Results 61 to 70 of about 663 (113)

Hepatic‐Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi‐Omics Analysis of Tumors With Lymphovascular Invasion

Cancer Medicine, Volume 15, Issue 4, April 2026.
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Shugo Yajima, Yuichiro Tsukada, Riu Yamashita, Takao Fujisawa, Takeshi Kuwata, Reiko Watanabe, Genichiro Ishii, Nina Gabelia, Hartmut Juhl, Yoshikatsu Koga, Takayuki Yoshino, Masaaki Ito, Hitoshi Masuda   +12 more
wiley   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Association of 757 C/T polymorphismin PRODH gene with Schizophrenia in Iranian population [PDF]

, 2013
Evidence is emerging for the association of polymorphisms in PRODH gene and increased risk of schizophrenia. In this project, peripheral blood sampling was obtained from 175 schizophrenia patients that their diseases were confirmed by psychiatrists.
Rahman zadeh, Saeid, Heidari keshel, Saeed, Omidinia, Eskandar, Ghasemvand, Fariba, Salehi, Zivar, Fakour, Yousef   +5 more
core   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia

, 2003
People with deletion of the chromosome 22q11 region associated with velo cardio-facial syndrome (VCFS) have a remarkably high risk of developing schizophrenia.
N. Williams, N. Norton, H.J. Williams, Norton, N., Williams, Nigel Melville, Spurlock, G., M.J. Owen, M.C. O'Donovan, Kirov, George, Williams, H.J., Zammit, Stanley, G. Spurlock, O'Donovan, Michael Conlon, S. Zammit, G. Kirov, Owen, Michael John   +15 more
core   +1 more source

Disruption of the Prolidase–Proline–PRODH Axis and Oxidative Stress in Schizophrenia

Van Tıp Dergisi
INTRODUCTION: This study aimed to investigate serum levels of proline, prolidase, proline dehydrogenase (PRODH), and reactive oxygen species (ROS) in patients with schizophrenia and healthy controls, to evaluate potential differences between groups and ...
Mehmet Güneş, Burhan Çoban, Betül Uyar, Mehmet Cemal Kaya, Nuriye Mete, Mahmut Bulut   +5 more
doaj   +1 more source

Drought-induced responses of organic osmolytes and proline metabolism during pre-flowering stage in leaves of peanut (Arachis hypogaea L.)

Journal of Integrative Agriculture, 2017
: Peanut (Arachis hypogaea L.), an improtant oil crop, usually encounters drought stress in the process of growth and development, especially at pre-flowering stage.
Ming ZHANG, Li-feng WANG, Kun ZHANG, Feng-zhen LIU, Yong-shan WAN   +4 more
doaj   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, Volume 80, Issue 3, Page 166-179, March 2026.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation.

, 2008
Type I hyperprolinemia (HPI) is an autosomal recessive disorder caused by proline oxidase deficiency. This enzyme is encoded by the proline dehydrogenase (PRODH) gene on 22q11.
SGRO DL, TORTORELLA, Gaetano, SPANO M, PUSTORINO GIUSEPPIN, OLIVIA, CACCAMO, Daniela, AGUENNOUZ, M'hammed, CALABRÒ M, CAMPION D, LEGALLIC S, BONSIGNORE M, DI ROSA, GABRIELLA   +10 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, Volume 20, Issue 2, Page 447-463, February 2026.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source