Results 71 to 80 of about 4,162 (161)

PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification

Clinical and Translational Medicine
Background Liver cancer (LC) is among the deadliest cancers worldwide, with existing treatments showing limited efficacy. This study aimed to elucidate the role and underlying mechanisms of pyrroline‐5‐carboxylate reductase 1 (PYCR1) as a potential ...
Haoyu Wang, Mu Xu, Tong Zhang, Jinkun Pan, Chaopu Li, Bei Pan, Linpeng Zhou, Yun Huang, Chenzi Gao, Mengping He, Yao Xue, Xuetao Ji, Xu Zhang, Ning Wang, Hongwen Zhou, Qian Wang, John Zhong Li   +16 more
doaj   +1 more source

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2‐Oxoglutarate Binding Mode and Conformation

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Studies with naturally occuring variants of the Pseudomonas savastanoi ethylene‐forming enzyme (PsEFE) inform on the effect of residues on turnover and product ratio. Crystallographic studies imply a potential for metal ion sensing. Pseudomonas savastanoi pv.
Yihong Sun, Siddhant Dhingra, Mark D. Allen, Ethan S. Z. Cheng, Zhihong Zhang, Christopher J. Schofield, Lennart Brewitz   +6 more
wiley   +1 more source

Mitigating drought stress and enhancing quinoa productivity using iron and zinc nanoparticles

Agrosystems, Geosciences &Environment, Volume 9, Issue 1, March 2026.
Abstract In recent years, the cultivation area and consumption of quinoa (Chenopodium quinoa Willd) have increased in the country due to its nutritional properties and ability to grow in adverse conditions. Based on climate change scenarios, long periods of drought are expected, which emphasizes the need for planting and developing new plants that are ...
Nasim Pakbaz, Heshmat Omidi, Mohammad Hosein Bijeh Keshavarzi   +2 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Effects of Organic Fertilizer Substitution for Chemical Fertilizer on Grain Yield and 2-Acetyl-1-pyrroline (2-AP) of Fragrant Rice

Agronomy
Organic fertilizer replacing a portion of chemical fertilizers is a key strategy for improving grain qualities and economic benefits. Fragrant rice, favored by consumers for its superior quality and rich aroma, has garnered significant attention. However,
Yihang Jiang, Jiayi Dai, Xiaojuan Pu, Yanyue Liang, Deqian Chen, Shenggang Pan   +5 more
doaj   +1 more source

A PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation.

PLoS ONE, 2014
We recently revealed that myeloid master regulator SPI1/PU.1 directly represses metallothionein (MT) 1G through its epigenetic activity of PU.1, but the functions of MT1G in myeloid differentiation remain unknown.
Naomi Hirako, Hiroko Nakano, Shinichiro Takahashi   +2 more
doaj   +1 more source

Genome‐Wide Association Study and RNA Sequencing Identify Candidate Genes Regulating Nitrogen Use Efficiency and Associated Traits in Sorghum (Sorghum bicolor (L.) Moench)

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Sorghum (Sorghum bicolor L. Moench) is a resilient cereal crop with remarkable adaptability to diverse environments. Nitrogen use efficiency (NUE) is critical for improving sorghum yields, resource utilization, livelihood security, and environmental sustainability of the target ecologies.
Srikanth Bollam, Laavanya Rayaprolu, Kirandeep Kaur Romana, Pradeep Ruperao, Sivasubramani Selvanayagam, Anil Kumar Vemula, Gopikrishna Adapala, Vinod Kumar Valluri, Prasad Bajaj, Abhishek Rathore, Damaris A. Odeny, Rakesh K. Srivastava, Santosh P. Deshpande, Rajeev Gupta   +13 more
wiley   +1 more source

Transcriptional Analysis and Genome‐Wide Identification of HA, FRO, and IRT Gene Families Reveal Key Regulators in Pear Seedlings to Short‐Term Iron Deficiency Stress

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Iron (Fe) is an essential micronutrient for plant photosynthesis and human health. Pear represents a widely consumed fruit for human Fe intake, yet its yield and quality are frequently challenged by Fe deficiency (FD) stress. Despite the prevalence of FD stress in agricultural production under generally alkaline and calcareous conditions, pear
Guoling Guo, Haoguo Liu, Le Xu, Xinxin Wang, Mengxue Xia, Zhiwen Gao, Lun Liu, Wei Heng, Zhenfeng Ye, Li Liu, Bing Jia, Xiaomei Tang   +11 more
wiley   +1 more source

PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Hepatocellular carcinoma (HCC) is a global malignant tumor type. Pyrroline‐5‐carboxylate reductase 1 (PYCR1) is a metabolic enzyme that exhibits pro‐tumor properties in cancer progression. However, the exact molecular mechanism of PYCR1 in HCC progression is still unclear.
Junli Zhang, Yachao Hou, Xinxin Jin, Biao Gu, Wenjuan Wu, Shih-Min Hsia   +5 more
wiley   +1 more source

Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities

Cells, 2019
Aging is a natural process that internal gene control and external stimuli mediate. Clinical data pointed out that homozygotic or heterozygotic mutation in the pyrroline-5-carboxylate reductase 1 (PYCR1) gene in humans caused cutis laxa (ARCL) disease ...
Sung-Tzu Liang, Gilbert Audira, Stevhen Juniardi, Jung-Ren Chen, Yu-Heng Lai, Zheng-Cai Du, Dar-Shong Lin, Chung-Der Hsiao   +7 more
doaj   +1 more source