Results 21 to 30 of about 2,971 (153)

In silico Analysis of PRODH Mutations and their biological significance in disease etiology

Abasyn Journal Life Sciences, 2022
In the present study, we performed in silico analysis on all reported mutations of PRODH in order to investigate their biological significance. 3D models of wildtype and mutant PRODH were predicted using I-TASSER.
Abida Bibi, Iftikhar Ahmed, Syed Shakil Abbas, Muzammal, Muhammad, Sumra Wajid Abbasi, Sana Fatima, Shahzadi Raheela Anum, Ansar Ahmad Abbasi, Muzammil Ahmad Khan   +8 more
core   +3 more sources

Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility

Schizophrenia Research, 2006
Synergistic interaction between genes on chromosome 22q11 recently has been proposed as a possible mechanism which could confer increased risk for schizophrenia.
Williams, Hywel, Glaser, Beate, Kirov, George, Escott-Price, Valentina, Murphy, Kieran C., O'Donovan, Michael Conlon, Williams Melville, Nigel, Owen, Michael John, Murphy, Kieran C, Owen, Michael J, Moskvina, Valentina, Williams, Nigel, O'Donovan, Michael C   +12 more
core   +5 more sources

Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy [PDF]

, 2018
Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane protein linked to electron transport and capable of generating mitochondrial glutamate and intracellular ATP, especially under cellular stress conditions.
Becker, Beatrice
core   +3 more sources

Association of 757 C/T polymorphismin PRODH gene with Schizophrenia in Iranian population [PDF]

Archives of Advances in Biosciences, 2013
Evidence is emerging for the association of polymorphisms in PRODH gene and increased risk of schizophrenia. In this project, peripheral blood sampling was obtained from 175 schizophrenia patients that their diseases were confirmed by psychiatrists.
Rahman zadeh, Saeid, Heidari keshel, Saeed, Omidinia, Eskandar, Ghasemvand, Fariba, Salehi, Zivar, Fakour, Yousef   +5 more
core   +2 more sources

Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

Psychiatric Genetics, 2006
Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies.
Collier, D A, Munro, J, Sinclair, M, Osborne, S, Breen, G; id_orcid, Clair, D S, Li, T, Kerwin, R, Prata, Diana   +8 more
core   +4 more sources

Hyperprolinemia type I caused by homozygous p.T466M mutation in PRODH [PDF]

Human Genome Variation, 2021
AbstractHyperprolinemia type I (HPI) is an autosomal recessive metabolic disorder caused by defects in proline oxidase. We herein describe a case of a patient with HPI and harboring the NM_016335.4 (PRODH_v001):c.1397 C > T (p.T466M) mutation and polymorphisms in thePRODHgene, as detected by plasma amino acid analysis and Sanger sequencing.
Rina Hama, Jun Kido, Keishin Sugawara, Toshiro Nakamura, Kimitoshi Nakamura   +4 more
openaire   +3 more sources

Functional Consequences of PRODH Missense Mutations [PDF]

The American Journal of Human Genetics, 2005
PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation pathway. At least 16 PRODH missense mutations have been identified in studies of type I hyperprolinemia (HPI) and ...
Bender, Hans-Ulrich, Almashanu, Shlomo, Steel, Gary, Hu, Chien-An, Lin, Wei-Wen, Willis, Alecia, Pulver, Ann, Valle, David   +7 more
openaire   +2 more sources

PRODH mutations and hyperprolinemia in a subset of schizophrenic patients [PDF]

Human Molecular Genetics, 2002
The increased prevalence of schizophrenia among patients with the 22q11 interstitial deletion associated with DiGeorge syndrome has suggested the existence of a susceptibility gene for schizophrenia within the DiGeorge syndrome chromosomal region (DGCR) on 22q11.
Hélène, Jacquet, Grégory, Raux, Florence, Thibaut, Bernadette, Hecketsweiler, Emmanuelle, Houy, Caroline, Demilly, Sadeq, Haouzir, Gabrielle, Allio, Gael, Fouldrin, Valérie, Drouin, Jacqueline, Bou, Michel, Petit, Dominique, Campion, Thierry, Frébourg   +13 more
openaire   +2 more sources

In Silico Structural Modeling of Wildtype and Mutant PRODH Proteins Involved in Psychiatric Disorder. [PDF]

Proceedings of the National Academy of Sciences, 2021
Abstract Proline dehydrogenase is an important mitochondrial enzyme that is encoded by the PRODH gene. Biologically, a mutation in this gene affects the activity of proline dehydrogenase enzyme that is normally involved in conversion of proline to glutamate.
Muhammad Muzammal, Sumra Wajid Abbasi, Ansar Ahmad Abbasi, Muzammil Ahmad Khan   +3 more
openaire   +4 more sources

Identification of PRODH as a mitochondria- and angiogenesis-related biomarker for lung adenocarcinoma

Translational Cancer Research, 2023
Abstract Background: The mitochondria and their associated genes were highly related to cellular metabolism. It plays a vital role in the therapy tumors. Angiogenesis is a critical process in the development and progression of tumors, including lung adenocarcinoma. Tumor growth and metastasis are dependent on angiogenesis. This study identified
Xi, Xinran, Zhang, Meng, Li, Yonghua, Wang, Xianghai   +3 more
openaire   +2 more sources