Results 11 to 20 of about 4,162 (161)

Functional Impact of a Cancer-Related Variant in Human Δ¹-Pyrroline-5-Carboxylate Reductase 1. [PDF]

ACS Omega, 2023
Pyrroline-5-carboxylate reductase (PYCR) is a proline biosynthetic enzyme that catalyzes the NAD(P)H-dependent reduction of Δ1-pyrroline-5-carboxylate (P5C) to proline. Humans have three PYCR isoforms, with PYCR1 often upregulated in different types of cancers. Here, we studied the biochemical and structural properties of the Thr171Met variant of PYCR1,
Daudu OI, Meeks KR, Zhang L, Seravalli J, Tanner JJ, Becker DF.   +5 more
europepmc   +3 more sources

MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1). [PDF]

Bioengineered, 2021
Nasopharyngeal cancer is a rare cancer type, but with a low five-year survival rate. Dysregulation of pyrroline-5-carboxylate reductase 1 (PYCR1) and microRNA hsa-miR-150-5p is involved in the development of various cancers. However, the molecular mechanism of the hsa-miR-150-5p-PYCR1 axis in nasopharyngeal cancer remains unclear.
Li Z, Zhou X, Huang J, Xu Z, Xing C, Yang J, Zhou X.   +6 more
europepmc   +4 more sources

Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. [PDF]

J Biol Chem, 2017
Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of Δ1-pyrroline-5-carboxylate (P5C) to proline. Mutations in the PYCR1 gene alter mitochondrial function and cause the connective tissue disorder cutis laxa.
Christensen EM, Patel SM, Korasick DA, Campbell AC, Krause KL, Becker DF, Tanner JJ.   +6 more
europepmc   +4 more sources

Pyrroline-5-carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non-small cell lung cancer. [PDF]

Oncol Lett, 2018
Disordered tumor cell metabolism is involved in the process of tumorigenesis. Proline metabolism is of critical importance for tumor cells, and pyrroline-5-carboxylate reductase 1 (PYCR1), a key proline biosynthesis enzyme, has been reported to be overexpressed in prostate cancer and to promote tumor cell growth in breast cancer.
Cai F, Miao Y, Liu C, Wu T, Shen S, Su X, Shi Y.   +6 more
europepmc   +4 more sources

LINC00511 aggravates the malignancy of lung adenocarcinoma through sponging microRNA miR-4739 to regulate pyrroline-5-carboxylate reductase 1 expression. [PDF]

J Clin Lab Anal, 2022
AbstractBackgroundLong non‐coding RNA LINC00511 is known to exacerbate lung adenocarcinoma (LUAD) progression. However, the specific mechanism by which LINC00511 affects LUAD progression has not been investigated as yet, and we aimed to elucidate the same in the present study.MethodsThe expression levels of LINC00511, microRNA miR‐4739, and pyrroline‐5‐
Ye L, Wang L, Zeng Y.
europepmc   +3 more sources

Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome. [PDF]

Ann Transl Med, 2020
Proline levels are significantly increased in tumor specimens and urine samples from gastric cancer (GC) patients, and we previously showed that intracellular proline levels significantly differ between human GC cell lines and normal gastric epithelial cells.
Xiao S, Li S, Yuan Z, Zhou L.
europepmc   +4 more sources

Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2. [PDF]

Am J Hum Genet, 2009
Autosomal-recessive cutis laxa type 2 (ARCL2) is a multisystem disorder characterized by the appearance of premature aging, wrinkled and lax skin, joint laxity, and a general developmental delay. Cutis laxa includes a family of clinically overlapping conditions with confusing nomenclature, generally requiring molecular analyses for definitive diagnosis.
Guernsey DL, Jiang H, Evans SC, Ferguson M, Matsuoka M, Nightingale M, Rideout AL, Provost S, Bedard K, Orr A, Dubé MP, Ludman M, Samuels ME.   +12 more
europepmc   +4 more sources

Functional properties and structural characterization of rice δ1-pyrroline-5-carboxylate reductase [PDF]

Frontiers in Plant Science, 2015
The majority of plant species accumulate high intracellular levels of proline to cope with hyperosmotic stress conditions. Proline synthesis from glutamate is tightly regulated at both the transcriptional and the translational levels, yet little is known about the mechanisms for post-translational regulation of the enzymatic activities involved.
FORLANI, Giuseppe, BERTAZZINI, Michele, Zarattini, Marco, Funck, Dietmar, Ruszkowski, Milosz, Nocek, Bogusław   +5 more
openaire   +6 more sources

Melatonin treatment alleviates chilling injury in mango fruit ‘Keitt’ by modulating proline metabolism under chilling stress

Journal of Integrative Agriculture, 2023
Mangoes often suffer from low temperature-induced chilling injury (CI) during postharvest cold storage. Therefore, advanced techniques are crucial and in high demand to solve the chilling stress of mango fruit for a higher value.
Mariama KEBBEH, Jing-xian DONG, Chen HUAN, Yan LIU, Xiao-lin ZHENG   +4 more
doaj   +1 more source

Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1. [PDF]

Biochem J
Abstract Δ1-pyrroline-5-carboxylate (P5C) reductase 1 (PYCR1) catalyzes the NAD(P)H-dependent conversion of L-P5C to L-proline and is one of the most consistently up-regulated metabolic enzymes in cancer cells. High PYCR1 expression is associated with adverse clinical outcomes, and its knockdown inhibits tumor proliferation and ...
Meeks KR, Mattingly CJ, Nix JC, Chuk O, Protopopov MV, Tarkhanova OO, Tanner JJ.   +6 more
europepmc   +2 more sources