PAMP orchestrates proline metabolic rewiring to suppress LUAD via PYCR1 inhibition
EMBO Molecular MedicineRecent advances in next-generation sequencing have revealed that long non-coding RNAs (lncRNAs) can encode functional micropeptides through small open reading frames (sORFs), altering the perception of the non-coding genome.
Yun Ma +10 more
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Mechanism of SMYD2 promoting stemness maintenance of bladder cancer stem cells by regulating PYCR1 expression and PINK1/Parkin mitophagy pathway. [PDF]
Int J OncolSET and MYND domain-containing protein 2 (SMYD2), an identified protein-lysine methyltransferase, is key for bladder cancer (BC) progression. The tumor-formation capacity and metastatic potential of bladder cancer stem cells (BCSCs) are due to their ...
Chen J, Xiao S, Yan X, Wei Y, Song W.
europepmc +2 more sources
Mitochondrial NADK2-dependent NADPH controls tau oligomer uptake in human neurons. [PDF]
Alzheimers DementAbstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Pardo E +10 more
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Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1. [PDF]
Biochem JΔ1-pyrroline-5-carboxylate (P5C) reductase 1 (PYCR1) catalyzes the NAD(P)H-dependent conversion of L-P5C to L-proline and is one of the most consistently upregulated metabolic enzymes in cancer cells.
Meeks KR +6 more
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Emerging Roles of De Novo Proline Biosynthesis in Human Diseases. [PDF]
FASEB BioadvDe novo proline synthesis, a multi‐step biochemical pathway starting from glutamate, supplies essential protein building blocks. It supports redox balance, cell proliferation, signal transduction, and nucleotide and protein biosynthesis. This tightly regulated pathway, governed by conserved mechanisms, is disrupted in diseases such as cancer and ...
Pei E, Ma J.
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9-Deazaadenosine directly binds PYCR1 and inhibits cancer cell proliferation through disruption of NAD+ metabolism. [PDF]
Transl OncolHighlights • 9-DAA effectively inhibited colon cancer proliferation and metastasis.• 9-DAA directly bound to PYCR1.• PYCR1 was upregulated in colon cancer under hypoxic conditions and in 3D spheroids.• The inhibitory effects of 9-DAA were NAD+-dependent.
Roh J, Ahn I, Choi JR, Ko SK.
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Integrative Analysis of Immune- and Metabolism-Related Genes Identifies Robust Prognostic Signature and PYCR1 as a Carcinogenic Regulator in Clear Cell Renal Cell Carcinoma. [PDF]
Int J Mol SciClear cell renal cell carcinoma (ccRCC) is distinguished by metabolic irregularities and unique immunological profiles. Nevertheless, the comprehensive examination of immune and metabolic attributes within the tumor microenvironment of ccRCC remains ...
Zhao G +6 more
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Research Progress on the Role and Mechanisms of PYCR1 in Tumorigenesis and Progression [PDF]
Chinese Journal of Lung CancerPyrroline-5-carboxylate reductase 1 (PYCR1) is a key enzyme in the proline biosynthesis pathway and has garnered widespread attention in the field of tumor research in recent years.
Yuqi MENG +4 more
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Machine Learning–Based Identification and Validation of PYCR1 and PYGM as Prognostic Biomarkers for Osteosarcoma [PDF]
Clinical Medicine Insights: OncologyBackground: Osteosarcoma (OS) is a malignant tumor originating in the bones, predominantly affecting children and adolescents, characterized by high aggressiveness and poor prognosis.
Guoyong Xu +7 more
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Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities [PDF]
Cells, 2019 Aging is a natural process that internal gene control and external stimuli mediate. Clinical data pointed out that homozygotic or heterozygotic mutation in the pyrroline-5-carboxylate reductase 1 (PYCR1) gene in humans caused cutis laxa (ARCL) disease ...
Sung-Tzu Liang +7 more
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