Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis [PDF]
Discover Oncology, 2022 CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous cell carcinoma (ESCC) have not been fully elucidated.
Cui-juan Qian +5 more
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Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle [PDF]
CellsHepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Natalia F. Zakirova +17 more
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The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryPyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa ...
Peng Guo +13 more
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Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells [PDF]
Experimental and Molecular MedicineFerritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels.
Ji Min Park +14 more
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Proline Metabolism in Tumor Growth and Metastatic Progression [PDF]
Frontiers in Oncology, 2020 Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.
Cristina D'Aniello +3 more
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Proline Metabolism in Neurological and Psychiatric Disorders. [PDF]
Mol Cells, 2022 Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric ...
Yao Y, Han W.
europepmc +3 more sources
Targeting the glutamine-arginine-proline metabolism axis in cancer [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryShi-Cang Yu +2 more
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Journal of Plant Interactions, 2022 It has been discovered that many plants accumulate proline in response to osmotic stress. However, the interaction between salinity stress and proline metabolism-related genes has not been unequivocally identified in Spartina alterniflora.
Yang Zhao +4 more
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Horticultural Plant Journal, 2022 Proline accumulation has been shown to occur in plants in response to various environmental stresses. Although proline metabolism-related genes have been functionally characterized, the inter-organ transport of proline in stressed plants remains unclear.
Zhongyuan Wang +6 more
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Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth
Cell Stress, 2020 Proline metabolism is critical for cellular response to microenvironmental stress in living organisms across different kingdoms, ranging from bacteria, plants to animals. In bacteria and plants, proline is known to accrue in response to osmotic and other
Ling Guo, Chuanyue Wu
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