Results 51 to 60 of about 1,083,777 (264)
Proline metabolism and cancer [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2015 Proline metabolism impacts a number of regulatory targets in both animals and plants and is especially important in cancer. Glutamine, a related amino acid, is considered second in importance only to glucose as a substrate for tumors. But proline and glutamine are interconvertible and linked in their metabolism.
Phang, James M. +3 more
openaire +2 more sources
Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion [PDF]
, 2023 Proline is a nonessential amino acid, and its metabolism has been implicated in numerous malignancies. Together with a direct role in regulating cancer cells' proliferation and survival, proline metabolism plays active roles in shaping the tumor ...
Sara Zanivan +2 more
core +1 more source
Heliyon, 2019 Background: In response to various environmental stresses, many plant species synthesize L-proline in the cytosol and accumulates in the chloroplasts. L-Proline accumulation in plants is a well-recognized physiological reaction to osmotic stress prompted
Mukesh Meena +7 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 Mangoes often suffer from low temperature-induced chilling injury (CI) during postharvest cold storage. Therefore, advanced techniques are crucial and in high demand to solve the chilling stress of mango fruit for a higher value.
Mariama KEBBEH +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer
Pharmaceuticals, 2021 Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Magdalena Misiura +4 more
doaj +1 more source
The effect of water deficit and excess copper on proline metabolism in Nicotiana benthamiana
, 2012 Fluctuation in proline content is a widespread phenomenon among plants in response to heavy metal stress. To distinguish between the participation of water deficit and copper on changes in proline metabolism, potted plants and floating leaf discs of ...
C. -W. Tan +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Changes in morphology, proline content, and palatability to Helix aspersa, in Plantago lanceolata in response to transplantation and polluted soil [PDF]
, 1992 High concentrations of heavy metals are a cause of stress in plants, many of which respond by accumulating high levels of the amino acid proline. Tolerant and intolerant plants may vary in their response, and this may be reflected in the palatability of ...
Lart, K.M.
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