Results 91 to 100 of about 1,083,777 (264)

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Quantitative analysis of excreted end-products from proline metabolism in PCFs.

, 2017
Quantitative analysis of excreted end-products from proline metabolism in PCFs.
Nicholas Ejeh (3689863), Michael J. Lehane (197355), Brian S. Mantilla (3689872), Ariel M. Silber (267024), Aitor Casas-Sánchez (3689866), Marc Biran (499609), Frédéric Bringaud (77209), Alvaro Acosta-Serrano (213459), Letícia Marchese (3689869), Naomi A. Dyer (210856)   +9 more
core   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

Nature Communications, 2020
Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in
Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran, Chuanyue Wu   +9 more
doaj   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt

Advanced Science, EarlyView.
A natural microbial consortium employing a cross‐feeding strategy forms a stratified biofilm that promotes endophytic colonization of auxotrophic Flavobacterium. This enhanced colonization activates plant systemic resistance, effectively suppressing Fusarium wilt.
Xianfeng Ye, Changsheng Xu, Shuai Yao, Jiming Shen, Zeyuan Li, Yu Zhang, Fan Wu, Xinjie Li, Yanling Ji, Lei Zhang, Yan Huang, Zhoukun Li, Huayu Qin, Zhongli Cui   +13 more
wiley   +1 more source

Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans‐4‐hydroxy‐L‐proline

, 2021
Aldehyde dehydrogenase 4A1 (ALDH4A1) catalyzes the final steps of both proline and hydroxyproline catabolism. It is a dual substrate enzyme that catalyzes the NAD(+)‐dependent oxidations of L‐glutamate‐γ‐semialdehyde to L‐glutamate (proline metabolism ...
John J. Tanner, McKay, Cole M., Becker, Donald F., Bogner, Alexandra N., Cole M. McKay, Stiers, Kyle M., Donald F. Becker, Alexandra N. Bogner, Kyle M. Stiers, Tanner, John J.   +9 more
core   +1 more source

Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins

Advanced Science, EarlyView.
A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li, Junjie Qiu, Fan Lü, Hua Zhang, Pinjing He   +4 more
wiley   +1 more source

Glucose and Proline Metabolism in Nautilus [PDF]

, 1982
The rates of incorporation of [U-14C]proline and [U-14C]glucose into CO2 and glycogen were assessed in Nautilus pompilius under both in vitro and in vivo conditions. Both substrates exhibited tissue-specific rates of metabolism.
Hochachka, P.W., Fields, JHA
core   +1 more source

Osmolytes: Proline metabolism in plants as sensors of abiotic stress [PDF]

, 2017
Proline accumulation occurs in a large range of plant species in retaliation to the numerous abiotic stresses. An exclusive research pattern suggests there is a pragmatic relation between proline accumulation and plant stress tolerance.
Manoj Kumar Sharma, R. S. Sengar, Sengar, R. S., Singh, Ashu, Sharma, Manoj Kumar, Ashu Singh   +5 more
core   +1 more source