Results 51 to 60 of about 4,162 (161)

GK PUA Domain Modulates Cables, Cooperativity, and Proline Feedback

Aggregate, Volume 7, Issue 8, August 2026.
EcGK tetramers hierarchically assemble into metabolic filaments and bundle into metabolic cables. Upon substrate binding, this dynamic equilibrium shifts from inactive cables to active tetramers to drive catalysis; meanwhile the inhibitor proline stabilizes an X‐shaped conformation, redirecting assembly toward filaments to enable efficient feedback ...
Tianyi Zhang, Qingqing Leng, Siran Li, Huan‐Huan Hu, Ji‐Long Liu   +4 more
wiley   +1 more source

The structure of Medicago truncatula δ1-pyrroline-5-carboxylate reductase provides new insights into regulation of proline biosynthesis in plants [PDF]

Frontiers in Plant Science, 2015
The two pathways for proline biosynthesis in higher plants share the last step, the conversion of δ(1)-pyrroline-5-carboxylate (P5C) to L-proline, which is catalyzed by P5C reductase (P5CR, EC 1.5.1.2) with the use of NAD(P)H as a coenzyme. There is increasing amount of evidence to suggest a complex regulation of P5CR activity at the post-translational
Ruszkowski, Milosz, Nocek, Boguslaw, FORLANI, Giuseppe, Dauter, Zbigniew   +3 more
openaire   +3 more sources

Exogenous proline enhances salt acclimation in soybean seedlings: Modifying physicochemical properties and controlling proline metabolism through the ornithine-glutamate dual pathway

Ecotoxicology and Environmental Safety
Soil salinization has emerged as a major factor negatively affecting soil quality and plant productivity. Proline, functioning as an osmotic regulator, has been proposed as an effective strategy for enhancing plant tolerance to salt stress.
Lei Yan, Mu Lu, Muhammad Riaz, Kaiqing Tong, Hualong Yu, Guang Gao, Yusheng Niu   +6 more
doaj   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Preparation of Phosphonic Acid Analogues of Proline and Proline Analogues and Their Biological Evaluation as δ¹-Pyrroline-5-carboxylate Reductase Inhibitors [PDF]

ACS Omega, 2018
Racemic 1-hydroxy-3-butenyl-, 3-chloro-1-hydroxypropyl-, and 3-bromo-1-hydroxypropylphosphonate and the corresponding (S)-enantiomers obtained by lipase-catalyzed resolution of the respective racemic chloroacetates were subjected to functional group manipulations.
Renzhe Qian, Thomas Kalina, Jeannie Horak, Samuele Giberti, Giuseppe Forlani, Friedrich Hammerschmidt   +5 more
openaire   +4 more sources

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2838-2868, August 2026.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

Neoplasia: An International Journal for Oncology Research, 2019
SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported.
Shuaiyi Chen, Xin Yang, Miao Yu, Zhe Wang, Boya Liu, Minghui Liu, Lu Liu, Mengmeng Ren, Hao Qi, Junhua Zou, Ivana Vucenik, Wei-Guo Zhu, Jianyuan Luo   +12 more
doaj   +1 more source

Molecular and Biochemical Insights Into Early Responses of Hemp to Cd and Zn Exposure and the Potential Effect of Si on Stress Response

Frontiers in Plant Science, 2021
With the intensification of human activities, plants are more frequently exposed to heavy metals (HM). Zinc (Zn) and cadmium (Cd) are frequently and simultaneously found in contaminated soils, including agronomic soils contaminated by the atmospheric ...
Marie Luyckx, Jean-François Hausman, Kjell Sergeant, Gea Guerriero, Stanley Lutts   +4 more
doaj   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Metabolic design considerations for recycling of respiratory CO2 in leaves

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Net carbon gain in plants is significantly reduced by the loss of assimilated carbon due to respiration and other metabolism in heterotrophic tissues. Avoiding this loss is difficult due to the essential nature of the metabolic processes involved but it could be possible to engineer metabolism to reuse the generated CO2.
Corinna Hartinger, Edward N. Smith, Lee J. Sweetlove   +2 more
wiley   +1 more source