Results 51 to 60 of about 663 (113)

Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis

BMC Plant Biology, 2010
Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun, Eckard Sonja, Funck Dietmar   +2 more
doaj   +1 more source

Seasonal shifts in mitochondrial and reactive oxygen species metabolism are linked to ultrastructural remodelling in honey bees (Apis mellifera)

The Journal of Physiology, Volume 604, Issue 12, Page 4745-4770, 15 June 2026.
Abstract figure legend Seasonal changes profoundly reshape honey bee mitochondrial metabolism. In winter, bees shift from complex I (CI)‐ to mitochondrial glycerol‐3‐phosphate dehydrogenase (mG3PDH)‐ and complex II (CII)‐linked respiration. Despite lower CI‐linked respiration ATP production is maintained, suggesting increased energetic efficiency in ...
Adèle Léger, Mélanie Aminot, Samuel Robichaud, Sarah Jorissen, Étienne Hébert‐Chatelain, Nicolas Pichaud   +5 more
wiley   +1 more source

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence [PDF]

The identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and ...
Bruno, Antonino, Raffaella Cinquetti, Cinquetti, Raffaella, Sessa, Fausto, Fausto Sessa, Matteo Gallazzi, Paola Campomenosi, Antonino Bruno, Campomenosi, Paola, Elena Berno, Grossi, Sarah, Chiofalo, Priscilla, La Rosa, Stefano, Maria Teresa Palano, Gallazzi, Matteo, Francesco Acquati, Chiaravalli, Anna Maria, Acquati, Francesco, Priscilla Chiofalo, Stefano La Rosa, Berno, Elena, Palano, Maria Teresa, Anna Maria Chiaravalli, Sarah Grossi   +23 more
core   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

Molecules
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks, Alexandra N. Bogner, Jay C. Nix, John J. Tanner   +3 more
doaj   +1 more source

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 719-728, May 2026.
ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular mediators linking obesity‐induced inflammation to muscle wasting have remained unclear.
An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa   +4 more
wiley   +1 more source

In silico Analysis of PRODH Mutations and their biological significance in disease etiology

, 2022
In the present study, we performed in silico analysis on all reported mutations of PRODH in order to investigate their biological significance. 3D models of wildtype and mutant PRODH were predicted using I-TASSER.
Abida Bibi, Iftikhar Ahmed, Syed Shakil Abbas, Muzammal, Muhammad, Sumra Wajid Abbasi, Sana Fatima, Shahzadi Raheela Anum, Ansar Ahmad Abbasi, Muzammil Ahmad Khan   +8 more
core   +1 more source

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus

Molecules, 2018
Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of ...
Mieke M. E. Huijbers, Ilona van Alen, Jenny W. Wu, Arjan Barendregt, Albert J. R. Heck, Willem J. H. van Berkel   +5 more
doaj   +1 more source

The Role of Histone Modifications in Plant Priming and Their Analysis by Chromatin Immunoprecipitation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Plants are frequently exposed to adverse conditions. Priming, also known as acclimation or hardening, induces stress memory and prepares plants for future challenges by activating defense and protective mechanisms. For this reason, priming is an effective means to maintain plant yield in the face of climate change. Memory behind the priming is
Aslihan Temel, Nihal Gören‐Sağlam
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source