Results 11 to 20 of about 1,975 (157)

The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma [PDF]

Cancer Immunology, Immunotherapy
Background Immunotherapy has emerged as an effective treatment for lung adenocarcinoma (LUAD) in recent years. However, the ability of cancer cells to suppress antitumor immune responses through multiple mechanisms has become one of the major challenges ...
Kui Liu, Xiaoyan Yang, Xuemei Tang, Bo Tang   +3 more
exaly   +6 more sources

The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Pyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa ...
Binyu Song
exaly   +7 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism [PDF]

Molecular Oncology
Despite significant advancements, multiple myeloma (MM) remains incurable, largely due to drug resistance. Our previous research has demonstrated that proline metabolism plays a role in MM progression and that inhibiting PYCR1, the final enzyme in ...
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
doaj   +4 more sources

PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification [PDF]

Clinical and Translational Medicine
Background Liver cancer (LC) is among the deadliest cancers worldwide, with existing treatments showing limited efficacy. This study aimed to elucidate the role and underlying mechanisms of pyrroline‐5‐carboxylate reductase 1 (PYCR1) as a potential ...
John Zhong Li
exaly   +4 more sources

Effect and mechanism of PYCR1 on biological function of hepatocellular carcinoma cells under hypoxia [PDF]

Discover Oncology
Background Pyrrole-5-carboxylate reductase 1 (PYCR1) is a key enzyme involved in proline synthesis, which is closely related to the occurrence and development of liver cancer. In this study, we aimed to investigate the relationship and mechanism of PYCR1
Jiayi Guo, Xinxin Jin, Junli Zhang, Yuming Zhang, Wenjuan Wu   +4 more
doaj   +5 more sources

ITPKA phosphorylates PYCR1 and promotes the progression of glioma [PDF]

Heliyon
Glioma is one of the prevalent malignancies, and identifying therapeutic targets for glioma is highly important. Findings of current study revealed that inositol-trisphosphate 3-kinase A (ITPKA) was found abnormally over expressed and thereby exhibited ...
Xiangying Luo, Tao Chen, Junyi Deng, Ziyuan Liu, Changlong Bi, Song Lan   +5 more
doaj   +5 more sources

PYCR1 drives lung cancer progression through functional interactions with EGFR and TLR signaling pathways [PDF]

Experimental and Molecular Medicine
Lung cancer, particularly non-small-cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality worldwide. Recent studies have implicated pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme in proline biosynthesis, in cancer ...
Ji Hye Shin, Ji Young Kim, Mi-Jeong Kim, Yeeun Kang, Ha-Jeong Lee, Bongkum Choi, Ji Su Lee, Dohee Kwon, Seo Hyun Kim, Yoolim Sung, Duk-Hwan Kim, Jae-Hyuck Shim, Eunyoung Chun, Ki-Young Lee   +13 more
doaj   +3 more sources

Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism [PDF]

Cancer Biology & Therapy
Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. This study investigated how PYCR1 promotes BC progression through glycolysis, histone H3 Lysine 18 Lactylation ...
Zhuo Li, Qinghua Jiang, Quan Yang, Yujie Zhou, Jiansong Wang   +4 more
doaj   +3 more sources

PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize

Translational Oncology, 2023
Background: Lung cancer is a serious threat to human life. It is of great significance to elucidate the pathogenesis of lung cancer and search for new markers.
Lihong Zhang, Xinyu Zhao, Enqin Wang, Ye Yang, Liangfeng Hu, Hongkun Xu, Baojun Zhang   +6 more
exaly   +4 more sources

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study [PDF]

Journal of Translational Medicine
Background Bladder cancer (BLCA) is a prevalent malignancy worldwide, with advanced stages linked to poor prognosis. Although immune checkpoint inhibitors (ICIs) show clinical promise in treating both operable and advanced BLCA, predicting patient ...
Xinjia Ding, Enkui Zhang, Zhou Huang, Xiaohui Li, Zhigao Wang, Yanping Wu, Chao Liu, Shikai Wu   +7 more
doaj   +3 more sources