The Janus-like role of proline metabolism in cancer. [PDF]
Cell Death Discov, 2020 The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread.
Burke L +6 more
europepmc +10 more sources
Proline metabolism as regulatory hub
Trends in Plant Science, 2021 Proline is a multifunctional amino acid that is accumulated in high concentrations in plants under various stress conditions. Proline accumulation is intimately connected to many cellular processes, such as osmotic pressure, energy status, nutrient ...
Savoure, Arnould +7 more
core +4 more sources
Proline Metabolism and Microenvironmental Stress [PDF]
Annual Review of Nutrition, 2010 Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling.
Olga Zabirnyk, James M. Phang, Wei Liu
core +3 more sources
Substrate channeling in proline metabolism [PDF]
Frontiers in Bioscience, 2012 Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may
Becker, Donald F. +2 more
core +4 more sources
Proline Metabolism in WHO G4 Gliomas Is Altered as Compared to Unaffected Brain Tissue [PDF]
CancersProline metabolism has been identified as a significant player in several neoplasms, but knowledge of its role in gliomas is limited despite it providing a promising line of pursuit. Data on proline metabolism in the brain are somewhat historical.
Wojciech Miltyk +2 more
exaly +3 more sources
Connecting proline metabolism and signaling pathways in plant senescence [PDF]
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu eZhang, Donald eBecker
doaj +2 more sources
Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle [PDF]
CellsHepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Natalia F. Zakirova +17 more
doaj +2 more sources
Hydrogen Sulfide Treatment Alleviates Chilling Injury in Cucumber Fruit by Regulating Antioxidant Capacity, Energy Metabolism and Proline Metabolism [PDF]
Foods, 2022 Although low-temperature storage could maintain the quality of fruits and vegetables, it may also result in chilling injury (CI) in cold-sensitive produce, such as cucumbers.
Jingda Wang +4 more
doaj +2 more sources
Proline Metabolism in Response to Climate Extremes in Hairgrass. [PDF]
Plants (Basel)Hairgrass (Deschampsia caespitosa), a widely distributed grass species considered promising in the ecological restoration of degraded grassland in the Qinghai-Xizang Plateau, is likely to be subjected to frequent drought and waterlogging stress due to ...
Luo Q +6 more
europepmc +5 more sources
Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells [PDF]
Experimental and Molecular MedicineFerritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels.
Ji Min Park +14 more
doaj +2 more sources