Results 61 to 70 of about 1,083,777 (264)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Light Control of Salt-Induced Proline Accumulation Is Mediated by ELONGATED HYPOCOTYL 5 in Arabidopsis

Frontiers in Plant Science, 2019
Plants have to adapt their metabolism to constantly changing environmental conditions, among which the availability of light and water is crucial in determining growth and development.
Hajnalka Kovács, Dávid Aleksza, Abu Imran Baba, Anita Hajdu, Anna Mária Király, Laura Zsigmond, Szilvia Z. Tóth, László Kozma-Bognár, László Kozma-Bognár, László Szabados   +9 more
doaj   +1 more source

Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line. [PDF]

PLoS ONE, 2018
L-Proline is a multifunctional amino acid that plays an essential role in primary metabolism and physiological functions. Proline is oxidized to glutamate in the mitochondria and the FAD-containing enzyme proline oxidase (PO) catalyzes the first step in ...
Pamela Cappelletti, Elena Tallarita, Valentina Rabattoni, Paola Campomenosi, Silvia Sacchi, Loredano Pollegioni   +5 more
doaj   +1 more source

Effect of drought stress on yield, proline and chlorophyll contents in three chickpea cultivars [PDF]

, 2010
Drought stress is one of the major abiotic stresses in agriculture worldwide. This study was carried out to investigate the effect of drought stress on proline content, chlorophyll content, photosynthesis and transpiration, stomatal conductance and yield
Siosemardeh, A., Mafakheri, A., Struik, P.C., Bahramnejad, B., Sohrabi, Y.   +4 more
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Effect of the Proline Analogue Baikiain on Proline Metabolism in Salmonella typhimurium [PDF]

Journal of Bacteriology, 1972
A proline analogue, 4,5-dehydro- l -pipecolic acid (baikiain) induces the formation in Salmonella typhimurium of the two enzymes catalyzing the degradation of proline, proline oxidase and Δ 1 -pyrroline-5-carboxylic acid (P5C) dehydrogenase.
S, Dendinger, W J, Brill
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Exploring plant-derived matrices for proline encapsulation to enhance proline-mediated heat stress tolerance

Plant Stress
Proline plays a central role in plant adaptation to abiotic stress, but its exogenous application at high concentrations may disrupt proline metabolism and promote oxidative damage. This study evaluated whether controlled foliar delivery of proline using
Vanessa A. Avendaño, Jimmy Sampedro-Guerrero, Aurelio Gómez-Cadenas, Carolina Clausell-Terol   +3 more
doaj   +1 more source

Preprint: Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

, 2023
Previous virulence screens have indicated potential roles during Streptococcus pneumoniae infection for the one-carbon metabolism pathway component Fhs and proline synthesis mediated by ProABC. To define how these metabolic pathways affect S.
Wall, E., Brown, J.S., Ercoli, G., Guerra-Assunção, J.A., Gordon, S.B., Ramos-Sevillano, E., Heyderman, R., Betts, M., Fernandes, V.E., Ferreira, D.M., Partridge, F.   +10 more
core   +1 more source