Results 1 to 10 of about 4,112 (128)

Chromosome 1 Open Reading Frame 35 Drives Colorectal Cancer Progression by Enhancing Tumor‐Intrinsic Proliferation and CD8+ T Cell Suppression [PDF]

MedComm
The functional significance of Chromosome 1 open reading frame 35 (C1orf35) in colorectal cancer (CRC) remains poorly characterized. This study investigates its oncogenic role and underlying mechanisms. We report that C1orf35 is frequently upregulated in
Shaosen Zhang, Changjiang Yang, Xunye Xu, Lan Lan, Ziyi He, Jiaoting Chen, Caihong Wang   +6 more
doaj   +3 more sources

Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress [PDF]

Cell Death and Disease, 2023
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui, Bin He, Yanping Huang, Cenxin Wang, Huandong Luo, Jinxin Lu, Keyu Su, Xiaoyu Zhang, Yuanyuan Luo, Zhuoran Zhao, Yuqing Yang, Yunkun Zhang, Fan An, Hong Wang, Eric W.-F. Lam, Keith W. Kelley, Ling Wang, Quentin Liu, Fei Peng   +18 more
doaj   +2 more sources

Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Murphy Roths Large (MRL) mice possess outstanding capacity to regenerate several tissues. In the present study, we investigated whether this regenerative potential could be associated with the intrinsic particularities possessed by their mesenchymal stem
Gautier Tejedor, Rafael Contreras-Lopez, Audrey Barthelaix, Maxime Ruiz, Danièle Noël, Danièle Noël, Frédéric De Ceuninck, Philippe Pastoureau, Patricia Luz-Crawford, Christian Jorgensen, Christian Jorgensen, Farida Djouad   +11 more
doaj   +2 more sources

Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis [PDF]

Journal of Experimental & Clinical Cancer Research, 2022
Background Multiple myeloma (MM) remains an incurable cancer despite advances in therapy. Therefore, the search for new targets is still essential to uncover potential treatment strategies.
Inge Oudaert, Hatice Satilmis, Philip Vlummens, Wouter De Brouwer, Anke Maes, Dirk Hose, Elke De Bruyne, Bart Ghesquière, Karin Vanderkerken, Kim De Veirman, Eline Menu   +10 more
doaj   +2 more sources

Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma [PDF]

Cancer Management and Research, 2018
Yingyi Ye,1,* Yingying Wu,2,* Jinyan Wang1 1Department of Dermatology, Ningbo No.2 Hospital, Ningbo, Zhejiang, China; 2Department of Oncology, Ningbo No.2 Hospital, Ningbo, Zhejiang, China *These authors contributed equally to this work Introduction ...
Ye Y, Wu Y, Wang J
doaj   +2 more sources

The Substrate Versatility of Δ¹-Pyrroline-5-carboxylate Reductase (ProC) from Escherichia coli [PDF]

Molecules
Δ1-Pyrroline-5-carboxylate reductase (EC 1.5.1.2; called ProC in most bacteria) is an enzyme of central metabolism that catalyzes the last step of the proline biosynthetic pathways, namely the NADPH-dependent reduction of pyrroline-5-carboxylate (P5C) to
Eugenia Polverini, Alessandro Vecchi, Giulia Capra, Alessia Pastori, Alessio Peracchi   +4 more
doaj   +2 more sources

The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Pyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa ...
Peng Guo, Chenchun Wu, Tong Wang, Yajuan Song, Xiaozi Liu, Xiang Wang, Yuhan Zhu, Binyu Song, Yifu Zhu, Juan Zhang, Lei Guo, Rui Tao, Zhou Yu, Baoqiang Song   +13 more
doaj   +2 more sources

Research Progress on the Role and Mechanisms of PYCR1 
in Tumorigenesis and Progression [PDF]

Chinese Journal of Lung Cancer
Pyrroline-5-carboxylate reductase 1 (PYCR1) is a key enzyme in the proline biosynthesis pathway and has garnered widespread attention in the field of tumor research in recent years.
Yuqi MENG, Zhichang YANG, Haiming FENG, Haitian LI, Bin LI   +4 more
doaj   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism. [PDF]

Mol Oncol
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Oudaert I, van den Broecke L, Aksoy O, Lind J, Vallet S, Van der Vreken A, Ates G, Massie A, Maes K, De Veirman K, De Bruyne E, Vanderkerken K, Podar K, Menu E.   +13 more
europepmc   +2 more sources

Proline–Nitrogen Metabolic Coordination Mediates Cold Priming-Induced Freezing Tolerance in Maize [PDF]

Plants
Cold stress critically restricts maize seedling growth in Northeast China, yet the mechanism by which cold priming (CP) enhances cold tolerance through proline–nitrogen metabolic networks remains unclear.
Zhijia Gai, Lei Liu, Na Zhang, Jingqi Liu, Lijun Cai, Xu Yang, Ao Zhang, Pengfei Zhang, Junjie Ding, Yifei Zhang   +9 more
doaj   +2 more sources