Results 81 to 90 of about 1,773 (164)

Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aims Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a poorly understood etiology. Recent studies have suggested that metabolic dysregulation might be linked to the development of ASD; however, causal relationships remain unclear.
Wenhua Li, Suya Ma, Yunong Tian
wiley   +1 more source

Proline dehydrogenase is essential for proline protection against hydrogen peroxide induced cell death

, 2012
Proline metabolism has an underlying role in apoptotic signaling that impacts tumorigenesis. Proline is oxidized to glutamate in the mitochondria with the rate limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53
Zhu, Weidong, Simpson, Melanie A., Zhang, Lu, Becker, Donald F., Demers, Andrew, Liang, Xinwen, Natarajan, Sathish Kumar, Zimmerman, Matthew C.   +7 more
core  

Proline Dehydrogenase affects lung cancer cell proliferation by inducing ROS and cellular senescence

, 2023
Proline dehydrogenase (PRODH) is a mitochondrial flavoenzyme that catalyzes proline oxidation. Its catabolism is linked to basic cellular metabolism.
Raffaella Cinquetti, Eleonora Zini, Matteo Gallazzi, Paola Campomenosi, Antonino Bruno, Elena Berno, Priscilla Chiofalo, Maddalena Zana   +7 more
core   +1 more source

Morpho-biochemical plasticity and efficient crosstalk in proline metabolism governs stress resilience in indica rice

Environmental and Experimental Botany
Plants face recurrent challenges from various abiotic stresses, including salt and drought. Being sessile, they employ adaptive strategies through root architectural modifications, enhanced antioxidant activity, accumulation of osmoprotectants like ...
Shivani Shivani, Soumyayan Roy, Arpita Das, Joydeep Banerjee   +3 more
doaj   +1 more source

Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells

Frontiers in Microbiology, 2018
Under physiological conditions, most human endogenous retroviruses (HERVs) are transcriptionally silent. However, re-activation of HERVs is observed under pathological conditions like inflammation or cancer.
Thomas Mueller, Claudia Hantsch, Ines Volkmer, Martin S. Staege   +3 more
doaj   +1 more source

Proline and GABA biosynthesis pathway.

, 2018
For the figure legend refers to Fig 2. Abbreviations: GSA: glutamate-semialdehyde. P5C: L-1-Pyrroline-5-carboxylate. GABA: 4-aminobutanoate. P5CR: P5C reductase. P5CS1: glutamate-5-kinase. P5CS2: GSA dehydrogenase.
Lenny de Jaeger (5100551), Benoit M. Carreres (5100545), Vitor A. P. Martins Dos Santos (5100554), Gerrit Eggink (2084200), Rene H. Wijffels (5100548), Dirk E. Martens (3922190), Peter J. Schaap (216954), Jan Springer (91078)   +7 more
core   +1 more source

Exogenous proline enhances salt acclimation in soybean seedlings: Modifying physicochemical properties and controlling proline metabolism through the ornithine-glutamate dual pathway

Ecotoxicology and Environmental Safety
Soil salinization has emerged as a major factor negatively affecting soil quality and plant productivity. Proline, functioning as an osmotic regulator, has been proposed as an effective strategy for enhancing plant tolerance to salt stress.
Lei Yan, Mu Lu, Muhammad Riaz, Kaiqing Tong, Hualong Yu, Guang Gao, Yusheng Niu   +6 more
doaj   +1 more source

l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells

Toxins, 2019
The toxicity and related mechanisms of aflatoxin B1 (AFB1) and aflatoxin M1 (AFM1) in the mouse kidney were studied, and the role of l-proline in alleviating kidney damage was investigated.
Huiying Li, Songli Li, Huaigu Yang, Yizhen Wang, Jiaqi Wang, Nan Zheng   +5 more
doaj   +1 more source

Proline dehydrogenase activity of mungbean rhizobia and their proline prototrophs in relation to their efficacy in symbiotic association

, 1999
1234-1240Proline dehydrogeanase (ProDH) is a key enzyme which catabolises proline to yield additional energy to support N2 fixation in legume root nodules. Tn5 mutagenesis of four mungbean infeccting Rhizobium  strains Mo-2 ,Mo-6 PP9038 (PH9022) and G-
Khurana, A L, Dudeja, S S, Sharma, H R, Malik, M S, Chaudhary, S   +4 more
core  

Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein

, 2003
The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilization genes.
Shorena Nadaraia, John J. Tanner, Lee, Yong Hwan, Gu, Dan, Nadaraia, Shorena, Becker, Donald F., Yong-Hwan Lee, Donald F. Becker, Dan Gu, Tanner, John J.   +9 more
core   +1 more source