Results 51 to 60 of about 4,962 (199)

Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells

Frontiers in Microbiology, 2018
Under physiological conditions, most human endogenous retroviruses (HERVs) are transcriptionally silent. However, re-activation of HERVs is observed under pathological conditions like inflammation or cancer.
Thomas Mueller, Claudia Hantsch, Ines Volkmer, Martin S. Staege   +3 more
doaj   +1 more source

AtPAN: an integrated system for reconstructing transcriptional regulatory networks in Arabidopsis thaliana [PDF]

, 2012
Background Construction of transcriptional regulatory networks (TRNs) is of priority concern in systems biology. Numerous high-throughput approaches, including microarray and next-generation sequencing, are extensively adopted to examine transcriptional ...
Yi-An Chen, Ying-Chi Wen, Wen-Chi Chang
core   +2 more sources

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular mediators linking obesity‐induced inflammation to muscle wasting have remained unclear.
An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa   +4 more
wiley   +1 more source

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade

Cell Reports, 2016
Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders.
Gregg W. Crabtree, Alan J. Park, Joshua A. Gordon, Joseph A. Gogos   +3 more
doaj   +1 more source

CNVs and Chromosomal Aneuploidy in Patients With Early-Onset Schizophrenia and Bipolar Disorder: Genotype-Phenotype Associations

Frontiers in Psychiatry, 2021
Introduction: Early-onset schizophrenia (EOS) and bipolar disorder (EOB) start before the age of 18 years and have a more severe clinical course, a worse prognosis, and a greater genetic loading compared to the late-onset forms.
Hojka Gregoric Kumperscak, Hojka Gregoric Kumperscak, Danijela Krgovic, Danijela Krgovic, Maja Drobnic Radobuljac, Maja Drobnic Radobuljac, Nina Senica, Andreja Zagorac, Nadja Kokalj Vokac, Nadja Kokalj Vokac   +9 more
doaj   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

Frontiers in Pharmacology, 2018
Propolis evokes several therapeutic properties, including anticancer activity. These activities are attributed to the action of polyphenols. Previously it has been demonstrated, that one of the most abundant polyphenolic compounds in ethanolic extracts ...
Katarzyna Celińska-Janowicz, Ilona Zaręba, Urszula Lazarek, Joanna Teul, Michał Tomczyk, Jerzy Pałka, Wojciech Miltyk   +6 more
doaj   +1 more source

A Water‐Saving Drought Survival Phenotype in a Wheat TILLING Mutant Involves Survival‐Biased Metabolic and Phosphorylation Reprogramming

Plant, Cell &Environment, EarlyView.
ABSTRACT Drought tolerance in crops often involves trade‐offs between water conservation, growth and reproduction. Understanding how water‐saving strategies are implemented at physiological and metabolic levels remains critical for improving crop performance under water‐limited conditions.
Ryosuke Mega, Shun‐ichiro Hirata, Kota Yamashita, Hinano Takase, Taishi Umezawa, Yasuko Watanabe, June‐Sik Kim, Tomoyuki Kosaka, Akihiro Nieda, Hisashi Tsujimoto   +9 more
wiley   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans [PDF]

, 2018
Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity.
KIM, EUN JI, KWON, SUJEONG, Lee, Seung-Jae V.   +2 more
core   +1 more source