Results 61 to 70 of about 1,773 (164)

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

EMBO Reports
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Cheng Chen, Qianyu Liu, Wenjie Chen, Zhiyuan Gong, Bo Kang, Meihua Sui, Liming Huang, Ying-Jie Wang   +7 more
doaj   +1 more source

Proline Metabolism of Different Varieties of Hami Melon Fruits in Response to Low Temperature [PDF]

Shipin Kexue
In order to investigate the change in proline metabolism of two varieties of Hami melon fruits during low-temperature storage, ‘Xizhoumi 25’ and ‘Gashi’ melons were pre-cooled for 24 h and then placed for up to 42 days in a mechanical cold storage at (3 ...
BI Ying, WANG Xinyu, LI Hui, HUANG Shuai, ZHANG Qi, LEI Yaxin, WANG Xue, WANG Fuxin, XU Wenchang, WANG Jing
doaj   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach

Insect Molecular Biology, Volume 34, Issue 5, Page 632-644, October 2025.
Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Jessica Cristina Silva Martins, Héctor Antônio Assunção Romão, Carolina Kurotusch Canettieri, Amanda Caetano Cercilian, Patrícia Rasteiro Ordiale Oliveira, Clelia Ferreira, Walter R. Terra, Renata de Oliveira Dias   +7 more
wiley   +1 more source

Screening and characterization of proline dehydrogenase flavoenzyme producing Pseudomonas entomophila

Iranian Journal of Microbiology, 2011
Background and Objectives: Proline dehydrogenase (ProDH; 1.5.99.8) plays an important role in specific determination of plasma proline level in biosensor and diagnostic kits.
H Shahbaz- Mohammadi, E Omidinia
doaj  

Proline Protects Boar Sperm against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine

Animals, 2020
Proline was reported to improve sperm quality in rams, stallions, cynomolgus monkeys, donkeys, and canines during cryopreservation. However, the underlying mechanism remains unclear.
Chengwen Feng, Zhendong Zhu, Wenjing Bai, Rongnan Li, Yi Zheng, Xiu’e Tian, De Wu, Hongzhao Lu, Yongjun Wang, Wenxian Zeng   +9 more
doaj   +1 more source

Disruption of the Prolidase–Proline–PRODH Axis and Oxidative Stress in Schizophrenia

Van Tıp Dergisi
INTRODUCTION: This study aimed to investigate serum levels of proline, prolidase, proline dehydrogenase (PRODH), and reactive oxygen species (ROS) in patients with schizophrenia and healthy controls, to evaluate potential differences between groups and ...
Mehmet Güneş, Burhan Çoban, Betül Uyar, Mehmet Cemal Kaya, Nuriye Mete, Mahmut Bulut   +5 more
doaj   +1 more source

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions

Frontiers in Plant Science, 2015
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Yanina Soledad Rizzi, Mariela Inés Monteoliva, Georgina eFabro, Carola Lucrecia Grosso, Laura Elena Laróvere, Maria Elena Alvarez   +5 more
doaj   +1 more source

Transcriptional Dynamics of Tomato Plants Under Combined Heat and Salt Stress

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT The Mediterranean Basin, a hotspot for tomato production, is one of the most vulnerable areas to climate change, where rising temperatures and increasing soil and water salinization represent major threats to agricultural sustainability. Thus, to understand the molecular mechanisms behind plant responses to this stress combination, an RNA‐Seq ...
Bruno Sousa, Cristiano Soares, Paulo Ricardo Oliveira‐Pinto, Conceição Santos, Fernanda Fidalgo, Teresa Lino‐Neto   +5 more
wiley   +1 more source