Results 11 to 20 of about 2,833 (174)

PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer [PDF]

Pharmaceuticals, 2021
Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Magdalena Misiura, Ilona Zaręba, Katarzyna Bielawska   +2 more
exaly   +6 more sources

PRODH Regulates Tamoxifen Resistance through Ferroptosis in Breast Cancer Cells [PDF]

Genes
Background: Estrogen receptor-positive breast cancer accounts for around 70% of all cases. Tamoxifen, an anti-estrogenic inhibitor, is the primary drug used for this type of breast cancer treatment.
Ping Zhang, Kuaiying Wu, Xiaofeng Luo
exaly   +5 more sources

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions [PDF]

Frontiers in Plant Science, 2015
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Mariela Inés Monteoliva, Georgina Fabro, Maria Elena Alvarez   +2 more
exaly   +8 more sources

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

EMBO Reports
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Cheng Chen, Qianyu Liu, Meihua Sui
exaly   +3 more sources

Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations [PDF]

The Ukrainian Biochemical Journal, 2020
Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes.
M. Amounajaf, A. Nejadmoghaddam, F. Ghasemvand, Z. H. A. Mehrabani, S. Rahmanzadeh, E. Omidinia, F. H. Moghadam, A. S. Samghabadi   +7 more
core   +3 more sources

Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells [PDF]

Biology, 2021
It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Ilona Oscilowska, Antonella Forlino, Sylwia Lewoniewska, Jerzy Palka   +3 more
core   +6 more sources

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements [PDF]

PLoS ONE, 2013
The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Monti, P., Yari Ciribilli, Alberto Inga (53320), Alessandra Bisio (218766), Paola Campomenosi, Paola Campomenosi (431559), Paola Monti (218762), POLLEGIONI, LOREDANO, Paola Monti, Loredano Pollegioni, Ivan Raimondi (431557), CAMPOMENOSI, PAOLA, Inga, A., Gilberto Fronza, Yari Ciribilli (218760), Raimondi, I., Fronza, G., Gilberto Fronza (218781), Alessandra Bisio, Bisio, A., Ciribilli, Y., Ivan Raimondi, Alberto Inga, Loredano Pollegioni (431558)   +23 more
core   +6 more sources

Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells

Biomolecules, 2021
It has been considered that proline dehydrogenase/proline oxidase (PRODH/POX) is involved in antineoplastic activity of metformin (MET). The aim of this study is identification of key metabolites of glycolysis, pentose phosphate pathway (PPP ...
Thi Yen Ly Huynh, Ilona Zaręba, Jorge Saiz   +2 more
exaly   +4 more sources

PRODH Polymorphisms, Cortical Volumes and Thickness in Schizophrenia

PLoS ONE, 2014
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder.
Denise M Christofolini, Karen M. Yamada (519133), Maria I. Melaragno (519135), João R Sato, Sato, Joao R. [UNIFESP], Bellucco, Fernanda Teixeira da Silva [UNIFESP], Sintia I. Belangero (519136), Rodrigo A. Bressan (291032), Sidney Santos, Smith, Marilia de Arruda Cardoso [UNIFESP], Cristiano Noto, João R. Sato (153911), Sintia I Belangero, Melaragno, Maria I. [UNIFESP], Jackowski, Andrea Parolin [UNIFESP], Sidney Santos (151965), Idaiane B. Assunção (519132), Vanessa K Ota, Mari, Jair de Jesus [UNIFESP], Karen M Yamada, Marília A C Smith, Maria I Melaragno, Marcos L. Santoro (519129), Ribeiro-dos-Santos, Andrea K., Ândrea K. Ribeiro-dos-Santos (519134), Marcos L Santoro, Assunção, Idaiane Batista de [UNIFESP], Andrea K Ribeiro-dos-Santos, Bressan, Rodrigo Affonseca [UNIFESP], Idaiane B Assunção, Rodrigo A Bressan, Andrea P Jackowski, Gadelha, Ary [UNIFESP], Andrea P. Jackowski (516576), Fernanda T Bellucco, Jair J Mari, Yamada, Karen M. [UNIFESP], Ary Gadelha (291025), Ota, Vanessa Kiyomi Arashiro [UNIFESP], Fernanda T. Bellucco (519128), Ary Gadelha, Santoro, Marcos Leite [UNIFESP], Denise M. Christofolini (519131), Belangero, Sintia Iole [UNIFESP], Santos, Sidney, Christofolini, Denise Maria, Noto, Cristiano [UNIFESP], Marília A. C. Smith (5657782), Vanessa K. Ota (519127), Cristiano Noto (519130), Jair J. Mari (309023)   +50 more
core   +5 more sources

Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. [PDF]

PLoS Genetics, 2008
PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome).
Kristin K. Nicodemus, Lucas Kempf, Venkata A. Mattay, Beth A. Verchinski, Michael F. Egan, Richard E Straub, Daniel R. Weinberger, Daniel R Weinberger, Andreas Meyer-Lindenberg, Joseph H Callicott, Beth A Verchinski, Venkata A Mattay, Richard E. Straub, Kristin K Nicodemus, Radhakrishna Vakkalanka, Michael F Egan, Joseph H. Callicott, Bhaskar Kolachana   +17 more
core   +5 more sources