Longevity Regulation by Proline Oxidation in Yeast
Microorganisms, 2021 Proline is a pivotal and multifunctional amino acid that is used not only as a nitrogen source but also as a stress protectant and energy source. Therefore, proline metabolism is known to be important in maintaining cellular homeostasis.
Akira Nishimura +5 more
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Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporter. [PDF]
PLoS ONE, 2014 Trypanosoma cruzi, the etiological agent of Chagas' disease, has a metabolism largely based on the consumption of glucose and proline. This amino acid is essential for host cells infection and intracellular differentiation.
Melisa Sayé +4 more
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Disruption of fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase [PDF]
, 2013 Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle.
Bastie, Claire C. +6 more
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Proline-dependent regulation of collagen metabolism [PDF]
Cellular and Molecular Life Sciences, 2019 AbstractThis review is focused on recent data on the role of proline (Pro) in collagen biosynthesis and cellular metabolism. It seems obvious that one of the main substrates for collagen biosynthesis Pro is required to form collagen molecule. The question raised in this review is whether the Pro for collagen biosynthesis is synthesized “de novo”, comes
Karna, Ewa +3 more
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Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion [PDF]
, 2023 Proline is a nonessential amino acid, and its metabolism has been implicated in numerous malignancies. Together with a direct role in regulating cancer cells' proliferation and survival, proline metabolism plays active roles in shaping the tumor ...
Sara Zanivan +2 more
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The Metabolism of Proline as Microenvironmental Stress Substrate [PDF]
The Journal of Nutrition, 2008 Proline, a unique proteogenic secondary amino acid, has its own metabolic system with special features. Recent findings defining the regulation of this system led us to propose that proline is a stress substrate in the microenvironment of inflammation and tumorigenesis.
James M, Phang +2 more
openaire +2 more sources
Intestinal proline is a potential anti-allergy factor for allergy diagnosis and therapy
Frontiers in Nutrition, 2022 Allergy has become a public health problem worldwide, but effective diagnostic and therapeutic approaches are limited currently. Amino acids are essential macronutrients that potentially participated in the allergy process. This work aimed to investigate
Jinya Ma +10 more
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Rice, 2020 Background Global warming threatens rice growth and reduces yields. Proline plays important roles in plant abiotic stress tolerance. Previous research demonstrated that engineering proline metabolism-related genes can enhance tolerance to freezing and ...
Mingxin Guo +5 more
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The proline regulatory axis and cancer
Frontiers in Oncology, 2012 Studies in metabolism and cancer have characterized changes in core pathways involving glucose and glutamine, emphasizing the provision of substrates for building cell mass.
James Ming Phang
doaj +1 more source
Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae
Microbial Cell, 2019 In many plants and microorganisms, intracellular proline has a protective role against various stresses, including heat-shock, oxidation and osmolarity. Environmental stresses induce cellular senescence in a variety of eukaryotes.
Yukio Mukai +7 more
doaj +1 more source