Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion. [PDF]
Cancer MedA hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Yajima S +12 more
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Nonsteroidal Anti-Inflammatory Drugs as PPARγ Agonists Can Induce PRODH/POX-Dependent Apoptosis in Breast Cancer Cells: New Alternative Pathway in NSAID-Induced Apoptosis [PDF]
, 2022 Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered to be therapeutics in cancer prevention because of their inhibitory effect on cyclooxygenases (COX), which are frequently overexpressed in many types of cancer.
Arkadiusz Surazynski +3 more
core +1 more source
Beneficial Effect of Proline Supplementation on Goat Spermatozoa Quality during Cryopreservation
Animals, 2022 Sperm cryopreservation contributes to the extensive utilization of artificial insemination (AI) in the daily livestock industry. However, due to the presence of few sperm with good biological function in post-thaw goat sperm, its use has been limited for
Weijing Zhang +6 more
doaj +1 more source
Molecular Plant-Microbe Interactions, 2004 Accumulation of free L-proline (Pro) is a typical stress response incited by osmotic injuries in plants and microorganisms. Although the protective role of Pro in osmotic stress is not well understood, it is thought to function as compatible osmolyte or ...
Georgina Fabro +4 more
doaj +1 more source
Mycorrhizal-mediated lower proline accumulation in Poncirus trifoliata under water deficit derives from the integration of inhibition of proline synthesis with increase of proline degradation. [PDF]
PLoS ONE, 2013 Proline accumulation was often correlated with drought tolerance of plants infected by arbuscular mycorrhizal fungi (AMF), whereas lower proline in some AM plants including citrus was also found under drought stress and the relevant mechanisms have not ...
Ying-Ning Zou +4 more
doaj +1 more source
iScience, 2023 Summary: Epigenetic alterations are especially important in necrotizing enterocolitis (NEC). Here, we reported that histone deacetylase 8 (HDAC8) plays a previously unknown role in modulating arginine metabolism via acetylation of histone 3 lysine 9 ...
Ting Guo +9 more
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Impact of hypovirus infection on the morphology of Δprodh and Δp5cdh and on the accumulation of Prodh and P5Cdh transcripts in the wild-type strain. [PDF]
, 2013 A, Morphology of hypovirus-infected Δprodh and Δp5cdh mutants. The strains were cultured on PDA for 7 days; hypovirus was introduced into Δprodh and Δp5cdh from the hypovirus-infected strain EP713 by anastomosis.
Hui Zhou (13228) +6 more
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Production of Recombinant Proline Dehydrogenase Enzyme from Pseudomonas fluorescens pf-5 in E. coli System [PDF]
Journal of Sciences, Islamic Republic of Iran, 2011 Proline dehydrogenase (ProDH; 1.5.99.8) belongs to superfamily of amino acid dehydrogenase, which plays a significant role in the metabolic pathway from proline to glutamate. The goal of this research was gene cloning and characterization of ProDH enzyme
E. Omidinia
doaj
Beilstein Journal of Nanotechnology, 2010 A glassy carbon electrode (GC) was modified by multi-walled carbon nanotubes (MWCNTs). The modified electrode showed a pair of redox peaks that resulted from the oxygen-containing functional groups on the nanotube surface.
Haitao Zheng +7 more
doaj +1 more source
Identification of PRODH as a mitochondria- and angiogenesis-related biomarker for lung adenocarcinoma. [PDF]
Transl Cancer Res, 2023 Abstract Background: The mitochondria and their associated genes were highly related to cellular metabolism. It plays a vital role in the therapy tumors. Angiogenesis is a critical process in the development and progression of tumors, including lung adenocarcinoma. Tumor growth and metastasis are dependent on angiogenesis. This study identified
Xi X, Zhang M, Li Y, Wang X.
europepmc +3 more sources