Results 81 to 90 of about 1,778 (165)

Disruption of the Prolidase–Proline–PRODH Axis and Oxidative Stress in Schizophrenia

Van Tıp Dergisi
INTRODUCTION: This study aimed to investigate serum levels of proline, prolidase, proline dehydrogenase (PRODH), and reactive oxygen species (ROS) in patients with schizophrenia and healthy controls, to evaluate potential differences between groups and ...
Mehmet Güneş, Burhan Çoban, Betül Uyar, Mehmet Cemal Kaya, Nuriye Mete, Mahmut Bulut   +5 more
doaj   +1 more source

P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions

Frontiers in Plant Science, 2015
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ1 pyrroline-5-
Yanina Soledad Rizzi, Mariela Inés Monteoliva, Georgina eFabro, Carola Lucrecia Grosso, Laura Elena Laróvere, Maria Elena Alvarez   +5 more
doaj   +1 more source

Study of regulatory factors in Non Small Cell Lung Cancer: a role for Proline Dehydrogenase? [PDF]

, 2021
Proline dehydrogenase (PRODH) is a mitochondrial inner-membrane and stressinducible flavoenzyme catalysing the first step in the proline degradation pathway. Due to its distinctive chemical structure, in fact, proline is metabolized by a distinct set
GROSSI SARAH
core  

Evaluation of P5CS and ProDH activity in Paulownia tomentosa (Steud.) as an indicator of oxidative changes induced by drought stress [PDF]

PeerJ
The aim of the study was to investigate changes in proline metabolism in seedlings of tree species during drought stress. One month old Paulownia tomentosa seedlings were exposed to moisture conditions at various levels (irrigation at 100, 75, 50 and 25%
Joanna Kijowska-Oberc, Mikołaj K. Wawrzyniak, Liliana Ciszewska, Ewelina Ratajczak   +3 more
doaj   +2 more sources

Transcriptional Dynamics of Tomato Plants Under Combined Heat and Salt Stress

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT The Mediterranean Basin, a hotspot for tomato production, is one of the most vulnerable areas to climate change, where rising temperatures and increasing soil and water salinization represent major threats to agricultural sustainability. Thus, to understand the molecular mechanisms behind plant responses to this stress combination, an RNA‐Seq ...
Bruno Sousa, Cristiano Soares, Paulo Ricardo Oliveira‐Pinto, Conceição Santos, Fernanda Fidalgo, Teresa Lino‐Neto   +5 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Characterisation of proline dehydrogenase and its contribution to energy metabolism in Trypanosoma brucei [PDF]

, 2004
Both Leishmania major and Trypanosoma brucei undergo a complicated developmental cycle involving insect vectors and a mammalian host, subjecting these parasites to dramatic changes in their environment.
Lamour, Nadia
core  

Dissecting the Phenotypic Spectrum and Complexity of Movement Disorders in 22q11.2 Deletion Syndrome

European Journal of Neurology, Volume 32, Issue 6, June 2025.
In this study, we deeply phenotyped 31 unrelated adults with molecular confirmation of 22q11.2 microdeletion who were referred for neurologic assessments at a major centre of excellence in movement disorders. At the group level, majority (77%) presented with two or more movement disorder phenotypes, with similar trends in prevalence after accounting ...
Nikolai Gil D. Reyes, Talyta Grippe, Marcus Callister, Tarig Abkur, Emilio Q. Villanueva III, Tracy Heung, Robert Chen, Erik Boot, Anne S. Bassett, Anthony E. Lang   +9 more
wiley   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, Volume 292, Issue 12, Page 2973-2991, June 2025.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

PRODH rs450046 and proline x COMT Val(158)Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome [PDF]

, 2015
22q11 deletion syndrome (22q11DS) is associated with an increased risk for psychotic disorders, suggesting a relationship between genotypes and the pathophysiology of psychotic disorders.
Bloemen, Oswald J. N., van Amelsvoort, Therese A. M. J., van Duin, Esther D. A., de Koning, Mariken B., Bakker, Jaap A., Abel, Kathryn M., Boot, Erik   +6 more
core   +1 more source