Results 21 to 30 of about 4,962 (199)

Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion. [PDF]

Cancer Med
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Yajima S, Tsukada Y, Yamashita R, Fujisawa T, Kuwata T, Watanabe R, Ishii G, Gabelia N, Juhl H, Koga Y, Yoshino T, Ito M, Masuda H.   +12 more
europepmc   +2 more sources

In Silico Structural Modeling of Wildtype and Mutant PRODH Proteins Involved in Psychiatric Disorder. [PDF]

Proceedings of the National Academy of Sciences, 2021
Abstract Proline dehydrogenase is an important mitochondrial enzyme that is encoded by the PRODH gene. Biologically, a mutation in this gene affects the activity of proline dehydrogenase enzyme that is normally involved in conversion of proline to glutamate.
Muhammad Muzammal, Sumra Wajid Abbasi, Ansar Ahmad Abbasi, Muzammil Ahmad Khan   +3 more
openaire   +4 more sources

PRODH Regulates Tamoxifen Resistance through Ferroptosis in Breast Cancer Cells. [PDF]

Genes (Basel)
Background: Estrogen receptor-positive breast cancer accounts for around 70% of all cases. Tamoxifen, an anti-estrogenic inhibitor, is the primary drug used for this type of breast cancer treatment. However, tamoxifen resistance is a major challenge in clinics.
Zhang P, Qian N, Lai H, Chen S, Wu K, Luo X, Lei B, Liu M, Cui J.   +8 more
europepmc   +3 more sources

Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. [PDF]

PLoS ONE, 2013
Proline dehydrogenase (Prodh) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5Cdh) are two key enzymes in the cellular biogenesis of glutamate.
Ziting Yao, Chengwu Zou, Hui Zhou, Jinzi Wang, Lidan Lu, Yang Li, Baoshan Chen   +6 more
doaj   +1 more source

PRODH mutations and hyperprolinemia in a subset of schizophrenic patients [PDF]

Human Molecular Genetics, 2002
The increased prevalence of schizophrenia among patients with the 22q11 interstitial deletion associated with DiGeorge syndrome has suggested the existence of a susceptibility gene for schizophrenia within the DiGeorge syndrome chromosomal region (DGCR) on 22q11.
Hélène, Jacquet, Grégory, Raux, Florence, Thibaut, Bernadette, Hecketsweiler, Emmanuelle, Houy, Caroline, Demilly, Sadeq, Haouzir, Gabrielle, Allio, Gael, Fouldrin, Valérie, Drouin, Jacqueline, Bou, Michel, Petit, Dominique, Campion, Thierry, Frébourg   +13 more
openaire   +2 more sources

Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities

Frontiers in Plant Science, 2020
Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton, Cécile Cabassa-Hourton, Arnould Savouré, Dietmar Funck, Giuseppe Forlani   +4 more
doaj   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid-Driven Gluconeogenesis through Histone Crotonylation. [PDF]

Adv Sci (Weinh)
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Sheng C, Li T, Lin H, Ma X, Zhou F, Li M, Wang Y, Wang S, Tan J, Chen J, Yang Y, Liu J, Bi Y, Lu J, Wang X, Zhou L.   +15 more
europepmc   +2 more sources

Respiratory electron transfer pathways in plant mitochondria [PDF]

, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Braun, Hans-Peter, Schertl, Peter
core   +10 more sources

Physiological characterization of drought stress response and expression of two transcription factors and two LEA genes in three Prunus genotypes [PDF]

, 2016
Global warming has led to a progressive decrease in rainfall, which is reflected by a reduction of water resources in the soil and a negative effect on crop production in Mediterranean areas.
Bielsa Pérez, Beatriz, Leida, Carmen, Rubio Cabetas, Mª Jose   +2 more
core   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle. [PDF]

Psychiatry Clin Neurosci
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Wang T, Trabzonlu K, Jones EF, Syed YA.
europepmc   +2 more sources