Results 61 to 70 of about 1,975 (157)

Metabolomic and transcriptomic studies of improvements in myocardial infarction due to Pycr1 deletion

Journal of Cellular and Molecular Medicine, 2022
AbstractMyocardial infarction (MI) remains a major challenge to cardiovascular health worldwide, with poor healing leaving a direct impact on patients' quality of life and survival. Metabolic abnormalities after MI are receiving increasing attention. Our previous studies showed that enhancing proline catabolism ameliorates hypoxic damage to myocardial ...
Zhimin Xue, Yiwen Pan, Xugang Kong, Jiefang Zhang, Danyu Wu, Binquan Zhou   +5 more
openaire   +2 more sources

Mutations in PYCR1 cause cutis laxa with progeroid features

Nature Genetics, 2009
Autosomal recessive cutis laxa (ARCL) describes a group of syndromal disorders that are often associated with a progeroid appearance, lax and wrinkled skin, osteopenia and mental retardation. Homozygosity mapping in several kindreds with ARCL identified a candidate region on chromosome 17q25. By high-throughput sequencing of the entire candidate region,
Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng SC, Li Y, Shboul M, Tham PY, Kayserili H, Al-Gazali L, Shahwan M, Brancati F, Lee H, O'Connor BD, Schmidt-von Kegler M, Merriman B, Nelson SF, Masri A, Alkazaleh F, Guerra D, Ferrari P, Nanda A, Rajab A, Markie D, Gray M, Nelson J, Grix A, Sommer A, Savarirayan R, Janecke AR, Steichen E, Sillence D, Hausser I, Budde B, Nürnberg G, Nürnberg P, Seemann P, Kunkel D, Zambruno G, Dallapiccola B, Schuelke M, Robertson S, Hamamy H, Wollnik B, Van Maldergem L, Mundlos S, Kornak U   +46 more
openaire   +4 more sources

The clinical significance of PYCR1 expression in renal cell carcinoma

Medicine, 2019
Abstract Pyrroline-5-carboxylate reductase 1 (PYCR1) is an enzyme involved in cell metabolism and is upregulated in cancer. However, the correlations of PYCR1 expression with the clinicopathological features and prognosis of renal cell carcinoma (RCC) remain unclear.
Weijin, Fu, Zhibin, Xie, Shengfeng, Zheng, Xiaoli, Yang, Qijian, Ding, Jiayi, Liu, Qiumei, Liang, Yilong, Chen, Hua, Mi, Deyun, Liu, Jiwen, Cheng   +10 more
openaire   +2 more sources

Genotype–phenotype spectrum of PYCR1-related autosomal recessive cutis laxa

Molecular Genetics and Metabolism, 2013
Autosomal recessive cutis laxa type 2B (ARCL2B; OMIM # 612940) is a segmental progeroid disorder caused by mutations in PYCR1 encoding pyrroline-5-carboxylate reductase 1, which is part of the conserved proline de novo synthesis pathway. Here we describe 33 patients with PYCR1-related ARCL from 27 families with initial diagnoses varying between wrinkly
Dimopoulou, A., Fischer, B., Gardeitchik, T., Gardeitchik, T., Schroter, P., Kayserili, H., Schlack, C., Li, Y., Brum, J.M., Barisic, I., Castori, M., Spaich, C., Fletcher, E., Mahayri, Z., Bhat, M., Girisha, K.M., Lachlan, K., Johnson, D., Phadke, S., Gupta, N., Simandlova, M., Kabra, M., David, A., Nijtmans, L.G.J., Chitayat, D., Tuysuz, B., Brancati, F., Mundlos, S., van Maldergem, L., Morava, E., Wollnik, B., Kornak, U.   +31 more
openaire   +9 more sources

Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis [PDF]

Biochemical and Biophysical Research Communications, 2017
Acute pancreatitis has several underlying etiologies, and results in consequences ranging from mild to complex multi-organ failure. The wide range of pathology suggests a genetic predisposition for progression. We compared the susceptibility to acute pancreatitis in BALB/c and FVB/N mice, coupled with proteomic analysis, in order to identify potential ...
Sapna Iyer, Min-Jung Park, David Moons, Raymond Kwan, Jian Liao, Li Liu, M. Bishr Omary   +6 more
openaire   +2 more sources

Increased PYCR1 mRNA predicts poor prognosis in kidney adenocarcinoma

Medicine, 2021
Abstract The pyrroline-5-carboxylate reductase 1 (PYCR1) plays important roles in cancers, but its contribution to adenocarcinoma of the kidney (AK) and the potential mechanism remain to be clarified. In this study, we aimed to demonstrate the relationship between PYCR1 mRNA and AK based on The Cancer Genome Atlas database.
Tianyi Zhang, Ying Liu, Wenqiang Liu, Qunwang Li, Wei Hou, Ying Huang, Pan Lv, Lu Meng, Yinhua Li, Yunge Jia, Xuezheng Liu, Zhongfu Zuo   +11 more
openaire   +2 more sources

Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis

Discover Oncology, 2022
CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous cell carcinoma (ESCC) have not been fully elucidated.
Cui-juan Qian, Yi-yang Tong, Lin-ken Wu, Yi-chao Wang, Xiao-sheng Teng, Jun Yao   +5 more
doaj   +1 more source

Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia

Journal of Experimental & Clinical Cancer Research, 2023
Background Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma (OSCC), but the high rate of drug resistance limits its clinical application and the underlying mechanisms
Kang Fang, Mingchuang Sun, Zhuyun Leng, Yuan Chu, Ziying Zhao, Zhaoxing Li, Yunwei Zhang, Aiping Xu, Zehua Zhang, Li Zhang, Tao Chen, Meidong Xu   +11 more
doaj   +1 more source

P5CR1 protein expression and the effect of gene-silencing on lung adenocarcinoma [PDF]

PeerJ, 2019
The present study aimed to investigate the expression of pyrroline-5-carboxylate reductase 1 (P5CR1) protein in lung adenocarcinoma and paracancerous tissues and to explore the effect of silencing the encoding gene PYCR1 on the proliferation, migration ...
Yang She, Aiyou Mao, Feng Li, Xiaobin Wei   +3 more
doaj   +2 more sources

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source