wang, Wenfa Lyu   +12 more
doaj   +2 more sources

Genetic variations in amino acid metabolism-related genes are associated with risk of papillary thyroid carcinoma: a case-control study [PDF]

BMC Endocrine Disorders
Background Abnormal amino acid metabolic pathways, especially those of glutamine, serine and proline, are crucial to tumourigenesis and the development of papillary thyroid carcinoma (PTC).
Hongjing Meng, Zhifu Xiao, Qiang Wang, Dewei Li, Zhuyan Li   +4 more
doaj   +2 more sources

Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy?

Frontiers in Oncology, 2023
Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Xiangyuan Xu, Xiangyuan Xu, Guangtao Zhang, Yijia Chen, Weina Xu, Yujing Liu, Yujing Liu, Guang Ji, Guang Ji, Hanchen Xu, Hanchen Xu   +10 more
doaj   +1 more source