Results 41 to 50 of about 1,975 (157)

A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation

Allergology International
Background: Allergic asthma is largely dominated by Th2 lymphocytes. Micropeptides in Th2 cells and asthma remain unmasked. Here, we aimed to demonstrate a micropeptide, T-cell regulatory micropeptide (TREMP), in Th2 cell differentiation in asthma ...
Zhengxia Wang, Xinyu Jia, Wei Sun, Min Wang, Qi Yuan, Tingting Xu, Yanan Liu, Zhongqi Chen, Mao Huang, Ningfei Ji, Mingshun Zhang   +10 more
doaj   +2 more sources

Crystallographic fragment screening reveals new starting points for PYCR1 inhibitor design.

Bioorganic Chemistry
Pyrroline-5-carboxylate (P5C) reductase catalyzes the final step in proline biosynthesis. Human P5C reductase isoform 1 (PYCR1) has emerged as a key metabolic enzyme supporting cancer progression through its roles in redox homeostasis, collagen ...
W. Ragin-Oh, D. Czerwonka, L. H. Tran, Giuseppe Forlani, M. Ruszkowski   +4 more
semanticscholar   +4 more sources

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Structural Dynamics
The proline biosynthetic enzyme Δ1-pyrroline-5-carboxylate (P5C) reductase 1 (PYCR1) is one of the most consistently upregulated enzymes across multiple cancer types and central to the metabolic rewiring of cancer cells. Many studies have shown that high
Kaylen R. Meeks, Juan Ji, Mykola V. Protopopov, Olga O. Tarkhanova, Yurii Moroz, John J. Tanner   +5 more
semanticscholar   +4 more sources

PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells.

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
BACKGROUND Hepatocellular carcinoma (HCC) is a global malignant tumor type. Pyrroline-5-carboxylate reductase 1 (PYCR1) is a metabolic enzyme that exhibits pro-tumor properties in cancer progression. However, the exact molecular mechanism of PYCR1 in HCC
Junli Zhang, Yachao Hou, Xinxin Jin, Biao Gu, Wenjuan Wu   +4 more
semanticscholar   +2 more sources

Integrated Proteomics and Machine Learning Approach Reveals PYCR1 as a Novel Biomarker to Predict Prognosis of Sinonasal Squamous Cell Carcinoma. [PDF]

Int J Mol Sci
Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with a high 5-year mortality rate. However, proteomic technologies have not yet been utilized to identify SNSCC-associated proteins, which could be used as biomarkers.
Panthong W, Pientong C, Nukpook T, Roytrakul S, Yingchutrakul Y, Teeramatwanich W, Aromseree S, Ekalaksananan T.   +7 more
europepmc   +2 more sources

Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1). [PDF]

Protein Sci
Δ1‐pyrroline‐5‐carboxylate reductase isoform 1 (PYCR1) is the last enzyme of proline biosynthesis and catalyzes the NAD(P)H‐dependent reduction of Δ1‐pyrroline‐5‐carboxylate to L‐proline.
Meeks KR, Bogner AN, Tanner JJ.
europepmc   +2 more sources

PYCR1 induces ferroptosis via the PI3K/Akt signaling pathway to regulate the proliferation and migration of osteosarcoma

Translational Oncology
Osteosarcoma treatment outcomes are compromised by increased drug resistance, distant metastasis, and tumor recurrence. While Pyrrolidine-5-carboxylic acid reductase 1(PYCR1) knockdown has been shown to inhibit tumor proliferation and migration in ...
Jianhua Hu, Yiyuan Huang, Haoming Chen, Zehao Xie, Han Yan, Haomiao Li, Runguang Li   +6 more
doaj   +2 more sources

Coexistence of PYCR1-related cutis laxa and bilateral grade V vesicoureteral reflux with reflux nephropathy: A case report

SAGE Open Medical Case Reports
PYCR1-related cutis laxa (autosomal recessive cutis laxa type IIB) is a rare inherited connective tissue disorder characterized by loose, inelastic skin, and variable multisystem involvement.
Dorna Derakhshan, Faizan Bashir, Ali Derakhshan   +2 more
doaj   +2 more sources

Author Correction: Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells. [PDF]

Exp Mol Med
Park JM, Su YH, Fan CS, Chen HH, Qiu YK, Chen LL, Chen HA, Ramasamy TS, Chang JS, Huang SY, Chang WW, Lee AY, Huang TS, Kuo CC, Chiu CF.   +14 more
europepmc   +2 more sources

Machine learning identification of a novel vasculogenic mimicry-related signature and FOXM1’s role in promoting vasculogenic mimicry in clear cell renal cell carcinoma [PDF]

Translational Oncology
Background: Clear Cell Renal Cell Carcinoma (ccRCC), the predominant subtype of renal cell carcinoma (RCC), ranks among the most common malignancies worldwide. Vasculogenic mimicry (VM) plays a pivotal role in tumor progression, being closely linked with
Chao Xu, Sujing Zhang, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Shengtao Dai, Bowei Zhang, Meng Zhu, Yuepeng Liu, Junfei Gu   +10 more
doaj   +2 more sources