System-based proteomic and metabonomic analysis of the Df(16)A+/- mouse identifies potential miR-185 targets and molecular pathway alterations [PDF]
, 2017 Deletions on chromosome 22q11.2 are a strong genetic risk factor for development of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography-mass spectrometry (LC-MS) proteomic and metabonomic profiling approaches on prefrontal ...
Bahn, S. (Sabine) +7 more
core +2 more sources
Emerging Roles of De Novo Proline Biosynthesis in Human Diseases
FASEB BioAdvances, Volume 7, Issue 11, November 2025.De novo proline synthesis, a multi‐step biochemical pathway starting from glutamate, supplies essential protein building blocks. It supports redox balance, cell proliferation, signal transduction, and nucleotide and protein biosynthesis. This tightly regulated pathway, governed by conserved mechanisms, is disrupted in diseases such as cancer and ...
Ethan Pei, Junfeng Ma
wiley +1 more source
, 2021 Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
openaire +2 more sources
Hyperprolinemia as a clue in the diagnosis of a patient with a psychiatric disorder [PDF]
, 2016 Background: Over the last few years, microdeletions of the 22q11.2 region responsible for DiGeorge syndrome, or velocardiofacial syndrome, have been increasingly related to neuropsychiatric disorders including schizophrenia and bipolar disorders.
Antunes, D. +6 more
core
Drought tolerance and antioxidant enzymatic activity in transgenic ?Swingle? citrumelo plants over-accumulating proline. [PDF]
, 2011 In this study we investigated the effects of the high endogenous proline level on water relations, gas exchange and antioxidant enzymatic activity in leaves of transgenic ?Swingle?
BESPALHOK FILHO, J. C. +6 more
core +1 more source
Notas sobre la coyuntura nacional: una mirada desde los derechos humanos [PDF]
, 2009 La agudización de la crisis económica, los límites y obstáculos de la participación democrática son los temas principales de este análisis que busca acercar una visión completa de la realidad y ofrecer elementos en aras de construir una comprensión de la
Arriaga, Luis
core
Potential Consequences of Intra-Regional Trade in Short-Term Food Security Crises in Southeastern Africa [PDF]
A report prepared by Michigan State University for the World Bank under contract No. 7144132, Strengthening Food Security in Sub-Saharan Africa through Trade Liberalization and Regional IntegrationAfrica, trade, emergency, Food Security and Poverty ...
Dorosh, Paul A. +3 more
core +1 more source
Violencia en México: enfoques desde los derechos humanos [PDF]
, 2011 Este escrito muestra un panorama general de la violencia que se ha desatado en México y la urgencia de medidas integrales para responder, cabalmente, a una grave problemática social.ITESO, A ...
Arriaga, Luis
core
Two patients with chromosome 22q11.2 deletion presenting with childhood obesity and hyperphagia [PDF]
, 2016 Chromosome 22q11.2 deletion syndrome is a clinically heterogeneous condition of intellectual disability, parathyroid and thyroid hypoplasia, palatal abnormalities, cardiac malformations and psychiatric symptoms.
Bassett, John +2 more
core +1 more source
Journal for ImmunoTherapy of Cancer, 2018 Background Tumor cell mediated immune-suppression remains a question of interest in tumor biology. In this study, we focused on the metabolites that are released by prostate cancer cells (PCC), which could potentially attenuate T cell immunity.
Yutao Yan +10 more
doaj +1 more source