Results 71 to 80 of about 2,842 (177)

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 719-728, May 2026.
ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular mediators linking obesity‐induced inflammation to muscle wasting have remained unclear.
An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa   +4 more
wiley   +1 more source

The Association of V427M Missense Mutation of the PRODH Gene with Schizophrenia in the Iranian Patients

Journal of Human Genetics and Genomics, 2018
Background: PRODH is one of the genes that exists in 22q11.2 location and encodes the prolin oxidase enzyme (POX) in the mitochondrial inner membrane and is expressed in the liver, kidney and brain. The importance of the accompaniment of the PRODH gene’s polymorphisms and mutations in increasing the risk of getting afflicted with schizophrenia has been
Seyedeh Sara Karimian, Mohammad Taghi Akbari   +1 more
openaire   +1 more source

Diagram of the PRODH gene, representing the variants investigated in this study and their locations. [PDF]

, 2014
Diagram of the PRODH gene, representing the variants investigated in this study and their locations.
Karen M. Yamada (519133), Ândrea K. Ribeiro-dos-Santos (519134), Maria I. Melaragno (519135), Ary Gadelha (291025), Fernanda T. Bellucco (519128), João R. Sato (153911), Denise M. Christofolini (519131), Sintia I. Belangero (519136), Rodrigo A. Bressan (291032), Marília A. C. Smith (5657782), Vanessa K. Ota (519127), Sidney Santos (151965), Idaiane B. Assunção (519132), Andrea P. Jackowski (516576), Marcos L. Santoro (519129), Cristiano Noto (519130), Jair J. Mari (309023)   +16 more
core   +1 more source

PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize

Translational Oncology, 2023
Background: Lung cancer is a serious threat to human life. It is of great significance to elucidate the pathogenesis of lung cancer and search for new markers.
Lihong Zhang, Xinyu Zhao, Enqin Wang, Ye Yang, Liangfeng Hu, Hongkun Xu, Baojun Zhang   +6 more
doaj   +1 more source

The Role of Histone Modifications in Plant Priming and Their Analysis by Chromatin Immunoprecipitation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Plants are frequently exposed to adverse conditions. Priming, also known as acclimation or hardening, induces stress memory and prepares plants for future challenges by activating defense and protective mechanisms. For this reason, priming is an effective means to maintain plant yield in the face of climate change. Memory behind the priming is
Aslihan Temel, Nihal Gören‐Sağlam
wiley   +1 more source

The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene [PDF]

Journal of Medical Genetics, 2003
Since the original reports of hyperprolinaemia by Scriver et al 1 and Shafer et al ,2 two types of this rare metabolic disorder have been biochemically characterised3: type I (MIM 239500) results from the defect of the enzyme proline dehydrogenase (oxidase), which ensures the conversion of proline into Δ-1-pyrroline-5-carboxylate (P5C), the first step ...
H, Jacquet, J, Berthelot, C, Bonnemains, G, Simard, P, Saugier-Veber, G, Raux, D, Campion, D, Bonneau, T, Frebourg   +8 more
openaire   +2 more sources

At least two p53 family members control the expression of PRODH in mammalian cells. [PDF]

, 2013
A. Analysis of PRODH transcript levels after ectopic expression of p53 family members p53, p63β, p73β. Expression constructs for p53, p63β, p73β were transfected in HCT116 p53-/- cells and PRODH transcript induction was assayed by qPCR and compared to ...
Yari Ciribilli (218760), Alberto Inga (53320), Alessandra Bisio (218766), Gilberto Fronza (218781), Paola Campomenosi (431559), Paola Monti (218762), Loredano Pollegioni (431558), Ivan Raimondi (431557)   +7 more
core   +1 more source

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus

Molecules, 2018
Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of ...
Mieke M. E. Huijbers, Ilona van Alen, Jenny W. Wu, Arjan Barendregt, Albert J. R. Heck, Willem J. H. van Berkel   +5 more
doaj   +1 more source

Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes [PDF]

Psychiatric Genetics, 2014
Velocardiofacial (VCFS; 22q11.2 deletion) syndrome is a genetic disorder that results from a hemizygous deletion of the q11.2 region on chromosome 22, and is associated with greatly increased risk for psychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia.
Petya D, Radoeva, Ioana L, Coman, Cynthia A, Salazar, Karen L, Gentile, Anne Marie, Higgins, Frank A, Middleton, Kevin M, Antshel, Wanda, Fremont, Robert J, Shprintzen, Bernice E, Morrow, Wendy R, Kates   +10 more
openaire   +2 more sources

A Novel Subgroup of bZIP Proteins Functions as Transcriptional Activators in Hypoosmolarity-Responsive Expression of the ProDH Gene in Arabidopsis [PDF]

Plant and Cell Physiology, 2004
A 6-bp sequence, ACTCAT, acts as a cis-acting element involved in hypoosmolarity- and proline-responsive expression of an Arabidopsis proline dehydrogenase (ProDH) gene. Search of the database for plant cis-acting elements revealed that the ACTCAT sequence is similar to the GCN4 motif [ATGA(C/G)TCAT] that is recognized by bZIP transcription factors. To
Rie, Satoh, Yasunari, Fujita, Kazuo, Nakashima, Kazuo, Shinozaki, Kazuko, Yamaguchi-Shinozaki   +4 more
openaire   +2 more sources