Results 51 to 60 of about 2,842 (177)

Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline

Antioxidants, 2022
Mitochondrial complex I can produce large quantities of reactive oxygen species (ROS) by reverse electron transfer (RET) from the ubiquinone (UQ) pool.
Kevin Wang, Jonathan Hirschenson, Amanda Moore, Ryan J. Mailloux   +3 more
doaj   +1 more source

Supplementation of 2-Ap, Zn and La Improves 2-Acetyl-1-Pyrroline Concentrations in Detached Aromatic Rice Panicles In Vitro. [PDF]

PLoS ONE, 2016
Aromatic rice is highly prized by consumers worldwide due to its special aromatic character. 2-acetyl-1-pyrroline (2-AP) is considered to be the single most important volatile compound responsible for aroma in aromatic rice.
Zhaowen Mo, Jinxia Huang, Di Xiao, Umair Ashraf, Meiyang Duan, Shenggang Pan, Hua Tian, Lizhong Xiao, Keyou Zhong, Xiangru Tang   +9 more
doaj   +1 more source

Association of Candidate Single Nucleotide Polymorphisms Related to Candidate Genes in Patients With Schizophrenia

Basic and Clinical Neuroscience, 2020
Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated ...
Seyedeh Sara Karimian, Mohammad Taghi Akbari, Seyed Saeed Sadr, Gholamreza Javadi   +3 more
doaj  

Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells

Frontiers in Microbiology, 2018
Under physiological conditions, most human endogenous retroviruses (HERVs) are transcriptionally silent. However, re-activation of HERVs is observed under pathological conditions like inflammation or cancer.
Thomas Mueller, Claudia Hantsch, Ines Volkmer, Martin S. Staege   +3 more
doaj   +1 more source

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade

Cell Reports, 2016
Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders.
Gregg W. Crabtree, Alan J. Park, Joshua A. Gordon, Joseph A. Gogos   +3 more
doaj   +1 more source

Advancing Thermotolerance in Beans: Integrating Physiology, Genomics, and Breeding for Climate Adaptation

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Rising global temperatures increasingly threaten bean production and the food security of millions of people who depend on these protein‐rich legumes. Heat stress during the reproductive stages induces pollen sterility, flower abscission, and disruptions in source–sink relationships, resulting in yield losses of 30%–40% or more when critical ...
Aastha Sharda, Shikha Chaudhary, Bhawna Kumari, Uday C. Jha, Mohar Singh, Inderjit Singh, Kamal Dev Sharma, Kadambot H. M. Siddique, P. V. Vara Prasad, Harsh Nayyar   +9 more
wiley   +1 more source

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

CNVs and Chromosomal Aneuploidy in Patients With Early-Onset Schizophrenia and Bipolar Disorder: Genotype-Phenotype Associations

Frontiers in Psychiatry, 2021
Introduction: Early-onset schizophrenia (EOS) and bipolar disorder (EOB) start before the age of 18 years and have a more severe clinical course, a worse prognosis, and a greater genetic loading compared to the late-onset forms.
Hojka Gregoric Kumperscak, Hojka Gregoric Kumperscak, Danijela Krgovic, Danijela Krgovic, Maja Drobnic Radobuljac, Maja Drobnic Radobuljac, Nina Senica, Andreja Zagorac, Nadja Kokalj Vokac, Nadja Kokalj Vokac   +9 more
doaj   +1 more source

Leaf penetration by endophytic Metarhizium brunneum enables infection of Phthorimaea absoluta in tomato mines while inducing the crop defense system

Pest Management Science, Volume 82, Issue 8, Page 7794-7808, August 2026.
Spraying Metarhizium brunneum on tomato plants controls heterogeneous and upcoming Phthorimaea absoluta populations by infecting larvae within mines and priming plant induced systemic defences. Abstract BACKGROUND The endophytic entomopathogenic fungus Metarhizium brunneum Petch EAMa 01/58‐Su shows strong potential for managing Phthorimaea absoluta, a ...
Esther Aguilera Cuenca, María José García del Rosal, Fabián García Espinoza, Enrique Quesada Moraga, Irene Magdalena Rodríguez Gómez, Meelad Yousef Yousef   +5 more
wiley   +1 more source

A Water‐Saving Drought Survival Phenotype in a Wheat TILLING Mutant Involves Survival‐Biased Metabolic and Phosphorylation Reprogramming

Plant, Cell &Environment, Volume 49, Issue 8, Page 5435-5449, August 2026.
ABSTRACT Drought tolerance in crops often involves trade‐offs between water conservation, growth and reproduction. Understanding how water‐saving strategies are implemented at physiological and metabolic levels remains critical for improving crop performance under water‐limited conditions.
Ryosuke Mega, Shun‐ichiro Hirata, Kota Yamashita, Hinano Takase, Taishi Umezawa, Yasuko Watanabe, June‐Sik Kim, Tomoyuki Kosaka, Akihiro Nieda, Hisashi Tsujimoto   +9 more
wiley   +1 more source