Results 41 to 50 of about 195,829 (321)
Proline Metabolism and Microenvironmental Stress [PDF]
Annual Review of Nutrition, 2010 Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling. Collagen in extracellular matrix, connective tissue, and bone is an abundant reservoir for proline.
James M, Phang, Wei, Liu, Olga, Zabirnyk
openaire +2 more sources
Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism [PDF]
, 2013 Arginase deficiency is a rare autosomal recessive disorder resulting from a loss of the liver arginase isoform, arginase 1 (ARG1), which is the final step in the urea cycle for detoxifying ammonia. ARG1 deficiency leads to hyperargininemia, characterized
Ballantyne, Laurel L. +6 more
core +7 more sources
Substrate channeling in proline metabolism [PDF]
Frontiers in Bioscience, 2012 Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism.
Arentson, Benjamin W +2 more
openaire +2 more sources
Inborn Errors of Proline Metabolism [PDF]
The Journal of Nutrition, 2008 l-Proline concentration is primarily related to the balance of enzymatic activities of proline dehydrogenase [proline oxidase (POX)] and Delta-1-pyrroline-5-carboxylate (P5C) reductase. As a result, P5C plays a pivotal role in maintaining the concentration of proline in body fluids and inborn errors of P5C metabolism lead to disturbance of proline ...
Hiroshi, Mitsubuchi +3 more
openaire +2 more sources
Frontiers in Plant Science, 2020 Understanding the regulation of proline metabolism necessitates the suppression of two Δ1-pyrroline-5-carboxylate synthetase enzyme (P5CS) genes performed in switchgrass (Panicum virgatum L.).
Cong Guan +8 more
doaj +1 more source
Glutamate, Ornithine, Arginine, Proline, and Polyamine Metabolic Interactions: The Pathway Is Regulated at the Post-Transcriptional Level [PDF]
, 2016 The metabolism of glutamate into ornithine, arginine, proline, and polyamines is a major network of nitrogen-metabolizing pathways in plants, which also produces intermediates like nitric oxide, and γ-aminobutyric acid (GABA) that play critical roles in ...
Boubker eBarchi +7 more
core +8 more sources
Frontiers in Bioscience, 2012 Proline plays a special role in cancer metabolism. Proline oxidase (POX), a.k.a. proline dehydrogenase (PRODH), is among a few genes induced rapidly and robustly by P53, the tumor suppressor. Ectopic expression of POX under control of tet-off promoter initiated mitochondrial apoptosis. The mechanism activated by POX is mediated by its production of ROS.
James M, Phang, Wei, Liu
openaire +3 more sources
Targeting the glutamine-arginine-proline metabolism axis in cancer. [PDF]
J Enzyme Inhib Med ChemWang D +6 more
europepmc +2 more sources
Ametryn removal by Metarhizium brunneum: Biodegradation pathway proposal and metabolic background revealed [PDF]
, 2018 Ametryn is a representative of a class of s-triazine herbicides absorbed by plant roots and leaves and characterized as a photosynthesis inhibitor. It is still in use in some countries in the farming of pineapples, soybean, corn, cotton, sugar cane or ...
Abigail +48 more
core +1 more source
Longevity Regulation by Proline Oxidation in Yeast
Microorganisms, 2021 Proline is a pivotal and multifunctional amino acid that is used not only as a nitrogen source but also as a stress protectant and energy source. Therefore, proline metabolism is known to be important in maintaining cellular homeostasis.
Akira Nishimura +5 more
doaj +1 more source