Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle [PDF]
CellsHepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Natalia F. Zakirova +17 more
doaj +5 more sources
The Janus-like role of proline metabolism in cancer. [PDF]
Cell Death Discov, 2020 AbstractThe metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of ...
Burke L +6 more
europepmc +14 more sources
Proline Metabolism in Tumor Growth and Metastatic Progression [PDF]
Frontiers in Oncology, 2020 Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.
Cristina D'Aniello +3 more
doaj +6 more sources
Substrate channeling in proline metabolism [PDF]
Frontiers in Bioscience, 2012 Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism.
Arentson, Benjamin W +2 more
openaire +4 more sources
Proline Metabolism and Microenvironmental Stress [PDF]
Annual Review of Nutrition, 2010 Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling. Collagen in extracellular matrix, connective tissue, and bone is an abundant reservoir for proline.
James M, Phang, Wei, Liu, Olga, Zabirnyk
openaire +3 more sources
Connecting proline metabolism and signaling pathways in plant senescence [PDF]
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu eZhang, Donald eBecker
doaj +2 more sources
Proline Metabolism in WHO G4 Gliomas Is Altered as Compared to Unaffected Brain Tissue [PDF]
CancersProline metabolism has been identified as a significant player in several neoplasms, but knowledge of its role in gliomas is limited despite it providing a promising line of pursuit. Data on proline metabolism in the brain are somewhat historical.
Wojciech Miltyk +2 more
exaly +3 more sources
Plants, 2020 Proline metabolism influences the metabolic and/or signaling pathway in regulating plant stress responses. This study aimed to characterize the physiological significance of glutamate (Glu)-mediated proline metabolism in the drought stress responses ...
Van Hien La +6 more
doaj +2 more sources
Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis [PDF]
Discover Oncology, 2022 CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous cell carcinoma (ESCC) have not been fully elucidated.
Cui-juan Qian +5 more
doaj +2 more sources
Hydrogen Sulfide Treatment Alleviates Chilling Injury in Cucumber Fruit by Regulating Antioxidant Capacity, Energy Metabolism and Proline Metabolism [PDF]
Foods, 2022 Although low-temperature storage could maintain the quality of fruits and vegetables, it may also result in chilling injury (CI) in cold-sensitive produce, such as cucumbers.
Jingda Wang +4 more
doaj +2 more sources