Results 71 to 80 of about 1,083,777 (264)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Proline metabolism in health and disease [PDF]

Amino Acids, 2008
Traditionally, proline is categorized as one of the nones­ sential amino acids in mammals, however, proline is indispensable in the neonatal small intestine. In addition, proline has features of an inhibitory neuromodulator and a metabolic precursor for glutamate in glutamatergic synapses in the central nervous system.
Chien-An A, Hu, James M, Phang, David, Valle   +2 more
openaire   +2 more sources

Schematic representation of the proline metabolism pathway and the proline cycle.

, 2022
A) Most of the metabolism of proline is localized in the mitochondrion, although the PYCR3 enzyme is localized in the cytoplasm. The main precursors of proline are glutamine/glutamate and ornithine.
Rajinder Singh (246689), Jennifer A. Higgins (7641458), Lynsey Burke (12055056), Alessandro Rufini (3873532), Raquel Palacios-Gallego (12055065), Constantinos Alexandrou (7705007), Cristina Tufarelli (643585), Robert G. Britton (7596356), Saif Sattar Alaqbi (12055053), Caleb Green (12055062), Ni Ni Moe Myint (7787714), Inna Guterman (12055059), Lynne M. Howells (7583441), Donald J. L. Jones (7584767), Anne Thomas (90885), Kevin West (1353297), Hong Cai (166815), Emma Parrott (10646312)   +17 more
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Influence of Proline Deficiency on Enzymes of Proline Metabolism in the Chick

Poultry Science, 1973
Abstract Experiments were conducted to determine the effect of dietary proline on the activity of enzymes of proline metabolism. The omission of proline from the diet for young chicks was without effect on kidney arginase, proline oxidase, Δ1-pyrroline-5-carboxylic acid dehydrogenase; and kidney and liver ornithine-δ-transaminase and Δ1-pyrroline-5 ...
openaire   +2 more sources

Proline Metabolism and Its Functions in Development and Stress Tolerance

, 2019
Proline takes an exceptional place among the proteinogenic amino acids by its specific accumulation in pollen and in response to multiple types of stress.
Trovato, Maurizio, Maurizio Trovato, Dietmar Funck, Signorelli, Santiago, Giuseppe Forlani, Forlani, Giuseppe, Funck, Dietmar, Santiago Signorelli   +7 more
core   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

Proline metabolism-related gene expression in four potato genotypes in response to drought stress

Biologia Plantarum, 2019
Drought severely limits potato yield. The aim of this work was to study a response of plantlets of four potato genotypes to polyethylene glycol (PEG 6000)-induced drought stress in both physiological and molecular levels. The drought-tolerant and drought-
Y. LIU, L. WANG, Y. LI, X. LI, J. ZHANG
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source