Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population [PDF]
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004 AbstractHaploinsufficiency for or mutation in at least one gene from the velocardiofacial syndrome (VCFS) region at chromosome 22q11 is implicated in psychosis. Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of
Collier, DA +10 more
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Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia [PDF]
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2003 AbstractPeople with deletion of the chromosome 22q11 region associated with velo cardio‐facial syndrome (VCFS) have a remarkably high risk of developing schizophrenia. Recently, the gene proline dehydrogenase (PRODH) which maps to 22q11 and is also an excellent functional candidate gene for psychosis, has been reported to show genetic association with ...
Williams, H.J. +7 more
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Proline dehydrogenase (PRODH) is a differentially expressed gene in brain metastatic human breast cancer. [PDF]
, 2021 Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
Shahan Mamoor
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Hyperprolinemia type I caused by homozygous p.T466M mutation in PRODH [PDF]
Human Genome Variation, 2021 Hyperprolinemia type I (HPI) is an autosomal recessive metabolic disorder caused by defects in proline oxidase. We herein describe a case of a patient with HPI and harboring the NM_016335.4 (PRODH_v001):c.1397 C > T (p.T466M) mutation and polymorphisms ...
Rina Hama +4 more
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In silico Analysis of PRODH Mutations and their biological significance in disease etiology [PDF]
Abasyn Journal Life Sciences, 2022 In the present study, we performed in silico analysis on all reported mutations of PRODH in order to investigate their biological significance. 3D models of wildtype and mutant PRODH were predicted using I-TASSER. Protein-protein docking was done with Cluspro, while protein-substrate docking was done with Auto Dock tools.
Muhammad Muzammal +8 more
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Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes [PDF]
Psychiatric Genetics, 2006 Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play
Prata, Diana +8 more
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Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Ilona Zareba +6 more
doaj +5 more sources
The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD [PDF]
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016 The proline dehydrogenase (PRODH) gene maps to 22q11.2 in the region deleted in the velo‐cardio‐facial syndrome (VCFS). A moderate to severe reduction (>50%) in PRODH activity resulting from recessive deletions and/or missense mutations has been shown to cause type 1 hyperprolinemia (HPI).
Richard, Anne-Claire +11 more
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Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy [PDF]
, 2019 Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane protein linked to electron transport and capable of generating mitochondrial glutamate and intracellular ATP, especially under cellular stress conditions.
Becker, Beatrice
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Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility [PDF]
Schizophrenia Research, 2006 Synergistic interaction between genes on chromosome 22q11 recently has been proposed as a possible mechanism which could confer increased risk for schizophrenia. Based on this hypothesis, our study aimed to explore main, cis- and trans-interacting effects of three candidate genes on 22q11, ProDH, COMT and ZDHHC8. We selected four putative risk variants,
Glaser, Beate +7 more
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