Proline metabolism as regulatory hub
Trends in Plant Science, 2021 Proline is a multifunctional amino acid that is accumulated in high concentrations in plants under various stress conditions. Proline accumulation is intimately connected to many cellular processes, such as osmotic pressure, energy status, nutrient ...
Savouré, A. +2 more
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Proline Metabolism and Microenvironmental Stress [PDF]
Annual Review of Nutrition, 2010 Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling.
Olga Zabirnyk, James M. Phang, Wei Liu
core +3 more sources
Proline Metabolism in Neurological and Psychiatric Disorders. [PDF]
Mol Cells, 2022 Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric ...
Yao Y, Han W.
europepmc +3 more sources
Dysregulated Proline Metabolism Exacerbates Hepatocellular Carcinoma Metastasis via EPRS1-Mediated mRNA Translation [PDF]
Cancer CommunicationsBackground: Metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC), and amino acid reprogramming plays an important role in its metastatic progression.
Hui Zhang +12 more
doaj +2 more sources
Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus) [PDF]
Journal of Animal Science and BiotechnologyBackground Saline-alkaline water aquaculture has become a key way to mitigate the reduction of freshwater aquaculture space and meet the increasing global demand for aquatic products. To enhance the comprehensive utilization capability of saline-alkaline
Minxu Wang +6 more
doaj +2 more sources
Substrate channeling in proline metabolism [PDF]
Frontiers in Bioscience, 2012 Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may
Becker, Donald F. +2 more
core +3 more sources
Proline Metabolism in Malignant Gliomas: A Systematic Literature Review. [PDF]
Cancers (Basel), 2022 Background: Proline has attracted growing interest because of its diverse influence on tumor metabolism and the discovery of the regulatory mechanisms that appear to be involved.
Sawicka MM +4 more
europepmc +3 more sources
Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress [PDF]
Cell Death and Disease, 2023 Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui +18 more
doaj +2 more sources
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells. [PDF]
PLoS ONE, 2022 Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are three
Saif Sattar Alaqbi +17 more
doaj +2 more sources
Proline dehydrogenase, a rate-limiting catabolic enzyme, affecting the growth and pathogenicity of Toxoplasma gondii tachyzoites by regulating the proline metabolism and mitochondrial function of the parasite [PDF]
Parasites & VectorsBackground The pathogenicity of Toxoplasma gondii is closely associated with its intracellular lytic cycle in host cells. Currently, the mechanisms by which T. gondii completes the lytic cycle remain unclear.
Xiao-Ling Geng +9 more
doaj +2 more sources