SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression [PDF]
Disease Models & Mechanisms, 2017 Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear.
Liesbeth Zwarts +4 more
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Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Ilona Zareba +6 more
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Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. [PDF]
PLoS Genetics, 2008 PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome).
Lucas Kempf +10 more
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Frontiers in Pharmacology, 2018 Propolis evokes several therapeutic properties, including anticancer activity. These activities are attributed to the action of polyphenols. Previously it has been demonstrated, that one of the most abundant polyphenolic compounds in ethanolic extracts ...
Katarzyna Celińska-Janowicz +6 more
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PRODH polymorphisms, cortical volumes and thickness in schizophrenia. [PDF]
PLoS ONE, 2014 Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder.
Vanessa K Ota +16 more
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Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. [PDF]
PLoS ONE, 2013 Proline dehydrogenase (Prodh) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5Cdh) are two key enzymes in the cellular biogenesis of glutamate.
Ziting Yao +6 more
doaj +1 more source
Functional Consequences of PRODH Missense Mutations [PDF]
, 2005 PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation pathway. At least 16
Hu, Chien-An +7 more
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Frontiers in Plant Science, 2020 Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton +4 more
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Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy [PDF]
, 2018 Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane protein linked to electron transport and capable of generating mitochondrial glutamate and intracellular ATP, especially under cellular stress conditions.
Becker, Beatrice
core +1 more source
Molecular Plant-Microbe Interactions, 2016 Plants activate different defense systems to counteract the attack of microbial pathogens. Among them, the recognition of conserved microbial- or pathogen-associated molecular patterns (MAMPs or PAMPs) by pattern-recognition receptors stimulates MAMP- or
Georgina Fabro +2 more
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