Capturing Transitional Pluripotency through Proline Metabolism [PDF]
Cells, 2022 In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti +4 more
doaj +5 more sources
Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism [PDF]
Cell Death Discovery, 2023 The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how cells adapt their metabolic activity to ...
Jiahao He +3 more
doaj +3 more sources
Proline metabolism and transport in plant development [PDF]
Amino Acids, 2010 Proline fulfils diverse functions in plants. As amino acid it is a structural component of proteins, but it also plays a role as compatible solute under environmental stress conditions.
Dietmar Funck +2 more
exaly +6 more sources
Connecting proline metabolism and signaling pathways in plant senescence
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu eZhang, Donald eBecker
doaj +5 more sources
Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle [PDF]
CellsHepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Natalia F. Zakirova +17 more
doaj +4 more sources
Targeting the glutamine-arginine-proline metabolism axis in cancer [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryMetabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism.
Jiang-Jie Duan +2 more
exaly +4 more sources
Proline Metabolism in WHO G4 Gliomas Is Altered as Compared to Unaffected Brain Tissue [PDF]
CancersProline metabolism has been identified as a significant player in several neoplasms, but knowledge of its role in gliomas is limited despite it providing a promising line of pursuit. Data on proline metabolism in the brain are somewhat historical.
Karol Sawicki +2 more
exaly +3 more sources
The Janus-like role of proline metabolism in cancer. [PDF]
Cell Death Discov, 2020 The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread.
Burke L +6 more
europepmc +6 more sources
Microbiota alterations in proline metabolism impact depression [PDF]
Cell Metabolism, 2022 Aminoàcids; Depressió; MicrobiotaAminoácidos; Depresión; MicrobiotaAmino acids; Depression; MicrobiotaThe microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy.
Jordi Mayneris-Perxachs +2 more
exaly +4 more sources
Arbuscular mycorrhizal fungi enhanced rice proline metabolism under low temperature with nitric oxide involvement [PDF]
Frontiers in Plant Science, 2022 Arbuscular mycorrhizal fungi (AMF) are known to improve plant stress tolerance by regulating proline accumulation, and nitric oxide (NO) plays an important signaling role in proline metabolism.
Zhilei Liu +9 more
doaj +2 more sources