Results 51 to 60 of about 1,975 (157)

PYCR1: A Potential Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma [PDF]

Journal of Cancer, 2022
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor with an extremely poor prognosis in digestive tumors. Pyrroline-5-carboxylate reductase 1 (PYCR1) plays an important role in tumor development. Therefore, we aimed to explore the effect of PYCR1 on the growth of PDAC cells.
Wang, Huanyu, Mao, Weilin, Lou, Wenhui, Jin, Dayong, Wu, Wenchuan, Wang, Dansong, Kuang, Tiantao, Rong, Yefei, Xu, Xuefeng, Zhang, Lei   +9 more
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[A pan-cancer analysis of PYCR1 and its predictive value for chemotherapy and immunotherapy responses in bladder cancer]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li Y, Song X, Sun R, Dong X, Liu H.
europepmc   +2 more sources

A fragment-like approach to PYCR1 inhibition [PDF]

Bioorganic & Medicinal Chemistry Letters, 2019
Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer. Due to the role of proline in maintaining the redox balance of cells and preventing apoptosis, PYCR1 is emerging as an attractive oncology target. Previous PYCR1 knockout studies led to
Kirsty Milne, Jianhui Sun, Esther A. Zaal, Jenna Mowat, Patrick H.N. Celie, Alexander Fish, Celia R. Berkers, Giuseppe Forlani, Fabricio Loayza-Puch, Craig Jamieson, Reuven Agami   +10 more
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Author Correction: Mutations in PYCR1 cause cutis laxa with progeroid features [PDF]

Nature Genetics, 2022
In the version of this article initially published, there was an omission in the Acknowledgements section for support to Hülya Kayserili. The Acknowledgements should have ended with the text “and a grant from TUBITAK SBAG-108S418 to H.K.”.
Reversade, Bruno, Escande-Beillard, Nathalie, Dimopoulou, Aikaterini, Fischer, Björn, Chng, Serene C, Li, Yun, Shboul, Mohammad, Tham, Puay-Yoke, Kayserili, Hülya, Al-Gazali, Lihadh, Shahwan, Monzer, Brancati, Francesco, Lee, Hane, O'Connor, Brian D, Kegler, Mareen Schmidt-von, Merriman, Barry, Nelson, Stanley F, Masri, Amira, Alkazaleh, Fawaz, Guerra, Deanna, Ferrari, Paola, Nanda, Arti, Rajab, Anna, Markie, David, Gray, Mary, Nelson, John, Grix, Arthur, Sommer, Annemarie, Savarirayan, Ravi, Janecke, Andreas R, Steichen, Elisabeth, Sillence, David, Haußer, Ingrid, Budde, Birgit, Nürnberg, Gudrun, Nürnberg, Peter, Seemann, Petra, Kunkel, Désirée, Zambruno, Giovanna, Dallapiccola, Bruno, Schuelke, Markus, Robertson, Stephen, Hamamy, Hanan, Wollnik, Bernd, Van Maldergem, Lionel, Mundlos, Stefan, Kornak, Uwe   +46 more
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Genetic analysis of Pycr1 and Pycr2 in mice

Genetics, 2021
Abstract The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to proline. Mutations in human PYCR1 and ALDH18A1 (P5C Synthetase) cause Cutis Laxa (CL), whereas mutations in PYCR2 cause hypomyelinating leukodystrophy 10 (HLD10).
Morgane G Stum, Abigail L D Tadenev, Kevin L Seburn, Kathy E Miers, Pak P Poon, Christopher R McMaster, Carolyn Robinson, Coleen Kane, Kathleen A Silva, Paul F Cliften, John P Sundberg, Laura G Reinholdt, Simon W M John, Robert W Burgess   +13 more
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PYCR in Kidney Renal Papillary Cell Carcinoma: Expression, Prognosis, Gene Regulation Network, and Regulation Targets

Frontiers in Bioscience-Landmark, 2022
Background: Pyrroline-5-carboxylate reductase (PYCR) includes three human genes encoding three isozymes, PYCR1, PYCR2, and PYCR3 (or PYCRL), which facilitate the final step in the conversion of glutamine to proline.
Zheng Shao, Lingling Lu, Yongshi Cui, Li Deng, Qinying Xu, Quanyan Liang, Xiaoyong Lu, Juying Zhang, Jv Chen, Yongli Situ   +9 more
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In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1 [PDF]

Journal of Biological Chemistry, 2020
Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of PYCR1 lead to decreased cell ...
Christensen, Emily M., Bogner, Alexandra N., Vandekeere, Anke, Tam, Gabriela S., Patel, Sagar M., Becker, Donald F., Fendt, Sarah-Maria, Tanner, John J.   +7 more
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Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

Cell Death and Disease, 2023
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive.
Bai Cui, Bin He, Yanping Huang, Cenxin Wang, Huandong Luo, Jinxin Lu, Keyu Su, Xiaoyu Zhang, Yuanyuan Luo, Zhuoran Zhao, Yuqing Yang, Yunkun Zhang, Fan An, Hong Wang, Eric W.-F. Lam, Keith W. Kelley, Ling Wang, Quentin Liu, Fei Peng   +18 more
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PYCR1 Levels Track with Premature and Chronological Skin Aging

, 2023
Abstract De Barsy syndrome is a recessive progeroid disease classified under the group of cutis laxa syndromes. The disease is attributed to loss-of-function mutations in PYCR1 or ALDH18A1, leading to premature skin aging. Here we report five PYCR1 pathogenic alleles and a mouse knockout model of the disease.
Kortessa Sotiropoulou, Saniye Yumlu, Tomoko Hirano, Michael Maier, Abigail Loh, Peh Fern Ong, Onn Siong Yim, Chunping Liu, Emmanuel Vial, Umut Altunoğlu, Sheela Nampoothiri, Deepthi de Silva, Björn Fischer-Zirnsak, Hülya Kayserili, Poh San Lai, Oliver Dreesen, Kenji Kabashima, Uwe Kornak, Nathalie Escande-Beillard, Bruno Reversade   +19 more
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Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma [PDF]

International Journal of Biological Sciences, 2021
Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with the development of certain cancers; however, no studies have specifically examined the role of PYCR1 in hepatocellular carcinoma (HCC). Based on The Cancer Genome Atlas expression array and meta-analysis conducted using the Gene Expression Omnibus database, we ...
Xu, Yanzhen, Zuo, Wenpu, Wang, Xiao, Zhang, Qinle, Gan, Xiang, Tan, Ning, Jia, Wenxian, Liu, Jiayi, Li, Zhouquan, Zhou, Bo, Zhao, Dong, Xie, Zhibin, Tan, Yanjun, Zheng, Shengfeng, Liu, Chengwu, Li, Hongtao, Chen, Zhijian, Yang, Xiaoli, Huang, Zhaoquan   +18 more
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