Results 81 to 90 of about 4,162 (161)

Overexpression of a barley aquaporin gene, HvPIP2;5 confers salt and osmotic stress tolerance in yeast and plants

Frontiers in Plant Science, 2016
We characterized an aquaporin gene HvPIP2;5 from Hordeum vulgare and investigated its physiological roles in heterologous expression systems, yeast and Arabidopsis, under high salt and high osmotic stress conditions.
Hemasundar Alavilli, Jay Prakash Awasthi, Gyana Ranjan Rout, Lingaraj Sahoo, Byeong-ha Lee, Sanjib Kumar Panda   +5 more
doaj   +1 more source

Effect of dopamine and progesterone on the physiological and molecular responses of tomato seedlings to drought and salt stress

Cogent Food & Agriculture
Drought and salt stress are the most common abiotic stresses resulting in yield reduction or complete loss of agricultural production in recent years.
Ufuk Celikkol Akcay, Reyhan Gencay, Fatma Zehra Koc   +2 more
doaj   +1 more source

Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism

Cancer Biology & Therapy
Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. This study investigated how PYCR1 promotes BC progression through glycolysis, histone H3 Lysine 18 Lactylation ...
Zhuo Li, Qinghua Jiang, Quan Yang, Yujie Zhou, Jiansong Wang   +4 more
doaj   +1 more source

Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells

Experimental and Molecular Medicine
Ferritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels.
Ji Min Park, Yen-Hao Su, Chi-Shuan Fan, Hsin-Hua Chen, Yuan-Kai Qiu, Li-Li Chen, Hsin-An Chen, Thamil Selvee Ramasamy, Jung-Su Chang, Shih-Yi Huang, Wun-Shaing Wayne Chang, Alan Yueh-Luen Lee, Tze-Sing Huang, Cheng-Chin Kuo, Ching-Feng Chiu   +14 more
doaj   +1 more source

Cardiac endothelial ischemia/reperfusion injury-derived protein damage-associated molecular patterns disrupt the integrity of the endothelial barrier

Heliyon
Human cardiac microvascular endothelial cells (HCMECs) are sensitive to ischemia and vulnerable to damage during reperfusion. The release of damage-associated molecular patterns (DAMPs) during reperfusion induces additional tissue damage.
Sarawut Kumphune, Porrnthanate Seenak, Nitchawat Paiyabhrom, Worawat Songjang, Panyupa Pankhong, Noppadon Jumroon, Siriwan Thaisakun, Narumon Phaonakrop, Sittiruk Roytrakul, Wachirawadee Malakul, Arunya Jiraviriyakul, Nitirut Nernpermpisooth   +11 more
doaj   +1 more source

A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell differentiation by interacting with PYCR1 in allergic airway inflammation

Allergology International
Background: Allergic asthma is largely dominated by Th2 lymphocytes. Micropeptides in Th2 cells and asthma remain unmasked. Here, we aimed to demonstrate a micropeptide, T-cell regulatory micropeptide (TREMP), in Th2 cell differentiation in asthma ...
Zhengxia Wang, Xinyu Jia, Wei Sun, Min Wang, Qi Yuan, Tingting Xu, Yanan Liu, Zhongqi Chen, Mao Huang, Ningfei Ji, Mingshun Zhang   +10 more
doaj   +1 more source

Guanidine production by plant homoarginine-6-hydroxylases

eLife
Metabolism and biological functions of the nitrogen-rich compound guanidine have long been neglected. The discovery of four classes of guanidine-sensing riboswitches and two pathways for guanidine degradation in bacteria hint at widespread sources of ...
Dietmar Funck, Malte Sinn, Giuseppe Forlani, Jörg S Hartig   +3 more
doaj   +1 more source

PYCR1 drives lung cancer progression through functional interactions with EGFR and TLR signaling pathways

Experimental and Molecular Medicine
Lung cancer, particularly non-small-cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality worldwide. Recent studies have implicated pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme in proline biosynthesis, in cancer ...
Ji Hye Shin, Ji Young Kim, Mi-Jeong Kim, Yeeun Kang, Ha-Jeong Lee, Bongkum Choi, Ji Su Lee, Dohee Kwon, Seo Hyun Kim, Yoolim Sung, Duk-Hwan Kim, Jae-Hyuck Shim, Eunyoung Chun, Ki-Young Lee   +13 more
doaj   +1 more source

Pyrroline-5-carboxylate reductase 1 (PYCR1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Pyrroline-5-carboxylate reductase 1, PYCR1, is differentially expressed in non-small cell lung cancer and associates with patient survival.

, 2020
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding pyrroline-5-carboxylate reductase 1, PYCR1, was among those whose expression was most quantitatively different in human ...
openaire   +2 more sources