Results 41 to 50 of about 1,032,868 (266)
Intestinal proline is a potential anti-allergy factor for allergy diagnosis and therapy
Frontiers in Nutrition, 2022 Allergy has become a public health problem worldwide, but effective diagnostic and therapeutic approaches are limited currently. Amino acids are essential macronutrients that potentially participated in the allergy process. This work aimed to investigate
Jinya Ma +10 more
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Proline metabolism and transport in retinal health and disease. [PDF]
Amino Acids, 2021 The retina is one of the most energy-demanding tissues in the human body. Photoreceptors in the outer retina rely on nutrient support from the neighboring retinal pigment epithelium (RPE), a monolayer of epithelial cells that separate the retina and choroidal blood supply.
Du J, Zhu S, Lim RR, Chao JR.
europepmc +4 more sources
The Metabolism of Proline as Microenvironmental Stress Substrate [PDF]
The Journal of Nutrition, 2008 Proline, a unique proteogenic secondary amino acid, has its own metabolic system with special features. Recent findings defining the regulation of this system led us to propose that proline is a stress substrate in the microenvironment of inflammation and tumorigenesis.
James M, Phang +2 more
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Proline transport and metabolism in Rickettsia prowazekii [PDF]
Journal of Bacteriology, 1984 Purified Rickettsia prowazekii cells were able to transport L-proline. The influx of this amino acid had a Kt of 14 microM and a Vmax of about 64 pmol/min per mg of protein. Proline could not be transported by heat-killed or metabolically poisoned rickettsiae or at 0 degrees C. The uptake of proline was linear for almost 2 h.
H H, Winkler, R M, Daugherty
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Rice, 2020 Background Global warming threatens rice growth and reduces yields. Proline plays important roles in plant abiotic stress tolerance. Previous research demonstrated that engineering proline metabolism-related genes can enhance tolerance to freezing and ...
Mingxin Guo +5 more
doaj +1 more source
The proline regulatory axis and cancer
Frontiers in Oncology, 2012 Studies in metabolism and cancer have characterized changes in core pathways involving glucose and glutamine, emphasizing the provision of substrates for building cell mass.
James Ming Phang
doaj +1 more source
Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism [PDF]
, 2020 Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondrial calcium uniporter (MCU), a multi-protein ...
Muniswamy Madesh +12 more
core +3 more sources
Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae
Microbial Cell, 2019 In many plants and microorganisms, intracellular proline has a protective role against various stresses, including heat-shock, oxidation and osmolarity. Environmental stresses induce cellular senescence in a variety of eukaryotes.
Yukio Mukai +7 more
doaj +1 more source
Proline Metabolism in Response to Climate Extremes in Hairgrass. [PDF]
Plants (Basel)Hairgrass (Deschampsia caespitosa), a widely distributed grass species considered promising in the ecological restoration of degraded grassland in the Qinghai-Xizang Plateau, is likely to be subjected to frequent drought and waterlogging stress due to ongoing climate change, further aggravating the degradation of grassland in this region.
Luo Q +6 more
europepmc +4 more sources
Proline metabolism and cancer [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2015 Proline metabolism impacts a number of regulatory targets in both animals and plants and is especially important in cancer. Glutamine, a related amino acid, is considered second in importance only to glucose as a substrate for tumors. But proline and glutamine are interconvertible and linked in their metabolism.
Phang, James M. +3 more
openaire +2 more sources