Proline metabolism and transport in plant development [PDF]
, 2018 Proline fulfils diverse functions in plants. As amino acid it is a structural component of proteins, but it also plays a role as compatible solute under environmental stress conditions.
Lehmann, Silke +3 more
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Understanding proline metabolism in hypoxic cancer cells [PDF]
, 2023 To survive, cancer cells adapt their metabolism to sustain increased biomass production and bioenergetic demand as well as modulation of redox homeostasis.
Vettore, Lisa
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MiRNA and Proline Metabolism in Cancer [PDF]
, 2013 Tumor metabolism and bioenergetics are important areas for cancer research and present promising targets for anticancer therapy. Growing tumors alter their metabolic profiles to meet the bioenergetic and biosynthetic demands of increased cell growth and proliferation.
Wei Liu, James M.
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Mechano-regulation of proline metabolism and cancer progression by kindlin-2
Molecular & Cellular Oncology, 2019 Alterations of cell mechano-environment and metabolism are common features of malignant neoplasm. We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano ...
Ling Guo, Chuanyue Wu
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PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
Nature Communications, 2020 Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in
Ling Guo +9 more
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Proline Metabolism and Its Functions in Development and Stress Tolerance
, 2019 Proline takes an exceptional place among the proteinogenic amino acids by its specific accumulation in pollen and in response to multiple types of stress.
Trovato, Maurizio +7 more
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Proline transport inhibitors trigger differential responses in Trypanosoma cruzi growth inhibition
, 2021 Background: Proline is a fundamental amino acid for Trypanosoma cruzi, the etiological agent of Chagas disease. Proline is mainly incorporated from the extracellular medium by amino acid transport systems.
Lucas , Pagura +5 more
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Rewiring of proline metabolism in colorectal carcinogenesis: causes and consequences
, 2022 Colorectal cancer (CRC) is the fourth most common cancer in the UK. Recently, the metabolism of non-essential amino acids in cancer has been identified as an area of interest for novel therapeutic targets.
Lynsey Burke (12055056)
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L-proline metabolism and the regulation of embryonic stem cell differentiation and programming
, 2019 \\(Objective:\\) Proline metabolism has been implied in cancer, with changes found to support the growth and metastasis of cancer cells. Based on this, proline metabolism has been proposed as a safe and specific target for cancer therapy.
Nguyen, VTT (15934076)
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Multiple roles of proline transport and metabolism in trypanosomatids
Frontiers in Bioscience, 2012 Trypanosomatids are a large family of unicellular eukaryotes, many of which are parasites in higher eukaryotes including man. Much of our understanding of metabolism in these organisms has been gained form the study of the human infective representatives (Trypanosoma brucei subpecies, Trypanosoma cruzi and Leishmania spp.) which are transmitted by ...
Frederic, Bringaud +2 more
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