Capturing Transitional Pluripotency through Proline Metabolism [PDF]
Cells, 2022 In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti +4 more
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Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism [PDF]
Cell Death Discovery, 2023 The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how cells adapt their metabolic activity to ...
Jiahao He +3 more
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Arbuscular mycorrhizal fungi enhanced rice proline metabolism under low temperature with nitric oxide involvement [PDF]
Frontiers in Plant Science, 2022 Arbuscular mycorrhizal fungi (AMF) are known to improve plant stress tolerance by regulating proline accumulation, and nitric oxide (NO) plays an important signaling role in proline metabolism.
Zhilei Liu +9 more
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Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus) [PDF]
Journal of Animal Science and BiotechnologyBackground Saline-alkaline water aquaculture has become a key way to mitigate the reduction of freshwater aquaculture space and meet the increasing global demand for aquatic products. To enhance the comprehensive utilization capability of saline-alkaline
Minxu Wang +6 more
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Dysregulated Proline Metabolism Exacerbates Hepatocellular Carcinoma Metastasis via EPRS1-Mediated mRNA Translation [PDF]
Cancer CommunicationsBackground: Metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC), and amino acid reprogramming plays an important role in its metastatic progression.
Hui Zhang +12 more
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Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress [PDF]
Cell Death and Disease, 2023 Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui +18 more
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Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells. [PDF]
PLoS ONE, 2022 Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are three
Saif Sattar Alaqbi +17 more
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Connecting proline metabolism and signaling pathways in plant senescence
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu eZhang, Donald eBecker
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Proline dehydrogenase, a rate-limiting catabolic enzyme, affecting the growth and pathogenicity of Toxoplasma gondii tachyzoites by regulating the proline metabolism and mitochondrial function of the parasite [PDF]
Parasites & VectorsBackground The pathogenicity of Toxoplasma gondii is closely associated with its intracellular lytic cycle in host cells. Currently, the mechanisms by which T. gondii completes the lytic cycle remain unclear.
Xiao-Ling Geng +9 more
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Hydrogen Sulfide Treatment Alleviates Chilling Injury in Cucumber Fruit by Regulating Antioxidant Capacity, Energy Metabolism and Proline Metabolism [PDF]
Foods, 2022 Although low-temperature storage could maintain the quality of fruits and vegetables, it may also result in chilling injury (CI) in cold-sensitive produce, such as cucumbers.
Jingda Wang +4 more
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