The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryPyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa ...
Peng Guo +13 more
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Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis [PDF]
Discover Oncology, 2022 CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous cell carcinoma (ESCC) have not been fully elucidated.
Cui-juan Qian +5 more
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Hydrogen Sulfide Treatment Alleviates Chilling Injury in Cucumber Fruit by Regulating Antioxidant Capacity, Energy Metabolism and Proline Metabolism [PDF]
Foods, 2022 Although low-temperature storage could maintain the quality of fruits and vegetables, it may also result in chilling injury (CI) in cold-sensitive produce, such as cucumbers.
Jingda Wang +4 more
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Proline metabolism and transport in retinal health and disease. [PDF]
Amino Acids, 2021 The retina is one of the most energy-demanding tissues in the human body. Photoreceptors in the outer retina rely on nutrient support from the neighboring retinal pigment epithelium (RPE), a monolayer of epithelial cells that separate the retina and choroidal blood supply.
Du J, Zhu S, Lim RR, Chao JR.
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Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells [PDF]
Experimental and Molecular MedicineFerritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels.
Ji Min Park +14 more
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Proline Metabolism in Tumor Growth and Metastatic Progression [PDF]
Frontiers in Oncology, 2020 Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.
Cristina D'Aniello +3 more
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Proline Metabolism in Response to Climate Extremes in Hairgrass. [PDF]
Plants (Basel)Hairgrass (Deschampsia caespitosa), a widely distributed grass species considered promising in the ecological restoration of degraded grassland in the Qinghai-Xizang Plateau, is likely to be subjected to frequent drought and waterlogging stress due to ...
Luo Q +6 more
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Targeting proline metabolism? [PDF]
Nature Reviews Cancer, 2016 Gemma K Alderton, Alderton Gemma K
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Journal of Plant Interactions, 2022 It has been discovered that many plants accumulate proline in response to osmotic stress. However, the interaction between salinity stress and proline metabolism-related genes has not been unequivocally identified in Spartina alterniflora.
Yang Zhao +4 more
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Horticultural Plant Journal, 2022 Proline accumulation has been shown to occur in plants in response to various environmental stresses. Although proline metabolism-related genes have been functionally characterized, the inter-organ transport of proline in stressed plants remains unclear.
Zhongyuan Wang +6 more
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