Results 11 to 20 of about 2,842 (177)

PRODH Regulates Tamoxifen Resistance through Ferroptosis in Breast Cancer Cells [PDF]

Genes
Background: Estrogen receptor-positive breast cancer accounts for around 70% of all cases. Tamoxifen, an anti-estrogenic inhibitor, is the primary drug used for this type of breast cancer treatment. However, tamoxifen resistance is a major challenge in clinics.
Bo Lei, Jiajun Cui, Xiaofeng Luo
exaly   +6 more sources

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. [PDF]

PLoS ONE, 2013
The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation.
Ivan Raimondi, Yari Ciribilli, Paola Monti, Alessandra Bisio, Loredano Pollegioni, Gilberto Fronza, Alberto Inga, Paola Campomenosi   +7 more
doaj   +7 more sources

Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations [PDF]

The Ukrainian Biochemical Journal, 2020
Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes.
F. H. Moghadam, Z. H. A. Mehrabani, M. Amounajaf, S. Rahmanzadeh, F. Ghasemvand, A. S. Samghabadi, A. Nejadmoghaddam, E. Omidinia   +7 more
doaj   +4 more sources

Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells [PDF]

Biology, 2021
It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity.
Sylwia Lewoniewska, Ilona Oscilowska, Antonella Forlino, Jerzy Palka   +3 more
doaj   +8 more sources

PRODH polymorphisms, cortical volumes and thickness in schizophrenia. [PDF]

PLoS ONE, 2014
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder.
Vanessa K Ota, Fernanda T Bellucco, Ary Gadelha, Marcos L Santoro, Cristiano Noto, Denise M Christofolini, Idaiane B Assunção, Karen M Yamada, Andrea K Ribeiro-dos-Santos, Sidney Santos, Jair J Mari, Marília A C Smith, Maria I Melaragno, Rodrigo A Bressan, João R Sato, Andrea P Jackowski, Sintia I Belangero   +16 more
doaj   +5 more sources

Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. [PDF]

PLoS Genetics, 2008
PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome).
Lucas Kempf, Kristin K Nicodemus, Bhaskar Kolachana, Radhakrishna Vakkalanka, Beth A Verchinski, Michael F Egan, Richard E Straub, Venkata A Mattay, Joseph H Callicott, Daniel R Weinberger, Andreas Meyer-Lindenberg   +10 more
doaj   +6 more sources

Functional Consequences of PRODH Missense Mutations [PDF]

The American Journal of Human Genetics, 2005
PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation pathway. At least 16 PRODH missense mutations have been identified in studies of type I hyperprolinemia (HPI) and ...
Bender, Hans-Ulrich, Almashanu, Shlomo, Steel, Gary, Hu, Chien-An, Lin, Wei-Wen, Willis, Alecia, Pulver, Ann, Valle, David   +7 more
openaire   +4 more sources

PRODH gene is associated with executive function in schizophrenic families [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractThe aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first‐episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests.
Li, T, Ma, X H, Hu, X, Wang, Y C, Yan, C Y, Meng, H Q, Liu, X H, Toulopoulou, T, Murray, R M, Collier, D A   +9 more
core   +6 more sources

Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis [PDF]

BMC Plant Biology, 2014
La proline (Pro) déshydrogénase (ProDH) potentialise l'éclatement oxydatif et la mort cellulaire de la réponse hypersensible (RH) de la plante par des mécanismes non encore élucidés. ProDH convertit Pro en ∆1 pyrroline-5-carboxylate (P5C) et peut agir conjointement avec la P5C déshydrogénase (P5CDH) pour produire Glu, ou avec la P5C réductase (P5CR ...
Mariela Inés Monteoliva, Yanina Soledad Rizzi, Nicolás M. Cecchini, Mohammad‐Reza Hajirezaei, María Elena Álvarez   +4 more
openaire   +6 more sources

SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression [PDF]

Disease Models & Mechanisms, 2017
Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear.
Liesbeth Zwarts, Veerle Vulsteke, Edgar Buhl, James J. L. Hodge, Patrick Callaerts   +4 more
doaj   +3 more sources