Results 41 to 50 of about 2,971 (153)

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

Leaf penetration by endophytic Metarhizium brunneum enables infection of Phthorimaea absoluta in tomato mines while inducing the crop defense system

Pest Management Science, Volume 82, Issue 8, Page 7794-7808, August 2026.
Spraying Metarhizium brunneum on tomato plants controls heterogeneous and upcoming Phthorimaea absoluta populations by infecting larvae within mines and priming plant induced systemic defences. Abstract BACKGROUND The endophytic entomopathogenic fungus Metarhizium brunneum Petch EAMa 01/58‐Su shows strong potential for managing Phthorimaea absoluta, a ...
Esther Aguilera Cuenca, María José García del Rosal, Fabián García Espinoza, Enrique Quesada Moraga, Irene Magdalena Rodríguez Gómez, Meelad Yousef Yousef   +5 more
wiley   +1 more source

Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3133-3152, August 2026.
This review highlights the roles of G‐protein signaling in crop yield and quality, as well as abiotic and biotic stress responses. It also discusses the feasibility of breaking the trade‐off between plant growth and stress tolerance via dissecting G‐protein regulatory pathways, gene editing, mining natural elite variants, and AI‐assisted breeding ...
Haoran Li, Zhilong Zhang, Fangyuan Liu, Haonan Wang, Zebiao He, Sanyuan Tang, Xiaojing Dong, Peng Xie   +7 more
wiley   +1 more source

A Water‐Saving Drought Survival Phenotype in a Wheat TILLING Mutant Involves Survival‐Biased Metabolic and Phosphorylation Reprogramming

Plant, Cell &Environment, Volume 49, Issue 8, Page 5435-5449, August 2026.
ABSTRACT Drought tolerance in crops often involves trade‐offs between water conservation, growth and reproduction. Understanding how water‐saving strategies are implemented at physiological and metabolic levels remains critical for improving crop performance under water‐limited conditions.
Ryosuke Mega, Shun‐ichiro Hirata, Kota Yamashita, Hinano Takase, Taishi Umezawa, Yasuko Watanabe, June‐Sik Kim, Tomoyuki Kosaka, Akihiro Nieda, Hisashi Tsujimoto   +9 more
wiley   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Seasonal shifts in mitochondrial and reactive oxygen species metabolism are linked to ultrastructural remodelling in honey bees (Apis mellifera)

The Journal of Physiology, Volume 604, Issue 12, Page 4745-4770, 15 June 2026.
Abstract figure legend Seasonal changes profoundly reshape honey bee mitochondrial metabolism. In winter, bees shift from complex I (CI)‐ to mitochondrial glycerol‐3‐phosphate dehydrogenase (mG3PDH)‐ and complex II (CII)‐linked respiration. Despite lower CI‐linked respiration ATP production is maintained, suggesting increased energetic efficiency in ...
Adèle Léger, Mélanie Aminot, Samuel Robichaud, Sarah Jorissen, Étienne Hébert‐Chatelain, Nicolas Pichaud   +5 more
wiley   +1 more source

The Association of V427M Missense Mutation of the PRODH Gene with Schizophrenia in the Iranian Patients

Journal of Human Genetics and Genomics, 2018
Background: PRODH is one of the genes that exists in 22q11.2 location and encodes the prolin oxidase enzyme (POX) in the mitochondrial inner membrane and is expressed in the liver, kidney and brain. The importance of the accompaniment of the PRODH gene’s polymorphisms and mutations in increasing the risk of getting afflicted with schizophrenia has been
Seyedeh Sara Karimian, Mohammad Taghi Akbari   +1 more
openaire   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 719-728, May 2026.
ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular mediators linking obesity‐induced inflammation to muscle wasting have remained unclear.
An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa   +4 more
wiley   +1 more source