Capturing Transitional Pluripotency through Proline Metabolism [PDF]
Cells, 2022 In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti +4 more
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Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism [PDF]
Cell Death Discovery, 2023 The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how cells adapt their metabolic activity to ...
Jiahao He +3 more
doaj +4 more sources
Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis [PDF]
Discover Oncology, 2022 CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous cell carcinoma (ESCC) have not been fully elucidated.
Cui-juan Qian +5 more
doaj +4 more sources
The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryPyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa ...
Peng Guo +13 more
doaj +4 more sources
Proline Metabolism in Tumor Growth and Metastatic Progression [PDF]
Frontiers in Oncology, 2020 Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.
Cristina D'Aniello +3 more
doaj +6 more sources
Proline metabolism in cancer [PDF]
Amino Acids, 2021 Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is the only proteogenic secondary amino acid that is abundant in the body. Recent studies have shown that proline metabolism plays an important role in metabolic reprogramming and affects the occurrence and development of cancer.
Pengyu Geng, Wangshu Qin, Guowang Xu
exaly +6 more sources
Arbuscular mycorrhizal fungi enhanced rice proline metabolism under low temperature with nitric oxide involvement [PDF]
Frontiers in Plant Science, 2022 Arbuscular mycorrhizal fungi (AMF) are known to improve plant stress tolerance by regulating proline accumulation, and nitric oxide (NO) plays an important signaling role in proline metabolism.
Zhilei Liu +9 more
doaj +2 more sources
Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus) [PDF]
Journal of Animal Science and BiotechnologyBackground Saline-alkaline water aquaculture has become a key way to mitigate the reduction of freshwater aquaculture space and meet the increasing global demand for aquatic products. To enhance the comprehensive utilization capability of saline-alkaline
Minxu Wang +6 more
doaj +2 more sources
Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress [PDF]
Cell Death and Disease, 2023 Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui +18 more
doaj +2 more sources
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells. [PDF]
PLoS ONE, 2022 Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are three
Saif Sattar Alaqbi +17 more
doaj +2 more sources