Results 71 to 80 of about 4,962 (199)

H₂O₂-Responsive Hormonal Status Involves Oxidative Burst Signaling and Proline Metabolism in Rapeseed Leaves

Antioxidants, 2022
Drought alters the level of endogenous reactive oxygen species (ROS) and hormonal status, which are both involved in the regulation of stress responses. To investigate the interplay between ROS and hormones in proline metabolism, rapeseed (Brassica napus
Bok-Rye Lee, Van Hien La, Sang-Hyun Park, Md Al Mamun, Dong-Won Bae, Tae-Hwan Kim   +5 more
doaj   +1 more source

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus

Molecules, 2018
Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of ...
Mieke M. E. Huijbers, Ilona van Alen, Jenny W. Wu, Arjan Barendregt, Albert J. R. Heck, Willem J. H. van Berkel   +5 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, Volume 20, Issue 2, Page 447-463, February 2026.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Investigation of genetic association between PRODH gene and schizophrenia in Iranian population

Archives of Advances in Biosciences, 2012
Schizophrenia is a complicated, debilitative mental disorder. Evidence is emerging for the association of polymorphisms in PRODH gene and increased risk of schizophrenia. In the present research, we investigated relationship between of this gene and schizophrenia disease by means of a gene polymorphism using PCR-RFLP technique.150 persons suffering ...
Rahman zadeh, Saeid, Shahbaz Mohammadi, Hamid, karimipour, Morteza, Heidari keshel, Saeed   +3 more
openaire   +1 more source

The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene [PDF]

Journal of Medical Genetics, 2003
Since the original reports of hyperprolinaemia by Scriver et al 1 and Shafer et al ,2 two types of this rare metabolic disorder have been biochemically characterised3: type I (MIM 239500) results from the defect of the enzyme proline dehydrogenase (oxidase), which ensures the conversion of proline into Δ-1-pyrroline-5-carboxylate (P5C), the first step ...
H, Jacquet, J, Berthelot, C, Bonnemains, G, Simard, P, Saugier-Veber, G, Raux, D, Campion, D, Bonneau, T, Frebourg   +8 more
openaire   +2 more sources

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]

, 2010
Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core   +2 more sources

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Structural and functional studies of proline catabolic enzymes and human aldehyde dehydrogenases [PDF]

Oxidation of amino acids, like proline catabolism, is a central part of energy metabolism. Proline is oxidized to glutamate by two enzymes: proline dehydrogenase (PRODH) and 1-pyrroline-5-carboxylate dehydrogenase (P5CDH).
Luo, Min
core   +1 more source

Regulation of Cell Function and Myeloid‐Derived Suppressor Cell Chemotaxis by hsa_circ_0006466‐miR‐1286‐PDGFRA/B Axis in Triple Negative Breast Cancer

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Circular RNAs (circRNAs) play critical regulatory roles in diverse biological processes of breast cancer. This study aimed to investigate the circRNAs potentially related to immunity in triple‐negative breast cancer (TNBC). Methods We identified the dysregulated circRNAs in breast cancer using Gene Expression Omnibus (GEO) datasets.
Fengqin Gao, Mingkai Gong, Yufeng Cao, Xiaoyi Liu, Jian Cui, Bing Du, Rongrong Dou, Chuankui Wei, Hongming Song, Consuelo Amantini   +9 more
wiley   +1 more source