Results 81 to 90 of about 2,842 (177)

Phylogenetic trees of Prodh and P5Cdh across kingdoms. [PDF]

, 2013
The phylogenetic trees were generated from amino acid sequences using the Neighbor-joining, minimum-evolution, and maximum-parsimony methods in the MEGA4.0 software. The sequence alignment data were bootstrapped with 1,000 resamplings.
Hui Zhou (13228), Lidan Lu (456132), Baoshan Chen (41406), Yang Li (7082), Chengwu Zou (456130), Jinzi Wang (456131), Ziting Yao (456129)   +6 more
core   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. [PDF]

, 2004
Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) may both be susceptibility genes for schizophrenia. As part of the evaluation of their roles in psychosis, we used reverse transcription-polymerase chain reaction to measure COMT and ...
Burnet, PW, Harrison, PJ, Burnet, Philip, Sodhi, MS, Tunbridge, E, Harrison, Paul   +5 more
core   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Novel alternative splicing of the PRODH locus. [PDF]

, 2013
A. Exons (green boxes) and introns (yellow lines) of the PRODH locus are shown. A 100 bp shaded box covers part of intron 13, intron14 and exon 14 and part of exon 15. Two sSNPs are illustrated by vertical blue hash marks. B.
Andrew D. Farmer (147049), Irina Khrebtukova (156652), Shujun Luo (121977), Gregory D. May (145918), Stanton Martin (376070), Neil A. Miller (360386), Faye D. Schilkey (140258), Ray J. Langley (376061), Ryan W. Kim (376063), Selene M. Virk (376057), Richard Harlan (376067), Sat Kirpal Khalsa (376064), Russell D. Wolfinger (138415), Jim J. Huntley (376055), Sharon Lewis (376056), Joann Mudge (140254), Jennifer C. van Velkinburgh (104166), Victoria Ambriz-Griffith (376066), Stephen F. Kingsmore (104189), Ingrid E. Lindquist (277218), John P. Utsey (376062), Wendy Czika (138413), M. Kathy Myers (376059), Nora I. Perrone-Bizzozero (285942), Meredith Garcia (376065), William D. Beavis (6129), Rosalinda C. Roberts (367518), Lu Zhang (50563), C. Forrest Black (376058), Lar C. Mader (376060), Gary P. Schroth (156674)   +30 more
core   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, Volume 80, Issue 3, Page 166-179, March 2026.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Drought-induced responses of organic osmolytes and proline metabolism during pre-flowering stage in leaves of peanut (Arachis hypogaea L.)

Journal of Integrative Agriculture, 2017
: Peanut (Arachis hypogaea L.), an improtant oil crop, usually encounters drought stress in the process of growth and development, especially at pre-flowering stage.
Ming ZHANG, Li-feng WANG, Kun ZHANG, Feng-zhen LIU, Yong-shan WAN   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, Volume 20, Issue 2, Page 447-463, February 2026.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source