Results 101 to 110 of about 2,628 (173)

Differentiation-Dependent Regulation of Human Endogenous Retrovirus K Sequences and Neighboring Genes in Germ Cell Tumor Cells

Frontiers in Microbiology, 2018
Under physiological conditions, most human endogenous retroviruses (HERVs) are transcriptionally silent. However, re-activation of HERVs is observed under pathological conditions like inflammation or cancer.
Thomas Mueller, Claudia Hantsch, Ines Volkmer, Martin S. Staege   +3 more
doaj   +1 more source

Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages [PDF]

, 2014
Macrophages play a major role in the immune system, both as antimicrobial effector cells and as immunoregulatory cells, which induce, suppress or modulate adaptive immune responses.
Abebe, Albina, Albina, Asano, Barilli, Bauer, Baydoun, Baydoun, Biswas, Boger, Bredt, Bussiere, Chang, Cloke, Closs, Closs, Closs, Colegio, Corraliza, Duque-Correa, El Kasmi, El-Gayar, Erdely, Feldmeyer, Fotiadis, Furchgott, Gabrilovich, Ganeshan, Geller, Ghesquiere, Gordon, Hatzoglou, Hecker, Heitmann, Herbert, Hesse, Hey, Hibbs, Hibbs, Ignarro, Ignarro, Jenkinson, Kaneko, Kapp, Kawahara, Kitowska, Kropf, Kropf, Lamour, Lee, Lewis, Lyons, Maarsingh, MacMicking, Marletta, Mattila, Michel, Mieulet, Mills, Mills, Mills, Modolell, Modolell, Mori, Morris, Mossner, Muller, Munder, Munder, Munder, Munder, Munder, Munder, Munder, Murray, Murray, Murray, Narita, Nicholson, Niese, Noy, Nussler, Osorio, Palmer, Palmer, Pauleau, Pegg, Perner, Pesce, Qualls, Qualls, Raber, Raes, Rauh, Rodriguez, Rothenberg, Rotoli, Rotoli, Rotondo, Sahin, Sans-Fons, Serrat, Sheldon, Shirey, Sica, Southan, Stuehr, Stuehr, Stuehr, Szabo, Tabor, Takele, Tao, Taylor, Vats, Windmueller, Wu, Xie, Yeramian, Zhang, Zimmermann   +120 more
core   +2 more sources

l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells

Toxins, 2019
The toxicity and related mechanisms of aflatoxin B1 (AFB1) and aflatoxin M1 (AFM1) in the mouse kidney were studied, and the role of l-proline in alleviating kidney damage was investigated.
Huiying Li, Songli Li, Huaigu Yang, Yizhen Wang, Jiaqi Wang, Nan Zheng   +5 more
doaj   +1 more source

Exogenous proline enhances salt acclimation in soybean seedlings: Modifying physicochemical properties and controlling proline metabolism through the ornithine-glutamate dual pathway

Ecotoxicology and Environmental Safety
Soil salinization has emerged as a major factor negatively affecting soil quality and plant productivity. Proline, functioning as an osmotic regulator, has been proposed as an effective strategy for enhancing plant tolerance to salt stress.
Lei Yan, Mu Lu, Muhammad Riaz, Kaiqing Tong, Hualong Yu, Guang Gao, Yusheng Niu   +6 more
doaj   +1 more source

Biotechnological approaches to study plant responses to stress [PDF]

, 2013
Multiple biotic and abiotic environmental stress factors affect negatively various aspects of plant growth, development, and crop productivity. Plants, as sessile organisms, have developed, in the course of their evolution, efficient strategies of ...
Gomez-Cadenas, Aurelio, I Zandalinas, Sara, López Climent, María Fernanda, Muñoz Espinoza, Valeria Alejandra, Pérez Clemente, Rosa María, Vives, Vicente   +5 more
core   +4 more sources

Investigation of Proline Utilization A: Kinetic Analysis of Substrate Channel-blocking Mutants and Creation of a Trifunctional Chimera Enzyme [PDF]

, 2013
Proline metabolism is known to be involved in many cellular processes such as cell signaling, cellular redox balance, and cell survival. One of the enzymes involved in proline catabolism, proline utilization A, plays a role in oxidizing proline to ...
Arentson, Benjamin W
core   +1 more source

Evidence for Hysteretic Substrate Channeling in the Proline Dehydrogenaseand ∆\u3csup\u3e1\u3c/sup\u3e-Pyrroline-5-carboxylate Dehydrogenase Coupled Reaction of Proline UtilizationA(PutA) [PDF]

, 2014
Background: PutA from Escherichia coli is a bifunctional enzyme and transcriptional repressor in proline catabolism. Results: Steady-state and transient kinetic data revealed a mechanism in which the two enzymatic reactions are coupled by an activation ...
Becker, Donald F., Krishnan, Navasona, Moxley, Michael A, Sanyal, Nikhilesh, Tanner, John J.   +4 more
core   +1 more source

Structural and kinetic studies of bifunctional and monofunctional proline catabolic enzymes [PDF]

Title from PDF of title page (University of Missouri--Columbia, viewed on December 4, 2015).PutAs, Proline dehydrogenase and P5C dehydrogenase are involved in the oxidation of proline to glutamate. Mutations in proline dehydrogenase and P5C dehydrogenase
Srivastava, Dhiraj
core   +1 more source

Ascorbic Acid Improves Tomato Salt Tolerance by Regulating Ion Homeostasis and Proline Synthesis

Plants
In this study, processing tomato (Solanum lycopersicum L.) ‘Ligeer 87-5’ was hydroponically cultivated under 100 mM NaCl to simulate salt stress. To investigate the impacts on ion homeostasis, osmotic regulation, and redox status in tomato seedlings ...
Xianjun Chen, Hongwei Han, Yundan Cong, Xuezhen Li, Wenbo Zhang, Jinxia Cui, Wei Xu, Shengqun Pang, Huiying Liu   +8 more
doaj   +1 more source

Root-Specific Overexpression of the CmDUF239-1 Gene Enhances Heat Tolerance in Melon Seedlings by Upregulating Antioxidant Enzymes Activities, Proline Content, and Expression of Heat Shock Protein-Related Genes

Horticulturae
High temperature stress is a critical factor affecting the growth and yield of melons (Cucumis melo L.), and improving heat tolerance is therefore crucial for stable production.
Yang Li, Zhanming Tan, Yanjun Liu, Yuquan Peng, Chunyan Liu   +4 more
doaj   +1 more source