Results 91 to 100 of about 1,778 (165)

Multi‐Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide‐Induced Mouse Model of Depression

Brain and Behavior, Volume 15, Issue 5, May 2025.
The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li, Rui Xiao, Xue‐Yi Chen, Jun‐Cai Pu, Jian‐Jun Chen, Hai‐Yang Wang, Lan‐Xiang Liu, Dan Li, Yang‐Dong Zhang, Wen‐Xia Li, Peng Xie   +10 more
wiley   +1 more source

Proline Dehydrogenase as new marker and target in EGFR mutant Non-Small Cell Lung carcinoma [PDF]

, 2022
Non-Small Cell Lung Cancer (NSCLC) is one of the most frequent types of tumor for incidence and the leading cause of cancer mortality. Identification of markers to better define diagnosis, prognosis and therapeutic options of NSCLC is needed.
Raffaella Cinquetti, Carminia Maria Della Corte, Vincenza Ciaramella, Floriana Morgillo, Paola Campomenosi, Antonino Bruno, Priscilla Chiofalo, Elena Berno, Anna Maria Chiaravalli, Sarah Grossi   +9 more
core  

Molecular evolution and transcriptional regulation of the oilseed rape proline dehydrogenase genes suggest distinct roles of proline catabolism during development [PDF]

, 2015
International audienceSix BnaProDH1 and two BnaProDH2 genes were identified in Brassica napus genome. The BnaProDH1 genes are mainly expressed in pollen and roots' organs while BnaProDH2 gene expression is associated with leaf vascular tissues at ...
Niogret, Marie-Françoise, Leport, Laurent, Clouet, Vanessa, Orsel, Mathilde, M., Faës, Pascal, Montes, Emilie, Albert, Benjamin, Bouchereau, Alain, Lassalle, Gilles, Gouraud, Anne-Marie, Aïnouche, Abdelkader, Le Cahérec, Françoise, Orsel, Mathilde,, Deleu, Carole   +13 more
core   +1 more source

Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia [PDF]

, 2003
People with deletion of the chromosome 22q11 region associated with velo cardio-facial syndrome (VCFS) have a remarkably high risk of developing schizophrenia.
N. Williams, N. Norton, H.J. Williams, Norton, N., Williams, Nigel Melville, Spurlock, G., M.J. Owen, M.C. O'Donovan, Kirov, George, Williams, H.J., Zammit, Stanley, G. Spurlock, O'Donovan, Michael Conlon, S. Zammit, G. Kirov, Owen, Michael John   +15 more
core   +1 more source

Morpho-biochemical plasticity and efficient crosstalk in proline metabolism governs stress resilience in indica rice

Environmental and Experimental Botany
Plants face recurrent challenges from various abiotic stresses, including salt and drought. Being sessile, they employ adaptive strategies through root architectural modifications, enhanced antioxidant activity, accumulation of osmoprotectants like ...
Shivani Shivani, Soumyayan Roy, Arpita Das, Joydeep Banerjee   +3 more
doaj   +1 more source

Melatonin Combined with 1-Methylcyclopropene Regulates Proline Metabolism to Alleviate Chilling Injury in Postharvest Hami Melons [PDF]

Shipin Kexue
To investigate the effects of melatonin (MT) in combination with 1-methylcyclopropene (1-MCP) on postharvest proline metabolism and chilling injury in Hami melons, this study included four treatments: control (distilled water immersion + distilled water ...
WANG Xiaobing, JIA Meihui, GAO Zhongchuan, CHEN Haixin, CHEN Xiaojie, ZHANG Zonghao, WENG Wanlin, WANG Yu, WANG Jing
doaj   +1 more source

Exogenous proline enhances salt acclimation in soybean seedlings: Modifying physicochemical properties and controlling proline metabolism through the ornithine-glutamate dual pathway

Ecotoxicology and Environmental Safety
Soil salinization has emerged as a major factor negatively affecting soil quality and plant productivity. Proline, functioning as an osmotic regulator, has been proposed as an effective strategy for enhancing plant tolerance to salt stress.
Lei Yan, Mu Lu, Muhammad Riaz, Kaiqing Tong, Hualong Yu, Guang Gao, Yusheng Niu   +6 more
doaj   +1 more source

Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells

Frontiers in Microbiology, 2018
Under physiological conditions, most human endogenous retroviruses (HERVs) are transcriptionally silent. However, re-activation of HERVs is observed under pathological conditions like inflammation or cancer.
Thomas Mueller, Claudia Hantsch, Ines Volkmer, Martin S. Staege   +3 more
doaj   +1 more source

l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells

Toxins, 2019
The toxicity and related mechanisms of aflatoxin B1 (AFB1) and aflatoxin M1 (AFM1) in the mouse kidney were studied, and the role of l-proline in alleviating kidney damage was investigated.
Huiying Li, Songli Li, Huaigu Yang, Yizhen Wang, Jiaqi Wang, Nan Zheng   +5 more
doaj   +1 more source

Unravelling the role of proline dehydrogenase (PRODH) in lung adenocarcinoma: implications for cellular senescence and the tumor microenvironment [PDF]

Proline dehydrogenase (PRODH) is a mitochondrial flavoenzyme that catalyzes proline oxidation. The electrons generated from this reaction can be used to produce ATP or ROS, potentially affecting several cellular processes, such as survival, apoptosis ...
Raffaella Cinquetti, Paola Campomenosi, Antonino Bruno, Elena Berno, Priscilla Chiofalo, Maria Teresa Palano   +5 more
core