Results 131 to 140 of about 104,935 (243)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism. [PDF]

Adv Sci (Weinh)
Ying H, Fan H, Wang Y, Jiang R, Cai D, Cheng H, Wang H, Jiang C, Liang P.   +8 more
europepmc   +1 more source

A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids

Chemistry – A European Journal, EarlyView.
This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci, Federica Plavi, Giovanni Viscardi, Chad N. Ungarean, Massimo Boiocchi, Christophe Salome, Quentin Lefebvre, Thomas C. Fessard, David Sarlah   +8 more
wiley   +1 more source

Proline metabolism and redox; maintaining a balance in health and disease. [PDF]

Amino Acids, 2021
Vettore LA, Westbrook RL, Tennant DA.
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Proline Metabolism in Cancer: Emerging Roles in Redox Homeostasis and Therapeutic Opportunities. [PDF]

Cancers (Basel)
Rossman TC, Purohit G, Daudu OI, Becker DF.   +3 more
europepmc   +1 more source

High atmospheric pressure rescues plant growth under humidity stress: A model for climate‐resilient deep underground agriculture

Deep Underground Science and Engineering, EarlyView.
High atmospheric pressure (120 kPa) in deep underground counteracts humidity‐induced physiological stress in plants, stabilizing water balance and enhancing antioxidative defenses. This synergy boosts biomass despite elevated humidity, demonstrating sustainable deep underground agriculture potential under climate uncertainty.
Yuxin He, Linglu Xu, Xiao Tan, Wenhua Zhuang, Naiwen Li, Chao Liu, Bo Tan   +6 more
wiley   +1 more source

P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver disease. [PDF]

Life Metab
Lyu Z, Yu S, Peng C, Wu W, Yang W, Ma H, Sun Y, Jing L, Gu H, Tang E, Zhang X, Jiang H, Jiang H, Li J.   +13 more
europepmc   +1 more source

Exogenous Proline Improves Salt Tolerance of Alfalfa through Modulation of Antioxidant Capacity, Ion Homeostasis, and Proline Metabolism. [PDF]

Plants (Basel), 2022
Guo S, Ma X, Cai W, Wang Y, Gao X, Fu B, Li S.   +6 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source