Results 31 to 40 of about 2,833 (174)

Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy

open access: yes, 2018
Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane protein linked to electron transport and capable of generating mitochondrial glutamate and intracellular ATP, especially under cellular stress conditions.
Becker, Beatrice
core   +2 more sources

Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

open access: yesPsychiatric Genetics, 2006
Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies.
Collier, D A   +8 more
core   +4 more sources

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

open access: yesFrontiers in Pharmacology, 2018
Propolis evokes several therapeutic properties, including anticancer activity. These activities are attributed to the action of polyphenols. Previously it has been demonstrated, that one of the most abundant polyphenolic compounds in ethanolic extracts ...
Ilona Zaręba   +6 more
core   +2 more sources

Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility

open access: yesSchizophrenia Research, 2006
Synergistic interaction between genes on chromosome 22q11 recently has been proposed as a possible mechanism which could confer increased risk for schizophrenia.
Williams, Hywel   +7 more
core   +5 more sources

A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population

open access: yesPsychiatry Research, 2007
Previous studies have suggested that catechol-O-methyltransferase (COMT), proline dehydrogenase (PRODH), and brain-derived neurotrophic factor (BDNF) genes are possible susceptibility genes for schizophrenia.
Xiehe Liu, David A Collier, Tao Li
exaly   +2 more sources

Association of 757 C/T polymorphismin PRODH gene with Schizophrenia in Iranian population

open access: yesArchives of Advances in Biosciences, 2013
Evidence is emerging for the association of polymorphisms in PRODH gene and increased risk of schizophrenia. In this project, peripheral blood sampling was obtained from 175 schizophrenia patients that their diseases were confirmed by psychiatrists.
Rahman zadeh, Saeid   +5 more
core   +2 more sources

Investigation of genetic association between PRODH gene and schizophrenia in Iranian population

open access: yesArchives of Advances in Biosciences, 2012
Schizophrenia is a complicated, debilitative mental disorder. Evidence is emerging for the association of polymorphisms in PRODH gene and increased risk of schizophrenia.
Rahman zadeh, Saeid   +3 more
core   +2 more sources

Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy?

open access: yesFrontiers in Oncology, 2023
Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Xiangyuan Xu   +10 more
doaj   +1 more source

Mexican Patients With Suspected 22q11.2 Deletion Syndrome: Clinical Characterization and Molecular Findings by Fluorescence In Situ Hybridization and Multiplex Ligation-Dependent Probe Amplification. [PDF]

open access: yesMol Genet Genomic Med
Evaluation of 80 Mexican patients with suspected 22q11.2 deletion syndrome, including detailed phenotypic characterization. Multiplex ligation‐dependent probe amplification identified both typical and atypical deletions, underscoring the need for complementary approaches to fluorescence in situ hybridization.
Aguayo-Orozco TA   +7 more
europepmc   +2 more sources

PRODH mutations and hyperprolinemia in a subset of schizophrenic patients [PDF]

open access: yesHuman Molecular Genetics, 2002
The increased prevalence of schizophrenia among patients with the 22q11 interstitial deletion associated with DiGeorge syndrome has suggested the existence of a susceptibility gene for schizophrenia within the DiGeorge syndrome chromosomal region (DGCR) on 22q11.
Hélène, Jacquet   +13 more
openaire   +2 more sources

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