Results 61 to 70 of about 104,935 (243)

Proline metabolism-related gene expression in four potato genotypes in response to drought stress

Biologia Plantarum, 2019
Drought severely limits potato yield. The aim of this work was to study a response of plantlets of four potato genotypes to polyethylene glycol (PEG 6000)-induced drought stress in both physiological and molecular levels. The drought-tolerant and drought-
Y. LIU, L. WANG, Y. LI, X. LI, J. ZHANG
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Melatonin Combined with 1-Methylcyclopropene Regulates Proline Metabolism to Alleviate Chilling Injury in Postharvest Hami Melons [PDF]

Shipin Kexue
To investigate the effects of melatonin (MT) in combination with 1-methylcyclopropene (1-MCP) on postharvest proline metabolism and chilling injury in Hami melons, this study included four treatments: control (distilled water immersion + distilled water ...
WANG Xiaobing, JIA Meihui, GAO Zhongchuan, CHEN Haixin, CHEN Xiaojie, ZHANG Zonghao, WENG Wanlin, WANG Yu, WANG Jing
doaj   +1 more source

The Multifaceted Roles of Proline in Cell Behavior

Frontiers in Cell and Developmental Biology, 2021
Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary ...
Eduardo J. Patriarca, Federica Cermola, Cristina D’Aniello, Annalisa Fico, Ombretta Guardiola, Dario De Cesare, Gabriella Minchiotti   +6 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Emerging Roles of De Novo Proline Biosynthesis in Human Diseases

FASEB BioAdvances
De novo proline synthesis is a highly conserved and essential biochemical pathway in mammals. Beyond serving as a fundamental building block for proteins, proline also plays key roles in diverse cellular functions and maintaining tissue homeostasis. Over
Ethan Pei, Junfeng Ma
doaj   +1 more source

Humic Acid Alleviates Low-Temperature Stress by Regulating Nitrogen Metabolism and Proline Synthesis in Melon (Cucumis melo L.) Seedlings

Horticulturae
Melon is a thermophilic crop that is extremely sensitive to temperature changes. Humic acid (HA) is an eco-friendly biostimulant that enhances plants against abiotic stresses.
Libao Zhu, Haihe Liu, Yanping Zhang, Yanxia Cao, Yiwen Hu, Yalun Wang, Haiqiang Zheng, Mengze Liu   +7 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source