Results 111 to 120 of about 1,032,868 (266)

Proline Metabolism of Different Varieties of Hami Melon Fruits in Response to Low Temperature [PDF]

Shipin Kexue
In order to investigate the change in proline metabolism of two varieties of Hami melon fruits during low-temperature storage, ‘Xizhoumi 25’ and ‘Gashi’ melons were pre-cooled for 24 h and then placed for up to 42 days in a mechanical cold storage at (3 ...
BI Ying, WANG Xinyu, LI Hui, HUANG Shuai, ZHANG Qi, LEI Yaxin, WANG Xue, WANG Fuxin, XU Wenchang, WANG Jing
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Process optimization for enhancing production of cis-4-hydroxy-l-proline by engineered Escherichia coli

Microbial Cell Factories, 2017
Background Understanding the bioprocess limitations is critical for the efficient design of biocatalysts to facilitate process feasibility and improve process economics.
Kequan Chen, Yang Pang, Bowen Zhang, Jiao Feng, Sheng Xu, Xin Wang, Pingkai Ouyang   +6 more
doaj   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Proline Metabolism and Its Functions in Development and Stress Tolerance

, 2019
Proline takes an exceptional place among the proteinogenic amino acids by its specific accumulation in pollen and in response to multiple types of stress.
Trovato, Maurizio, Maurizio Trovato, Dietmar Funck, Signorelli, Santiago, Giuseppe Forlani, Forlani, Giuseppe, Funck, Dietmar, Santiago Signorelli   +7 more
core   +1 more source

Understanding proline metabolism in hypoxic cancer cells [PDF]

, 2023
To survive, cancer cells adapt their metabolism to sustain increased biomass production and bioenergetic demand as well as modulation of redox homeostasis.
Vettore, Lisa
core   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Cancer stem cells synthesize proline to attenuate oxidative stress

The Journal of Clinical Investigation
Cancers reprogram their metabolism to provide anabolic needs without driving excessive oxidative stress. Attention has focused on glucose metabolism, yet amino acid synthesis and degradation also promote tumor cell states and growth.
Weichi Wu, Po Zhang, Donghai Wang, Xujia Wu, Qiulian Wu, Daqi Li, Tengfei Huang, Rui Wang, Huan Li, Hailong Mi, Suchet Taori, Fanen Yuan, Tingting Duan, Zhiye Chen, Huairui Yuan, Jeremy N. Rich   +15 more
doaj   +1 more source

Mechanisms by which proline reductase of Clostridioides difficile promotes efficient metabolism and disease progression in vivo

mBio
Clostridioides difficile is a toxin-producing pathogen that opportunistically infects those with a depleted gut microbiome, often triggered by antibiotic use. C.
Laura M. Cersosimo, Madeline Graham, Auriane Monestier, Aidan Pavao, Jay N. Worley, Johann Peltier, Bruno Dupuy, Lynn Bry   +7 more
doaj   +1 more source