Results 31 to 40 of about 2,971 (153)

Proline dehydrogenase (PRODH) is a differentially expressed gene in brain metastatic human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans ...
Shahan Mamoor
core   +1 more source

Nonsteroidal Anti-Inflammatory Drugs as PPARγ Agonists Can Induce PRODH/POX-Dependent Apoptosis in Breast Cancer Cells: New Alternative Pathway in NSAID-Induced Apoptosis

, 2022
Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered to be therapeutics in cancer prevention because of their inhibitory effect on cyclooxygenases (COX), which are frequently overexpressed in many types of cancer.
Arkadiusz Surazynski, Jerzy Palka, Adam Kazberuk, Magda Chalecka   +3 more
core   +1 more source

PRODH Polymorphisms, Cortical Volumes and Thickness in Schizophrenia

PLoS ONE, 2014
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes.
Vanessa K Ota, Fernanda T Bellucco, Ary Gadelha, Marcos L Santoro, Cristiano Noto, Denise M Christofolini, Idaiane B Assunção, Karen M Yamada, Andrea K Ribeiro-dos-Santos, Sidney Santos, Jair J Mari, Marília A C Smith, Maria I Melaragno, Rodrigo A Bressan, João R Sato, Andrea P Jackowski, Sintia I Belangero   +16 more
openaire   +4 more sources

Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model [PDF]

, 2017
Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (
Arkadiusz Surazynski, Milena Doroszko, Nafis Rahman, Ilona Zareba, Marcin Chrusciel, Jerzy Palka, Wojciech Miltyk   +6 more
core   +2 more sources

Impact of hypovirus infection on the morphology of Δprodh and Δp5cdh and on the accumulation of Prodh and P5Cdh transcripts in the wild-type strain.

, 2013
A, Morphology of hypovirus-infected Δprodh and Δp5cdh mutants. The strains were cultured on PDA for 7 days; hypovirus was introduced into Δprodh and Δp5cdh from the hypovirus-infected strain EP713 by anastomosis.
Hui Zhou (13228), Lidan Lu (456132), Baoshan Chen (41406), Yang Li (7082), Chengwu Zou (456130), Jinzi Wang (456131), Ziting Yao (456129)   +6 more
core   +1 more source

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence [PDF]

The identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and ...
Bruno, Antonino, Raffaella Cinquetti, Cinquetti, Raffaella, Sessa, Fausto, Fausto Sessa, Matteo Gallazzi, Paola Campomenosi, Antonino Bruno, Campomenosi, Paola, Elena Berno, Grossi, Sarah, Chiofalo, Priscilla, La Rosa, Stefano, Maria Teresa Palano, Gallazzi, Matteo, Francesco Acquati, Chiaravalli, Anna Maria, Acquati, Francesco, Priscilla Chiofalo, Stefano La Rosa, Berno, Elena, Palano, Maria Teresa, Anna Maria Chiaravalli, Sarah Grossi   +23 more
core   +1 more source

Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy? [PDF]

, 2023
Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Yijia Chen, Guang Ji, Hanchen Xu, Yujing Liu, Weina Xu, Xiangyuan Xu, Guangtao Zhang   +6 more
core   +1 more source

Iodized Garlic Extract Regulates Stress Responses in Epidermal Keratinocytes via the Transcription Factor Nrf2

Journal of Cosmetic Dermatology, Volume 25, Issue 11, November 2026.
ABSTRACT Objective Garlic exerts protective effects against skin stress, including oxidative damage and trauma. Iodized garlic extract (IGEx) is a cosmetic ingredient developed through iodination of garlic odor components to achieve odor reduction. Although IGEx is expected to exhibit skin stress protection properties similar to garlic, the molecular ...
Yuki Miyauchi, Natsumi Iwasaki, Liangjing Xie, Satoshi Yano, Taichi Hara   +4 more
wiley   +1 more source

Advancing Thermotolerance in Beans: Integrating Physiology, Genomics, and Breeding for Climate Adaptation

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Rising global temperatures increasingly threaten bean production and the food security of millions of people who depend on these protein‐rich legumes. Heat stress during the reproductive stages induces pollen sterility, flower abscission, and disruptions in source–sink relationships, resulting in yield losses of 30%–40% or more when critical ...
Aastha Sharda, Shikha Chaudhary, Bhawna Kumari, Uday C. Jha, Mohar Singh, Inderjit Singh, Kamal Dev Sharma, Kadambot H. M. Siddique, P. V. Vara Prasad, Harsh Nayyar   +9 more
wiley   +1 more source

Integrated Multi‐Omics and Radiogenomic Analysis Identifies S100B and ITGB5 as Complementary Candidate Biomarkers of Glioblastoma Heterogeneity

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrative multi‐omics and radiogenomic framework identifies S100B and ITGB5 as complementary biomarkers of glioblastoma heterogeneity. S100B reflects broad glial–malignant programs, whereas ITGB5 marks focal stromal–vascular, immunoregulatory, and radiomic heterogeneity.
Xuhang Yang, Yusong Zhang, Yutuo Zheng, Jian Lin   +3 more
wiley   +1 more source