Results 1 to 10 of about 1,975 (157)

Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis

Frontiers in Oncology, 2022
BackgroundProline metabolism is closely related to the occurrence and development of cancer. Δ1-Pyrroline-5-carboxylate reductase (PYCR) is the last enzyme in proline biosynthesis.
Yue Li, Jiahuan Xu, Pengchen Bao, Zhijing Wei, Lei Pan, Jiawei Zhou, Wei Wang   +6 more
doaj   +3 more sources

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

Neoplasia: An International Journal for Oncology Research, 2019
SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported.
Shuaiyi Chen, Xin Yang, Miao Yu, Zhe Wang, Boya Liu, Minghui Liu, Lu Liu, Mengmeng Ren, Hao Qi, Junhua Zou, Ivana Vucenik, Wei-Guo Zhu, Jianyuan Luo   +12 more
doaj   +3 more sources

PYCR1 promotes ovarian cancer progression through HIF-1α signaling

Asian Journal of Surgery
Jiaqi Zong, Xia'nan Yang, Dandan Zhao, Dongmei Fan   +3 more
doaj   +3 more sources

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Nature Metabolism, 2022
Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated fibroblasts (CAFs) and a central driver of cancer aggressiveness.
Emily J. Kay, K. Paterson, Carla Riero-Domingo, D. Sumpton, J. H. M. Däbritz, S. Tardito, Claudia Boldrini, J. Hernandez-Fernaud, D. Athineos, Sandeep Dhayade, E. Stepanova, Enio Gjerga, L. Neilson, S. Lilla, A. Hedley, Grigorios Koulouras, G. McGregor, Craig Jamieson, Radia M. Johnson, Morag Park, K. Kirschner, Crispin J. Miller, Jurre J. Kamphorst, Fabricio Loayza-Puch, J. Saez-Rodriguez, M. Mazzone, K. Blyth, M. Zagnoni, S. Zanivan   +28 more
semanticscholar   +1 more source

Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Murphy Roths Large (MRL) mice possess outstanding capacity to regenerate several tissues. In the present study, we investigated whether this regenerative potential could be associated with the intrinsic particularities possessed by their mesenchymal stem
Gautier Tejedor, Rafael Contreras-Lopez, Audrey Barthelaix, Maxime Ruiz, Danièle Noël, Danièle Noël, Frédéric De Ceuninck, Philippe Pastoureau, Patricia Luz-Crawford, Christian Jorgensen, Christian Jorgensen, Farida Djouad   +11 more
doaj   +1 more source

Proline is increased in allergic asthma and promotes airway remodeling

JCI Insight, 2023
Proline and its synthesis enzyme pyrroline-5-carboxylate reductase 1 (PYCR1) are implicated in epithelial-mesenchymal transition (EMT), yet how proline and PYCR1 function in allergic asthmatic airway remodeling via EMT has not yet been addressed to our ...
Tingting Xu, Zhenzhen Wu, Qi Yuan, Xijie Zhang, Yanan Liu, Chaojie Wu, Meijuan Song, Jingjing Wu, Jingxian Jiang, Zhengxia Wang, Zhongqi Chen, Mingshun Zhang, Mao Huang, Ningfei Ji   +13 more
doaj   +1 more source

Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis

Journal of Experimental & Clinical Cancer Research, 2022
Background Multiple myeloma (MM) remains an incurable cancer despite advances in therapy. Therefore, the search for new targets is still essential to uncover potential treatment strategies.
Inge Oudaert, Hatice Satilmis, Philip Vlummens, Wouter De Brouwer, Anke Maes, Dirk Hose, Elke De Bruyne, Bart Ghesquière, Karin Vanderkerken, Kim De Veirman, Eline Menu   +10 more
doaj   +1 more source

PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer

Journal of Translational Medicine, 2019
Background Liver cancer is the second leading causes of cancer-related death globally. Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a critical role in metabolic profiles of tumors.
Juhua Zhuang, Yanan Song, Ying Ye, Saifei He, Xing Ma, Miao Zhang, Jing Ni, Jiening Wang, Wei Xia   +8 more
doaj   +1 more source

Exosomes from PYCR1 knockdown bone marrow mesenchymal stem inhibits aerobic glycolysis and the growth of bladder cancer cells via regulation of the EGFR/PI3K/AKT pathway

International Journal of Oncology, 2023
Bladder cancer (BC) is a heterogeneous disease, and pyrroline-5-carboxylate reductase 1 (PYCR1) can promote the proliferation and invasion of BC cells and accelerate BC progression.
Zhuohong Li, Ying Jiang, Jian Liu, Hui-Qing Fu, Quan Yang, Wei Song, Yuanwei Li   +6 more
semanticscholar   +1 more source

Expression of pyrroline-5-carpoxylate reductase-1 in colon cancer and its role in tumor cell proliferation, migration and invasion

Di-san junyi daxue xuebao, 2019
Objective To investigate the expression of pyrroline-5-carpoxylate reductase-1 (PYCR1) in colon cancer and the effect of PYCR1 silencing on the proliferation, migration and invasion of colon cancer cells in vitro.
QIN Xi, JIANG Zheng
doaj   +1 more source