Pyrroline-5-carboxylate reductase 1

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pyrroline-5-carboxylate reductase 1 (PYCR1): Machine learning discoveries of 2nd order synergy in Meningiomas

Background : PYCR1 catalyzes the NAD(P)H-dependent conversion of pyrroline- 5-carboxylate to proline. It has been implicated in progeroid disease, Autosomal-recessive cutis laxa type 2, geroderma osteodysplasticum, mental retardation, non- small cell lung cancer, prostate cancer, Hutchinson-Gilford progeria syndrome, human malignant melanoma ...
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2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

Signal Transduction and Targeted Therapy
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed that
Fu Peng +15 more
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Sublethal endoplasmic reticulum stress caused by the mutation of immunoglobulin heavy chain-binding protein induces the synthesis of a mitochondrial protein, pyrroline-5-carboxylate reductase 1. [PDF]