Results 41 to 50 of about 4,162 (161)

Serum autoantibody profiling of oral squamous cell carcinoma patients reveals NUBP2 as a potential diagnostic marker

Frontiers in Oncology, 2023
IntroductionOral Squamous Cell Carcinoma (OSCC), a common malignancy of the head and neck region, is frequently diagnosed at advanced stages, necessitating the development of efficient diagnostic methods.
Riaz Abdulla, Jofy Devasia Puthenpurackal, Sneha M. Pinto, Sneha M. Pinto, Punchappady Devasya Rekha, Yashwanth Subbannayya, Yashwanth Subbannayya   +6 more
doaj   +1 more source

Pro-tumorigenic activity of PYCR1 in gastric cancer through regulating the PI3K/AKT signaling

Heliyon
Background: The primary objective of this investigation was to assess the impact of pyrroline-5-carboxylate reductase 1 (PYCR1) on the progression of gastric cancer (GC), specifically focusing on tumor growth and metastatic potential.
Huijie Xiao, Jiannan Huang, Haitao Wu, YuYing Li, Yizhuo Wang   +4 more
doaj   +1 more source

Defect in proline synthesis: pyrroline‐5‐carboxylate reductase 1 deficiency leads to a complex clinical phenotype with collagen and elastin abnormalities [PDF]

Journal of Inherited Metabolic Disease, 2011
AbstractPyrroline‐5‐carboxylate reductase 1 (PYCR1) catalyzes the last step in proline synthesis. Deficiency of PYCR1, caused by a defect in PYCR1, was recently described in patients with cutis laxa, intrauterine growth retardation, developmental dysplasia of the hips and mental retardation.
Kretz, R, Bozorgmehr, B, Kariminejad, M H, Rohrbach, M, Hausser, I, Baumer, A, Baumgartner, Matthias R, Giunta, C, Kariminejad, A, Häberle, J   +9 more
openaire   +3 more sources

P5CR1 protein expression and the effect of gene-silencing on lung adenocarcinoma [PDF]

PeerJ, 2019
The present study aimed to investigate the expression of pyrroline-5-carboxylate reductase 1 (P5CR1) protein in lung adenocarcinoma and paracancerous tissues and to explore the effect of silencing the encoding gene PYCR1 on the proliferation, migration ...
Yang She, Aiyou Mao, Feng Li, Xiaobin Wei   +3 more
doaj   +2 more sources

Design Principles of Plant Thermotolerance: Integrating Photosynthesis, Reproduction, and Field Resilience in a Warming Climate

Plant, Cell &Environment, EarlyView.
ABSTRACT Global food security is increasingly threatened by climate change, as rising temperatures compromise the yields of major staple crops, including wheat, rice, and maize. Enhancing plant thermotolerance has therefore become a critical priority for sustaining agricultural productivity.
Yuchen Qu, Wataru Yamori
wiley   +1 more source

Phytotoxicity of aminobisphosphonates targeting both δ¹‐pyrroline‐5‐carboxylate reductase and glutamine synthetase

Pest Management Science, 2016
AbstractBACKGROUNDDual‐target inhibitors may contribute to the management of herbicide‐resistant weeds and avoid or delay the selection of resistant biotypes. Some aminobisphosphonates inhibit the activity of both glutamine synthetase and δ1‐pyrroline‐5‐carboxylate (P5C) reductase in vitro, but the relevance of the latter in vivo has yet to be proven ...
GIBERTI, Samuele, BERTAZZINI, Michele, Liboni, Mattia, Berlicki, Łukasz, Kafarski, Paweł, FORLANI, Giuseppe   +5 more
openaire   +3 more sources

Advancing Thermotolerance in Beans: Integrating Physiology, Genomics, and Breeding for Climate Adaptation

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Rising global temperatures increasingly threaten bean production and the food security of millions of people who depend on these protein‐rich legumes. Heat stress during the reproductive stages induces pollen sterility, flower abscission, and disruptions in source–sink relationships, resulting in yield losses of 30%–40% or more when critical ...
Aastha Sharda, Shikha Chaudhary, Bhawna Kumari, Uday C. Jha, Mohar Singh, Inderjit Singh, Kamal Dev Sharma, Kadambot H. M. Siddique, P. V. Vara Prasad, Harsh Nayyar   +9 more
wiley   +1 more source

Subcellular Location of Δ¹-Pyrroline-5-Carboxylate Reductase in Root/Nodule and Leaf of Soybean [PDF]

Plant Physiology, 1992
The expression of Delta(1)-pyrroline-5-carboxylate reductase (P5CR) gene was found to be higher in soybean root nodules than in leaves and roots, and its expression in roots appeared to be osmoregulated (AJ Delauney, DPS Verma [1990] Mol Gen Genet 221: 299-305). P5CR was purified to homogeneity as a monomeric protein of 29 kilodaltons by overexpression
Annamaria Szoke, Guo-Hua Miao, Zonglie Hong, Desh Pal S. Verma   +3 more
openaire   +1 more source

Proline Metabolism in Response to Climate Extremes in Hairgrass

Plants
Hairgrass (Deschampsia caespitosa), a widely distributed grass species considered promising in the ecological restoration of degraded grassland in the Qinghai-Xizang Plateau, is likely to be subjected to frequent drought and waterlogging stress due to ...
Qiaoyu Luo, Yonggui Ma, Huichun Xie, Feifei Chang, Chiming Guan, Bing Yang, Yushou Ma   +6 more
doaj   +1 more source

Expression profiling reveals novel hypoxic biomarkers in peripheral blood of adult mice exposed to chronic hypoxia. [PDF]

PLoS ONE, 2012
Hypoxia induces a myriad of changes including an increase in hematocrit due to erythropoietin (EPO) mediated erythropoiesis. While hypoxia is of importance physiologically and clinically, lacunae exist in our knowledge of the systemic and temporal ...
Matias Mosqueira, Gabriel Willmann, Ulrike Zeiger, Tejvir S Khurana   +3 more
doaj   +1 more source