Results 61 to 70 of about 1,610 (139)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, Volume 20, Issue 2, Page 447-463, February 2026.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

EMBO Reports
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood.
Cheng Chen, Qianyu Liu, Wenjie Chen, Zhiyuan Gong, Bo Kang, Meihua Sui, Liming Huang, Ying-Jie Wang   +7 more
doaj   +1 more source

Drought-induced responses of organic osmolytes and proline metabolism during pre-flowering stage in leaves of peanut (Arachis hypogaea L.)

Journal of Integrative Agriculture, 2017
: Peanut (Arachis hypogaea L.), an improtant oil crop, usually encounters drought stress in the process of growth and development, especially at pre-flowering stage.
Ming ZHANG, Li-feng WANG, Kun ZHANG, Feng-zhen LIU, Yong-shan WAN   +4 more
doaj   +1 more source

Comparative Study of the Mitochondrial Proteome From Mesophyll, Vascular, and Guard Cells in Response to Carbon Starvation

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT A leaf is an organ composed of different tissues that fulfill specific functions. We hypothesized that since cells in vascular or mesophyll tissues as well as in stoma are developmentally tuned to operate their functions, mitochondria from these cells could exhibit significant metabolic differences.
Clément Boussardon, Shah Hussain, Olivier Keech   +2 more
wiley   +1 more source

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions

Frontiers in Plant Science, 2015
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Yanina Soledad Rizzi, Mariela Inés Monteoliva, Georgina eFabro, Carola Lucrecia Grosso, Laura Elena Laróvere, Maria Elena Alvarez   +5 more
doaj   +1 more source

Transcriptional Dynamics of Tomato Plants Under Combined Heat and Salt Stress

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT The Mediterranean Basin, a hotspot for tomato production, is one of the most vulnerable areas to climate change, where rising temperatures and increasing soil and water salinization represent major threats to agricultural sustainability. Thus, to understand the molecular mechanisms behind plant responses to this stress combination, an RNA‐Seq ...
Bruno Sousa, Cristiano Soares, Paulo Ricardo Oliveira‐Pinto, Conceição Santos, Fernanda Fidalgo, Teresa Lino‐Neto   +5 more
wiley   +1 more source

Evaluation of P5CS and ProDH activity in Paulownia tomentosa (Steud.) as an indicator of oxidative changes induced by drought stress [PDF]

PeerJ
The aim of the study was to investigate changes in proline metabolism in seedlings of tree species during drought stress. One month old Paulownia tomentosa seedlings were exposed to moisture conditions at various levels (irrigation at 100, 75, 50 and 25%
Joanna Kijowska-Oberc, Mikołaj K. Wawrzyniak, Liliana Ciszewska, Ewelina Ratajczak   +3 more
doaj   +2 more sources

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Dissecting the Phenotypic Spectrum and Complexity of Movement Disorders in 22q11.2 Deletion Syndrome

European Journal of Neurology, Volume 32, Issue 6, June 2025.
In this study, we deeply phenotyped 31 unrelated adults with molecular confirmation of 22q11.2 microdeletion who were referred for neurologic assessments at a major centre of excellence in movement disorders. At the group level, majority (77%) presented with two or more movement disorder phenotypes, with similar trends in prevalence after accounting ...
Nikolai Gil D. Reyes, Talyta Grippe, Marcus Callister, Tarig Abkur, Emilio Q. Villanueva III, Tracy Heung, Robert Chen, Erik Boot, Anne S. Bassett, Anthony E. Lang   +9 more
wiley   +1 more source

Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis

BMC Plant Biology, 2010
Background Proline (Pro) accumulation is a widespread response of prokaryotic and eukaryotic cells subjected to osmotic stress or dehydration. When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and ...
Müller Gudrun, Eckard Sonja, Funck Dietmar   +2 more
doaj   +1 more source