Results 21 to 30 of about 2,833 (174)

Hyperprolinemia type I caused by homozygous p.T466M mutation in PRODH [PDF]

Human Genome Variation, 2021
Hyperprolinemia type I (HPI) is an autosomal recessive metabolic disorder caused by defects in proline oxidase. We herein describe a case of a patient with HPI and harboring the NM_016335.4 (PRODH_v001):c.1397 C > T (p.T466M) mutation and polymorphisms ...
Rina Hama, Jun Kido, Keishin Sugawara, Toshiro Nakamura, Kimitoshi Nakamura   +4 more
doaj   +3 more sources

Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line

International Journal of Molecular Sciences, 2022
The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells.
Ilona Zaręba, Weronika Baszanowska, Thi Yen Ly Huynh   +2 more
exaly   +2 more sources

SlgA, the homologue of the human schizophrenia associated PRODH gene, acts in clock neurons to regulate Drosophila aggression [PDF]

Disease Models & Mechanisms, 2017
Mutations in proline dehydrogenase (PRODH) are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear.
Vulsteke, Veerle, Buhl, Edgar, Veerle Vulsteke, Zwarts, Liesbeth, Liesbeth Zwarts, Edgar Buhl, Hodge, James J.L., Callaerts, Patrick, James J. L. Hodge, Patrick Callaerts, Hodge, James J L   +10 more
core   +3 more sources

Functional Consequences of PRODH Missense Mutations [PDF]

The American Journal of Human Genetics, 2005
PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation pathway. At least 16
Hu, Chien-An, Valle, David, Bender, Hans-Ulrich, Pulver, Ann, Almashanu, Shlomo, Steel, Gary, Willis, Alecia, Lin, Wei-Wen   +7 more
core   +3 more sources

Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis [PDF]

BMC Plant Biology, 2014
Background:Proline (Pro) dehydrogenase (ProDH) potentiates the oxidative burst and cell death of the plantHypersensitive Response (HR) by mechanisms not yet elucidated.
Hajirezaei, Mohammad Reza, Monteoliva, Mariela Inés, Rizzi, Yanina, Cecchini, Nicolas Miguel, Alvarez, Maria Elena   +4 more
core   +5 more sources

Troglitazone-Induced PRODH/POX-Dependent Apoptosis Occurs in the Absence of Estradiol or ERβ in ER-Negative Breast Cancer Cells

Journal of Clinical Medicine, 2021
The impact of estradiol on troglitazone (TGZ)-induced proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied in wild-type and PRODH/POX-silenced estrogen receptor (ER) dependent MCF-7 cells and ER-independent MDA-MB-231 cells ...
Ilona Zaręba, Thi Yen Ly Huynh, Izabela Prokop   +2 more
exaly   +2 more sources

Brief research communication: PRODH gene is associated with executive function in schizophrenic families

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2008
The aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first-episode schizophrenic families who had ...
Liu, X, Murray, RM, Toulopoulou, T, Xiehe Liu, Wang, Y C, Murray, R M, Collier, DA, Xiaohong Ma, Collier, D A, Meng, H, Ma, X, Ma, X H, Tao Li, Robin M. Murray, Yan, C, Wang, Y, Timothea Toulopoulou, Yingcheng Wang, Meng, H Q, Xun Hu, Huaqing Meng, Yan, C Y, Hu, X, Li, T, Chengying Yan, David A. Collier, Liu, X H   +26 more
core   +6 more sources

Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004
Haploinsufficiency for or mutation in at least one gene from the velocardiofacial syndrome (VCFS) region at chromosome 22q11 is implicated in psychosis.
Liu, X, Murray, RM, Xiehe Liu, Pak C. Sham, Murray, R M, Collier, DA, Xiaohong Ma, Collier, D A, Meng, H, Xueli Sun, Ma, X, Wang, Q, Tao Li, Sham, P C, Qiang Wang, Robin M. Murray, Sham, PC, Xun Hu, Huaqing Meng, Wei Deng, Deng, W, Hu, X, Li, T, Sun, X, David A. Collier   +24 more
core   +5 more sources

Proline dehydrogenase (PRODH) is a differentially expressed gene in brain metastatic human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans ...
Shahan Mamoor
core   +3 more sources

Disruption of the Prolidase–Proline–PRODH Axis and Oxidative Stress in Schizophrenia

Van Tıp Dergisi
INTRODUCTION: This study aimed to investigate serum levels of proline, prolidase, proline dehydrogenase (PRODH), and reactive oxygen species (ROS) in patients with schizophrenia and healthy controls, to evaluate potential differences between groups and ...
Mehmet Güneş, Burhan Çoban, Betül Uyar, Mehmet Cemal Kaya, Nuriye Mete, Mahmut Bulut   +5 more
doaj   +2 more sources