Results 41 to 50 of about 2,833 (174)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism. [PDF]

Adv Sci (Weinh)
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Ying H, Fan H, Wang Y, Jiang R, Cai D, Cheng H, Wang H, Jiang C, Liang P.   +8 more
europepmc   +2 more sources

In Silico Structural Modeling of Wildtype and Mutant PRODH Proteins Involved in Psychiatric Disorder. [PDF]

Proceedings of the National Academy of Sciences, 2021
Abstract Proline dehydrogenase is an important mitochondrial enzyme that is encoded by the PRODH gene. Biologically, a mutation in this gene affects the activity of proline dehydrogenase enzyme that is normally involved in conversion of proline to glutamate.
Muhammad Muzammal, Sumra Wajid Abbasi, Ansar Ahmad Abbasi, Muzammil Ahmad Khan   +3 more
openaire   +4 more sources

Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. [PDF]

PLoS ONE, 2013
Proline dehydrogenase (Prodh) and Δ(1)-pyrroline-5-carboxylate dehydrogenase (P5Cdh) are two key enzymes in the cellular biogenesis of glutamate.
Ziting Yao, Chengwu Zou, Hui Zhou, Jinzi Wang, Lidan Lu, Yang Li, Baoshan Chen   +6 more
doaj   +1 more source

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase. [PDF]

Molecules
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Meeks KR, Bogner AN, Nix JC, Tanner JJ.
europepmc   +2 more sources

Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion. [PDF]

Cancer Med
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Yajima S, Tsukada Y, Yamashita R, Fujisawa T, Kuwata T, Watanabe R, Ishii G, Gabelia N, Juhl H, Koga Y, Yoshino T, Ito M, Masuda H.   +12 more
europepmc   +2 more sources

Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities

Frontiers in Plant Science, 2020
Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton, Cécile Cabassa-Hourton, Arnould Savouré, Dietmar Funck, Giuseppe Forlani   +4 more
doaj   +1 more source

Arabidopsis Proline Dehydrogenase Contributes to Flagellin-Mediated PAMP-Triggered Immunity by Affecting RBOHD

Molecular Plant-Microbe Interactions, 2016
Plants activate different defense systems to counteract the attack of microbial pathogens. Among them, the recognition of conserved microbial- or pathogen-associated molecular patterns (MAMPs or PAMPs) by pattern-recognition receptors stimulates MAMP- or
Georgina Fabro, Yanina Soledad Rizzi, María Elena Alvarez   +2 more
doaj   +1 more source

Genetic variations in amino acid metabolism-related genes are associated with risk of papillary thyroid carcinoma: a case-control study. [PDF]

BMC Endocr Disord
Background Abnormal amino acid metabolic pathways, especially those of glutamine, serine and proline, are crucial to tumourigenesis and the development of papillary thyroid carcinoma (PTC).
Meng H, Xiao Z, Wang Q, Li D, Li Z.
europepmc   +2 more sources

Hepatic CBP/p300 Orchestrate Amino Acid-Driven Gluconeogenesis through Histone Crotonylation. [PDF]

Adv Sci (Weinh)
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Sheng C, Li T, Lin H, Ma X, Zhou F, Li M, Wang Y, Wang S, Tan J, Chen J, Yang Y, Liu J, Bi Y, Lu J, Wang X, Zhou L.   +15 more
europepmc   +2 more sources

Beneficial Effect of Proline Supplementation on Goat Spermatozoa Quality during Cryopreservation

Animals, 2022
Sperm cryopreservation contributes to the extensive utilization of artificial insemination (AI) in the daily livestock industry. However, due to the presence of few sperm with good biological function in post-thaw goat sperm, its use has been limited for
Weijing Zhang, Lingjiang Min, Yajing Li, Yaning Lang, S. A. Masudul Hoque, Adedeji Olufemi Adetunji, Zhendong Zhu   +6 more
doaj   +1 more source