Results 71 to 80 of about 1,773 (164)

Study of regulatory factors in Non Small Cell Lung Cancer: a role for Proline Dehydrogenase? [PDF]

, 2021
Proline dehydrogenase (PRODH) is a mitochondrial inner-membrane and stressinducible flavoenzyme catalysing the first step in the proline degradation pathway. Due to its distinctive chemical structure, in fact, proline is metabolized by a distinct set
GROSSI SARAH
core  

Evaluation of P5CS and ProDH activity in Paulownia tomentosa (Steud.) as an indicator of oxidative changes induced by drought stress [PDF]

PeerJ
The aim of the study was to investigate changes in proline metabolism in seedlings of tree species during drought stress. One month old Paulownia tomentosa seedlings were exposed to moisture conditions at various levels (irrigation at 100, 75, 50 and 25%
Joanna Kijowska-Oberc, Mikołaj K. Wawrzyniak, Liliana Ciszewska, Ewelina Ratajczak   +3 more
doaj   +2 more sources

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Proline metabolism.

, 2013
Abbreviations: PRO, proline; PRODH, proline oxidase (a.k.a. proline dehydrogenase); P5CR, pyrroline-5-carboxylate reductase; P5C, pyrroline-5-carboxylate; GSA, glutamic semialdehyde; P5CDH, pyrroline-5-carboxylate dehydrogenase; P5CS, pyrroline-5 ...
Brian Suárez Mantilla (435600), Maria Carolina Elias (243026), Lisvane Silva Paes (267021), Patrícia Diogo de Melo (435603), Erich B. Tahara (284264), Ariel Mariano Silber (167356), Elisabeth Mieko Furusho Pral (435602), Alicia J. Kowaltowski (284269), Flávia Menezes Zimbres (435601)   +8 more
core   +1 more source

High yields of active Thermus thermophilus proline dehydrogenase are obtained using maltose-binding protein as a solubility tag.

, 2015
Proline dehydrogenase (ProDH) catalyzes the FAD-dependent oxidation of proline to ¿1-pyrroline-5-carboxylate, the first step of proline catabolism in many organisms.
Huijbers, M.M.E., van Berkel, W.J.H., Berkel, W.J.H., van   +2 more
core   +1 more source

Dissecting the Phenotypic Spectrum and Complexity of Movement Disorders in 22q11.2 Deletion Syndrome

European Journal of Neurology, Volume 32, Issue 6, June 2025.
In this study, we deeply phenotyped 31 unrelated adults with molecular confirmation of 22q11.2 microdeletion who were referred for neurologic assessments at a major centre of excellence in movement disorders. At the group level, majority (77%) presented with two or more movement disorder phenotypes, with similar trends in prevalence after accounting ...
Nikolai Gil D. Reyes, Talyta Grippe, Marcus Callister, Tarig Abkur, Emilio Q. Villanueva III, Tracy Heung, Robert Chen, Erik Boot, Anne S. Bassett, Anthony E. Lang   +9 more
wiley   +1 more source

Characterisation of proline dehydrogenase and its contribution to energy metabolism in Trypanosoma brucei [PDF]

, 2004
Both Leishmania major and Trypanosoma brucei undergo a complicated developmental cycle involving insect vectors and a mammalian host, subjecting these parasites to dramatic changes in their environment.
Lamour, Nadia
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Molecular and Biochemical Characterization of the proline dehydrogenase of T. cruzi, a possible therapeutical target .

, 2010
Os nossos resultados demonstraram a atividade enzimática prolina desidrogenase (PRODH) do produto do gene anotado como codificante de uma prolina oxidase na base dados do genoma de Trypanosoma cruzi.
Lisvane Paes Vieira, Vieira, Lisvane Paes   +1 more
core   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, Volume 292, Issue 12, Page 2973-2991, June 2025.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Multi‐Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide‐Induced Mouse Model of Depression

Brain and Behavior, Volume 15, Issue 5, May 2025.
The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li, Rui Xiao, Xue‐Yi Chen, Jun‐Cai Pu, Jian‐Jun Chen, Hai‐Yang Wang, Lan‐Xiang Liu, Dan Li, Yang‐Dong Zhang, Wen‐Xia Li, Peng Xie   +10 more
wiley   +1 more source