Results 71 to 80 of about 663 (113)

Application of sucrose modulates the expressions of genes involved in proline and polyamine metabolism in maize seedlings exposed to drought

Biologia Plantarum, 2019
Sucrose, proline, and polyamines are compatible solutes accumulating in plant tissues and increasing cellular osmolarity under environmental stresses. These compatible solutes and hydrogen peroxide can function as signaling molecules in plants. There has
C. Altuntaş, A. Sezgin, M. Demiralay, R. Terzi, A. Sağlam, A. Kadioğlu   +5 more
doaj   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

A Lysine to Alanine Mutant in Escherichia coli PutA Remarkably Reduces Its PRODH Activity

, 2018
The imino acid proline plays a critical function in the oxidative stress response in organisms. The catabolism of proline is catalyzed by two enzymes PRODH and P5CDH, which constitute a single protein known as PutA in gram-negative bacteria.
Thelen, Brandon
core  

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

PLoS Genetics, 2015
Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS).
Ayşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish Dharuri, Najaf Amin, Jan Bert van Klinken, Lennart C Karssen, Boukje de Vries, Axel Meissner, Sibel Göraler, Arn M J M van den Maagdenberg, André M Deelder, Peter A C 't Hoen, Cornelia M van Duijn, Ko Willems van Dijk   +14 more
doaj   +1 more source

The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD.

, 2016
International audienceThe proline dehydrogenase (PRODH) gene maps to 22q11.2 in the region deleted in the velo-cardio-facial syndrome (VCFS). A moderate to severe reduction (>50%) in PRODH activity resulting from recessive deletions and/or missense ...
Betancur, Catalina, Rovelet-Lecrux, Anne, Afenjar, Alexandra, Delaby, Elsa, Dussardier, Brigitte Gilbert, Scherer, Stephen, W, Richard, Anne-Claire, Campion, Dominique, Thiruvahindrapuram, Bhooma, Eis, Peggy, S, Eis, Peggy ,, Scherer, Stephen ,, Hatchwell, Eli, Charbonnier, Camille   +13 more
core   +1 more source

Intracellular Prodh activity of C. parasitica strains in various culture media^a.

, 2013
aProdh activity was expressed as 1 μM of P5C formed per min per 100 mg of mycelium. The data are from three replicates.
Hui Zhou (13228), Lidan Lu (456132), Baoshan Chen (41406), Yang Li (7082), Chengwu Zou (456130), Jinzi Wang (456131), Ziting Yao (456129)   +6 more
core   +1 more source

1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis

Journal for ImmunoTherapy of Cancer, 2018
Background Tumor cell mediated immune-suppression remains a question of interest in tumor biology. In this study, we focused on the metabolites that are released by prostate cancer cells (PCC), which could potentially attenuate T cell immunity.
Yutao Yan, Lei Chang, Hongzhe Tian, Lu Wang, Yawei Zhang, Tao Yang, Guohao Li, Weifeng Hu, Kavita Shah, Gang Chen, Yonglian Guo   +10 more
doaj   +1 more source

At least two p53 family members control the expression of PRODH in mammalian cells.

, 2013
A. Analysis of PRODH transcript levels after ectopic expression of p53 family members p53, p63β, p73β. Expression constructs for p53, p63β, p73β were transfected in HCT116 p53-/- cells and PRODH transcript induction was assayed by qPCR and compared to ...
Yari Ciribilli (218760), Alberto Inga (53320), Alessandra Bisio (218766), Gilberto Fronza (218781), Paola Campomenosi (431559), Paola Monti (218762), Loredano Pollegioni (431558), Ivan Raimondi (431557)   +7 more
core   +1 more source

Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

, 2006
Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies.
Collier, D A, Munro, J, Sinclair, M, Osborne, S, Breen, G; id_orcid, Clair, D S, Li, T, Kerwin, R, Prata, Diana   +8 more
core   +1 more source

Proline Metabolism of Different Varieties of Hami Melon Fruits in Response to Low Temperature [PDF]

Shipin Kexue
In order to investigate the change in proline metabolism of two varieties of Hami melon fruits during low-temperature storage, ‘Xizhoumi 25’ and ‘Gashi’ melons were pre-cooled for 24 h and then placed for up to 42 days in a mechanical cold storage at (3 ...
BI Ying, WANG Xinyu, LI Hui, HUANG Shuai, ZHANG Qi, LEI Yaxin, WANG Xue, WANG Fuxin, XU Wenchang, WANG Jing
doaj   +1 more source