Results 61 to 70 of about 2,842 (177)

Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline

Molecules, 2017
Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick, Travis A. Pemberton, Benjamin W. Arentson, Donald F. Becker, John J. Tanner   +4 more
doaj   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

A Lysine to Alanine Mutant in Escherichia coli PutA Remarkably Reduces Its PRODH Activity [PDF]

, 2018
The imino acid proline plays a critical function in the oxidative stress response in organisms. The catabolism of proline is catalyzed by two enzymes PRODH and P5CDH, which constitute a single protein known as PutA in gram-negative bacteria.
Thelen, Brandon
core  

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence [PDF]

The identification of markers for early diagnosis, prognosis, and improvement of therapeutic options represents an unmet clinical need to increase survival in Non-Small Cell Lung Cancer (NSCLC), a neoplasm still characterized by very high incidence and ...
Bruno, Antonino, Raffaella Cinquetti, Cinquetti, Raffaella, Sessa, Fausto, Fausto Sessa, Matteo Gallazzi, Paola Campomenosi, Antonino Bruno, Campomenosi, Paola, Elena Berno, Grossi, Sarah, Chiofalo, Priscilla, La Rosa, Stefano, Maria Teresa Palano, Gallazzi, Matteo, Francesco Acquati, Chiaravalli, Anna Maria, Acquati, Francesco, Priscilla Chiofalo, Stefano La Rosa, Berno, Elena, Palano, Maria Teresa, Anna Maria Chiaravalli, Sarah Grossi   +23 more
core   +1 more source

Seasonal shifts in mitochondrial and reactive oxygen species metabolism are linked to ultrastructural remodelling in honey bees (Apis mellifera)

The Journal of Physiology, Volume 604, Issue 12, Page 4745-4770, 15 June 2026.
Abstract figure legend Seasonal changes profoundly reshape honey bee mitochondrial metabolism. In winter, bees shift from complex I (CI)‐ to mitochondrial glycerol‐3‐phosphate dehydrogenase (mG3PDH)‐ and complex II (CII)‐linked respiration. Despite lower CI‐linked respiration ATP production is maintained, suggesting increased energetic efficiency in ...
Adèle Léger, Mélanie Aminot, Samuel Robichaud, Sarah Jorissen, Étienne Hébert‐Chatelain, Nicolas Pichaud   +5 more
wiley   +1 more source

Intracellular Prodh activity of C. parasitica strains in various culture media^a. [PDF]

, 2013
aProdh activity was expressed as 1 μM of P5C formed per min per 100 mg of mycelium. The data are from three replicates.
Hui Zhou (13228), Lidan Lu (456132), Baoshan Chen (41406), Yang Li (7082), Chengwu Zou (456130), Jinzi Wang (456131), Ziting Yao (456129)   +6 more
core   +1 more source

Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis

BMC Plant Biology, 2010
Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun, Eckard Sonja, Funck Dietmar   +2 more
doaj   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Screening and characterization of proline dehydrogenase flavoenzyme producing Pseudomonas entomophila

Iranian Journal of Microbiology, 2011
Background and Objectives: Proline dehydrogenase (ProDH; 1.5.99.8) plays an important role in specific determination of plasma proline level in biosensor and diagnostic kits.
H Shahbaz- Mohammadi, E Omidinia
doaj